ATENEO: Inhibition of quorum sensing and biofilm in Pseudomonas aeruginosa (Inibizione del quorum sensing e del biofilm in Pseudomonas aeruginosa)

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1 Specifiche economiche deliberate per il dottorato Ateneo Dip. Esterne Giovani Riserva Tassa Sovran ATENEO: Iron metabolism in pathogenic Gram-negative bacteria as a target for novel antimicrobials (Studio del metabolismo del ferro in batteri patogeni Gram-negativi per lo sviluppo di nuovi farmaci antibatterici) ESTERNE: Well-defined glycoconjugate via chemo-enzymatic synthesis of oligosaccharides for structure-based selection of vaccine candidates (Glicoconiugati ottenuti attraverso sintesi chemoenzimatica di oligosaccaridi per una selezione, basata sulla struttura, di candidati vaccinali). Dottorato in convenzione con Novartis Vaccines & Diagnostics (Siena, IT) ESTERNE: Use of genomics to investigate the virulence of diarrheagenic Escherichia coli, including their interactions with the human and animal intestinal microbiota (Uso della genomica nello studio della virulenza di ceppi di Escherichia coli diarreogeni ed interazioni di questi col microbiota umano ed animale). Dottorato in convenzione con l'istituto Superiore di Sanità (Roma) ESTERNE: Dissecting IL-33/ST2-dependent pathways in antitumor immune response to melanoma (Analisi di processi dipendenti da IL33/ST2 nella risposta antitumorale al melanoma). Dottorato in convenzione con l'istituto Superiore di Sanità (Roma) ATENEO: Inhibition of quorum sensing and biofilm in Pseudomonas aeruginosa (Inibizione del quorum sensing e del biofilm in Pseudomonas aeruginosa) ATENEO: Lipid metabolism in Rett syndrome (Metabolismo lipidico nella sindrome di Rett) ATENEO: Investigating breast cancer: role of estrogen receptor alpha intracellular trafficking (Studio del cancro al seno: ruolo del traffic intracellulare del recettore alfa per gli estrogeni) ATENEO: Estrogen/neuroglobin pathway in neurodegenerative disorders (Ruolo delle vie di segnale estrogeni/neuroglobina nelle patologie neurodegenerative) ATENEO: Interference with cell signalling pathways for the development of new therapies (Interferenza con le vie di segnalazione cellulare per lo sviluppo di nuove terapie). GIOVANI: Human health: biorecognition in health and disease (Salute dell uomo: aspetti funzionali e patologici del riconoscimento fra biomolecole) ESTERNE: Metagenomic and next generation sequencing approach to investigate zoonotic infectious agents (Metagenomica e sequenziamento di nuova generazione per indagare agenti zoonotici). Dottorato in convenzione con l'istituto Superiore di Sanità (Roma) SOVRANNUMERO: Identification of novel adhesins in pathogenic E. coli strains as a strategy for preventing intestinal colonization, supported by Marie Curie Initial Training Networks (ITN, Call:

2 FP7-PEOPLE-2012-ITN) project entitled "A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. coli infections - DISCo, Proposal Number , in collaboration with Novartis Vaccines & Diagnostics (Siena, IT) and INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA, Clermont FR). SOVRANNUMERO: Immunological characterization of novel adjuvants for generation of vaccines against pathogenic E. coli strains, supported by Marie Curie Initial Training Networks (ITN, Call: FP7-PEOPLE-2012-ITN) project entitled "A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. coli infections - DISCo, Proposal Number , in collaboration with Novartis Vaccines & Diagnostics (Siena, IT) and INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA, Clermont FR). SOVRANNUMERO: Not defined- Reserved to candidate selected by the IRAQ Government within a framework agreement with the Roma Tre University. Candidates applying for this position must consider the consistency of their programme with the main research areas of the PhD Programme in Biomedical Sciences and Technologies. SOVRANNUMERO: Not defined- Reserved to candidate selected by the IRAQ Government within a framework agreement with the Roma Tre University. Candidates applying for this position must consider the consistency of their programme with the main research areas of the PhD Programme in Biomedical Sciences and Technologies. SOVRANNUMERO: Not defined- Reserved to candidate selected by the IRAQ Government within a framework agreement with the Roma Tre University. Candidates applying for this position must consider the consistency of their programme with the main research areas of the PhD Programme in Biomedical Sciences and Technologies. Prove concorsuali Le prove saranno svolte secondo l'ordine indicato: 1) Valutazione titoli La valutazione dei titoli riguarda il percorso formativo universitario, nonché gli eventuali ulteriori percorsi formativi ed esperienze professionali e di ricerca e le eventuali pubblicazioni scientifiche. La valutazione è in trentesimi. 2) Prova scritta La prova scritta ha lo scopo di accertare l'attitudine dei candidati alla ricerca nelle Scienze e Tecnologie Biomediche, assicurando un'idonea valutazione comparativa: la prova intende valutare la conoscenza delle basi molecolari e cellulari di processi fisiologici e patologici, con particolare riferimento alle interazioni ospiteparassita, ai fenomeni che favoriscono l instaurarsi di condizioni patologiche, alle basi biochimiche e molecolari delle patologie, agli aspetti farmacologici correlati, agli adattamenti molecolari e cellulari correlati a processifisiologici e patologici. La valutazione è in trentesimi.

3 3) Prova orale La prova orale ha come oggetto un colloquio relativo ad aspetti di cultura scientifica, sia generale che specialistica, su problematiche attineti la salute umana e le Scienze e Tecnologie Biomediche, con riferimento anche alla pregressa esperienza del candidato nelle discipline caratterizzanti il corso di Dottorato. Verrà inoltre valutata la capacità di progettare una ricerca originale nei campi di ricerca caratterizzanti il corso di dottorato in Scienze e Tecnologie Biomediche, analizzando gli aspetti progettuali e metodologici e descrivendo letecniche più avanzate tipiche della ricerca biomedica di base ed applicata. A tal fine il candidato è tenuto a presentare e discutere il progetto di ricerca nella forma di una presentazione su schermo (proiezione PowerPoint) utilizzando un massimo di 10 diapositive in un tempo non superiore a 15 minuti. La prova orale sarà accompagnata ad una verifica della conoscenza dell inglese scientifico scritto e parlato. La verifica della conoscenza della lingua straniera si svolge a partire dalla lettura di un testo scientifico in inglese su argomenti attinenti le Scienze e Tecnologie Biomediche. Il candidato dovrà dimostrare la conoscenza della terminologia specifica del settore. La valutazione è in trentesimi. Ulteriori informazioni: Informazioni e recapiti: dottorato.scienze@uniroma3.it Curriculum Studiorum del Candidato Voce data e voto di laurea elenco degli esami sostenuti e relative votazioni Modalità OBBLIGATORIO OBBLIGATORIO elenco cronologico di Borse di studio, Assegni di ricerca (et similia) percepiti Diplomi/certificati di conoscenza lingue estere Diplomi/attestati di partecipazione di corsi universitari post-lauream Attestati di partecipazione a gruppi di ricerca Attestati di partecipazione a stage

4 Altri riconoscimenti (p. es.: premiazione in concorsi) Documentazione richiesta prima lettera di presentazione (a cura di un docente) seconda lettera di presentazione (a cura di un docente) descrizione delle precedenti esperienze di ricerca elenco delle pubblicazioni lettera di motivazione (a cura del candidato) indicazione di preferenza rispetto a una tematica (a cura del candidato) abstract tesi di laurea Conoscenza linguistica Lingue obbligatorie: INGLESE Ulteriore conoscenza linguistica: Nessuna altra lingua Dottorato straniero Presentazione: For the XXX PhD Programme, 5 positions are available for foreign candidates:- Two (2) of these positions are reserved to candidates supported by Marie Curie Initial Training Networks (ITN, Call: FP7- PEOPLE-2012-ITN) project entitled "A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. coli infections - DISCo, Proposal Number , in collaboration with Novartis Vaccines & Diagnostics (Siena, IT) and INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA, Clermont FR). Candidates will apply for one or both of the following projects:project 1- Identification of novel adhesins in pathogenic E. coli strains as a strategy for preventing intestinal colonization (Identificazione di nuove adesine in ceppi di E. coli patogeno come nuova strategia d inibizione della colonizzazione intestinale).project 2- Immunological

5 characterization of novel adjuvants for generation of vaccines against pathogenic E. coli strains (Caratterizzazione di nuovi adiuvanti per un vaccino universale contro E. coli patogeni). - Three (3) positions are reserved to candidates supported by fellowships from the IRAQ Government, within an framework agreement with Roma Tre University. Candidates must apply in one of the leading research area of the PhD Programme in Biomedical Sciences and Tecnologies, as outlined hereafter.phd Programme in BIOMEDICAL SCIENCES AND TECHNOLOGIES (BST)BST is an interdisciplinary PhD programme encompassing fundamental Chemical, Physical, Biological and Medical disciplines, including Inorganic and Organic Chemistry, Applied Physics, Biochemistry, Bioinformatics, General and Clinical Microbiology, Immunology, Microbial biotechnology, Molecular Biology, Pharmacology, Physiology, Pathology and Virology. The board of supervisors is composed of 16 internationally recognized experts. The programme is centred on the biomedical research, with particular regard to the biological basis of emerging and/or human pathologies, including infectious, metabolic end degenerative diseases. The student will benefit from the existence, within the doctoral programme, of areas of excellence in fundamental research as well as of the close cooperation existing between basic and translational research. Doctoral theses are prepared in laboratories with strong biomedical imprinting, in general involving multi-disciplinary research approaches, and benefit from the expertise and technical platforms developed by the fundamental sciences. Students will work in a creative environment with strong integration and cooperation between chemistry, physics and biomedical disciplines, often in collaboration with clinical centres. The course is aimed to developing professional skills and specialized knowledge for future career in of biomedical research. The programme includes two integrated curricula:1. Biophysical chemistry and Pharmacology 2. Physiology and Microbiology.The main research areas for BST are: Inorganic Chemistry: Nanomaterials for therapeutic applications. Synthesis, surface functionalization of metal nanoparticles. Structural and chemical characterization by XPS, SR- XPS, EXAFS, NEXAFS, IRRAS, DLS, ICP.Organic Chemistry: SAR studies in antioxidant lipophilic hydroxytyrosyl derivatives, also when supported on nanostructured particles; Enantioselective synthesis of 3- hydroxysubstituted-2(3h)-benzofuranons and -2(3H)-oxindoles as potential positive allosteric modulators of GABAB receptors.applied Physics: spectroscopic characterization of metalloproteins, and in particular of electron transfer proteins by EPR, Raman, and neutron scattering, supported by molecular dynamics simulations and

6 computational docking. A special attention is devoted to applications in the field of nanomedicine to develop ultra-sensitive detection methods by combining biorecognition processes with advanced nanoscopic techniques even coupled with computational approaches.biochemistry: Structure-function relationships of microbial proteins related to infectivity and pathogenicity; Studies on the mechanisms of enzymatic activities by time-resolved optical spectroscopy; Development of new methods for the determination of drugs, metabolites and infectious agents in biological fluids; Hemoproteins; Albumin; Structure and function characterization of heme-based oxygen carriers and electron transporters ; Physico-chemical characterization of ligand-dependent properties of human serum albumin; Characterization of functional and structural properties of active transient species of proteins; Characterization by X-ray crystallography and solution NMR of proteinprotein, protein-dna, and protein-ligand recognition.bioinformatics: Ab initio protein structure and function prediction of bacterial proteins for the development of drugs. Development of novel biomediators for the detection of pollutants of relevance to human health through protein engineering, protein design, molecular docking and molecular dynamics simulations. Development of software tools for protein structure analysis, protein function recognition and prediction of ligand binding sites.microbial biotechnology: Development, screening, and characterization of compounds and macromolecules endowed with biomedical and/or pharmaceutical interest; Characterization of bioactive compounds of microbial origin and of new antimicrobial agents. General and Medical Microbiology:Active transport mechanisms and their role in host-bacterium interactions; Regulation of microbial virulence genes through genomic, transcriptomic and proteomic approaches; Molecular and genetic basis of bacterial pathogenicity and of resistance to antimicrobial agents and to environmental stresses; Molecular typing and genomic evolution of bacterial pathogensmolecular Biology: Molecular Biology: Studies on the structure-function relationships in biological macromolecules; Molecular mechanisms of metabolic control in prokaryotes and eukaryotes; development of aptamer-based biochips for the detection of tumor antigens by RAMAN spectroscopy.physiology: Relationship between oxidative stress, ageing, cholesterol metabolism and hormones; Effects of natural and synthetic compounds on estrogen receptor alphadependent cell proliferation; Role of endocrine disruptors on estrogen receptor activities: putative gender-related susceptibility; Study of the antioxidant activity of diet-derived and synthetic compounds; Role of endocrine disruptors on differentiation and potential protective effects of

7 diet. Pharmacology: Behavioral and neurochemical effects of neuroactive drugs; Developmental neurotoxicity of drugs of abuse and environmental chemicals; Animal models of cognitive and emotional disorders as screening to identify novel pharmacological approaches to treat neuropsychiatric diseases; Parmacokinetic studies: drug absorption, distribution, metabolism and excretion; Drug binding to plasma proteins.virology and antimicrobial immunity: Virus-cell interactions in retroviral infections, HIV molecular biology, Antiviral innate immunity and viral immunoevasion; Biology of type-i interferons as effector and regulator of antimicrobial immunity; Viral oncogenesis. Altre informazioni: Candidates can get in touch by or Skype with the coordinator Prof. Paolo Visca (e.mail: skype: paolo.visca) for preliminary contacts and for any question regarding the course. Applications will be considered only if complete in any part. Prove concorsuali speciali Le prove saranno svolte secondo l'ordine indicato: 1) Valutazione titoli Please note that the XXX PhD Programme in Biomedical Sciences and Technologies will consider only:- Two (2) PhD candidates supported by Marie Curie Initial Training Networks (ITN, Call: FP7-PEOPLE-2012-ITN) project entitled "A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. coli infections - DISCo, Proposal Number , in collaboration with Novartis Vaccines & Diagnostics (Siena, IT) and INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA, Clermont FR). Project 1- Identification of novel adhesins in pathogenic E. coli strains as a strategy for preventing intestinal colonization (Identificazione di nuove adesine in ceppi di E. coli patogeno come nuova strategia d inibizione della colonizzazione intestinale).project 2- Immunological characterization of novel adjuvants for generation of vaccines against pathogenic E. coli strains (Caratterizzazione di nuovi adiuvanti per un vaccino universale contro E. coli patogeni). Three (3) PhD candidates selected by the IRAQ Government within a framework agreement with the Roma Tre university.a preliminary selection of candidates will be based on: 1) (mandatory) university (or equivalent) degree; 2)(mandatory) abstract of the final thesis; 3)(mandatory) list of passed examinations (with scores); 4) (mandatory) curriculum vitae et studiorum; 5)(mandatory) a proposed research project; 6) (mandatory) at least three reference

8 letters provided and signed by relevant members of the international scientific community, relating to the candidate s chosen course.after preliminary selection, only the eligible candidate(s) will be contacted from the Coordinator by for an oral interview by Skype.There are no available position reserved to foreign applicants, other than the 5 illustrated above. 2) Prova orale For the 2 PhD candidates supported by Marie Curie Initial Training Networks (ITN, Call: FP7-PEOPLE-2012-ITN) project entitled "A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. coli infections - DISCo, Proposal Number : only skype interview. For the 3 PhD candidates selected by the IRAQ Government: interview by skype on the proposed research programme. The selection of candidates will also be based on the consistency of their programme with the main research interests of the PhD Programme in Biomedical Sciences and Technologies.All candidates are requested to indicate their e- mail and skype address in their application (mandatory). Ulteriori informazioni: Informazioni e recapiti: dottorato.scienze@uniroma3.it Curriculum studiorum del candidato Voce data e voto di laurea elenco degli esami sostenuti e relative votazioni Modalità OBBLIGATORIO OBBLIGATORIO elenco cronologico di Borse di studio, Assegni di ricerca (et similia) percepiti Diplomi/certificati di conoscenza lingue estere Diplomi/attestati di partecipazione di corsi universitari post-lauream Attestati di partecipazione a gruppi di ricerca Attestati di partecipazione a stage Altri riconoscimenti (p. es.: premiazione in concorsi)

9 Documentazione richiesta abstract tesi di laurea progetto di ricerca prima lettera di presentazione (a cura di un docente) seconda lettera di presentazione (a cura di un docente) terza lettera di presentazione (a cura di un docente) elenco delle pubblicazioni descrizione delle precedenti esperienze di ricerca lettera di motivazione (a cura del candidato) indicazione di preferenza rispetto a una tematica (a cura del candidato)