5) Division of Hematology, Spedali Civili Hospital and University, Brescia, Italy: Chiara Bottelli, Alessandra Tucci, Giuseppe Rossi

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1 INSTITUTIONS WHO PARTICIPATED TO THE STUDY 1) Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy: Chiara Lobetti Bodoni, Barbara Mantoan, Elisa Genuardi, Mario Boccadoro, Marco Ladetto 2) Unit of Cancer Epidemiology, Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy: Giovannino Ciccone, Andrea Evangelista, Manuela Ceccarelli 3) Division of Hematology 2, Azienda Ospedaliera Città della Salute e della Scienza, Turin, Italy: Carola Boccomini, Annalisa Chiappella, Barbara Botto, Lorella Orsucci, Umberto Vitolo 4) Division of Hematology, Fondazione IRCCS Cà Granda OM Policlinico, University of Milan, Milan Italy: Maria Goldaniga, Francesca Gaia Rossi, Luca Baldini 5) Division of Hematology, Spedali Civili Hospital and University, Brescia, Italy: Chiara Bottelli, Alessandra Tucci, Giuseppe Rossi 6) Division of Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy: Alessandro Pulsoni, Federico De Angelis, Eleonora Russo, Maurizio Martelli, Robin Foà 7) Division of Hematology, Oncology, and Clinical Pathology; Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy: Francesco Di Raimondo, Annalisa Chiarenza 8) Hematology Functional Unit, Azienda Ospedaliera Universitaria Careggi, Firenze, Italy: Luigi Rigacci, Benedetta Puccini, Alberto Bosi 9) Istituto Nazionale Tumori, Fondazione G. Pascale, Istituto Di Ricovero e Cura a Carattere Scientifico IRCCS, Naples, Italy. Antonello Pinto 10) Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy: Mario Petrini, Sara Galimberti 11) Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.: Alessia Bari, Stefano Sacchi, Massimo Federico 12) Universitary Division of Medical Oncology, Fondazione del Piemonte per l Oncologia Istituto per la Ricerca e la Cura del Cancro, Candiolo, Turin, Italy. Delia Rota Scalabrini, Massimo Aglietta 13) Hematology Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy: Angela Ferrari,Isabel Alvarez De Celis, Francesco Merli 14) Division of Hematology and Bone Marrow Transplantation, Azienda Ospedaliero Universitaria Udine, Udine, Italy: Francesco Zaja, Renato Fanin 15) Hematology Department and BMT Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy: Claudia Castellino, Andrea Gallamini 16) Internal Medicine Hematology, S. Luigi Hospital, University of Turin, Orbassano, Italy: Guido Parvis, Giuseppe Saglio 17) Division of Hematology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy: Tommasina Perrone, Giorgina Specchia 18) Division of Hematology, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy: Pellegrino Musto 19) Roche, S.p.A., Monza, Italy: Enrica Gamba

2 20) Hematology and BMT Unit, IRCCS National Institut of Tumor, Milano, Italy: Paolo Corradini 21) Division of Hematology, Department of Clinical and Preventive Medicine, University of Milano Bicocca, Monza, Italy: Enrico Maria Pogliani 22) Internal Medicin Department, Policlinico Monteluce and University, Perugia, Italy: Anna Marina Liberati 23) Hematology Unit, Policlinico Agostino Gemelli and Cattolica University, Roma, Italy: Giuseppe Leone 24) Hematology and BMT Unit, Vincenzo Cervello Hospital, Palermo, Italy: Caterina Patti 25) Hematology Unit, Spirito Santo Hospital and University, Pescara, Italy: Giuseppe Fioritoni 26) Hematology Unit, Niguarda Ca' Granda Hospital: Chiara Rusconi, Enrica Morra 27) Internal Medicine, Ospedale degli Infermi Hospital, Biella, Italy: Anna Tonso 28) Division of Hematology, Businco Hospital, Cagliari, Italy: Giuseppina Cabras, Emanuele Angelucci 29) Hematology Unit, Ospedali Riuniti Hospital and University, Bergamo, Italy: Andrea Rossi, Alessandro Rambaldi 30) Hematology and BMT Unit, San Maurizio Hospital, Bolzano, Italy: Sergio Cortelazzo 31) Division of Hematology, Hospital, Cremona, Italy: Sergio Morandi, Francesco Lanza 32) Hematology and BMT Unit, Policlinico G.B. Rossi and University, Verona, Italy: Giovanni Pizzolo 33) Division of Hematology, S. Eugenio Hospital and Tor Vergata University, Roma, Italy: Sergio Amadori 34) Hematology Unit, Policlinico Sant Orsola e Malpighi and University of Bologna, Bologna,Italy: Pier Luigi Zinzani 35) Hematology Unit, Bianchi Melacrino Morelli Hospital, Reggio Calabria, Italy: Caterina Stelitano, Francesco Nobile

3 LEGEND TO SUPPLEMENTAL FIGURES (ON LINE ONLY) Figure 1S. PFS by triple negativity at M8 M12 M18 by N PCR Figure 2S. PFS by PCR negativity by combined use of N PCR and RQ PCR at M8

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