1 ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Laboratori for Mother and Child Health Department of Public Health Via Giuseppe La Masa, Milano MI - Italy - tel fax CURRICULUM VITAE MAURIZIO BONATI March 2015 IRCCS Decreto Ministeriale 18 gennaio 2013 (Gazzetta Uff. N. 34 del 9/2/2013) I CONTRIBUTI PER LA RICERCA VERSATI ALL'ISTITUTO SONO FISCALMENTE DEDUCIBILI DAL REDDITO (Gazzetta Uff. N. 179 del 3/8/2011) FONDAZIONE PER RICERCHE ERETTA IN ENTE MORALE, D.P.R. 361 DEL 5/4/ REGISTRO PERSONE GIURIDICHE PREFETTURA MILANO N.227 CONTO CORRENTE POST. N COD. FISC. E PARTITA IVA ANAGRAFE NAZIONALE RICERCHE COD.G RECOGNIZED AS A TAX EXEMPT ORGANIZATION UNDER SECTION 501 (c)(3) OF THE USA INTERNAL REVENUE CODE-TAX I.D. No.: Sistema di gestione qualità certificato da Certiquality UNI EN ISO 9001:2008, progettazione ed erogazione di corsi di formazione specialistica nell ambito della biologia e della medicina
2 Curriculum Vitae Europass PERSONAL INFORMATION Surname(s) / First name(s) Address(es) Telephone(s) BONATI MAURIZIO IRCCS ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI VIA G. LA MASA, MILAN ITALY 02/ secretary Fax(es) 02/ Nationality Italian Date of birth 15 JULY 1954 DESIRED EMPLOYMENT / OCCUPATIONAL FIELD Clinical Epidemiology, Clinical Pharmacology/ Public Health, Pediatrics WORK EXPERIENCE Date Research Fellow at the "Mario Negri" Institute for Pharmacology Research, Milan, with the Laboratory of Neurochemistry Research Assistant at the "Mario Negri" Institute for Pharmacology Research, Milan, with the Laboratory of Clinical Pharmacology Head of Perinatal Clinical Pharmacology Unit at the "Mario Negri" Institute for Pharmacology Research, Milan Advisor to WHO for the Drug Utilization Research Group (in particular, drug use in pregnancy and in children) Coordinator of the International Cooperative Study of Drug Use in Pregnancy, under the auspices of WHO and the support of EEC Co-Director of the Health and Drug Information Centre (Centro di Informazione sul Farmaco e la Salute, CIFS) Co-Rditor di The Kangaroo 1993 to date Head of Laboratory for Mother and Child Health "Mario Negri" Institute for Pharmacology Research to date Teacher for the Lombardy region s professional training courses to date Teacher for the PhD course set up in collaboration with the UK s Open University. Permanent member of the international jury for the Colsubsidio Prize for Paediatric research (premio Colsubsidio de Investigación en Pediatria) Colombia
3 Co-ordinator of the Collaborative International Project for the creation of a clinical trial register on pediatric drug therapy trials (DEC-net) funded by the European Union (5 th Framework Programme) Director of the annual public health module of the Master s Course in Analysis and Management of Projects for Development of Milan s Università degli Studi (Political Science Faculty) to date Member of the Technical Committee for the processing and updating of the regional therapeutic formulary of the Autonomous region of the Aosta Valley to date Editor of scientific journal Ricerca & Pratica Teacher at the annual European course Evaluation of medicinal products in children (promoted ESDPPP and Eudipharm) to date Titolar Professor of the School of Specialisation in Paediatrics - University of Milan Bicocca to date Member of the National ADHD Register s scientific committee Member of the AIFA s Farmaci e bambini (Drugs and children) workgroup s scientific committee to date Member of the Lombardy Region s Regional Vaccine Commission Expert of the Higher Council of Health to date Member of the National Vaccine Commission to date Head of Department Public Health - "Mario Negri" Institute for Pharmacology Research 2010 to date Titolar Professor of the School of Specialization in Child and Adolescents Psychiatry and Neurology University of Pavia to date Co-ordinator of the Collaborative International Project Coordinating resources to assess and improve health status of migrants from Latin America, funded by the European Union (7 th Framework Programme). Official H index (Web of Science, September 2014): 32.0 Name and type of organisation providing IRCCS - Istituto di Ricerche Farmacologiche Mario Negri education and training Via G. La Masa, Milan Italy Type of business or sector A private foundation for the ill - clinical and community health research Main activities and responsibilities Head, Department of Public Health. Head, Laboratory for Mother and Child Health.
4 Social skills and competences Monitoring and epidemiological evaluation of drug utilisation and effects of drugs and vaccines in motherhood and childhood. Research methodology in general hospital and paediatric community practice. Transfer of information to the community. Epidemiology of paediatric and perinatal care. Collaboration (also with non-governmental organisations) in health related projects involving countries with limidet resources. Teacher in courses, Master s courses, and other national and international sociosanitary educational initiatives. Consultant for the World Health Organization (WHO), the European Medicines Agency (EMEA), and the Italian Drug Agency (AIFA). Editorial collaboration with national and international scientific journals. (Member of the editorial committees of : European Journal of Clinical Pharmacology; Paediatric & Perinatal Drug Therapy; Pediatric Health; Pediatria di São Paulo; Saludarte; Dialogo sui Farmaci; Disturbi d Attenzione e Iperattività; Quaderni ACP; Ricerca & Pratica). EDUCATION AND TRAINING Dates Title of qualification awarded Principal subjects/occupational skills covered Level in national or international classification M.D. degree at University of Milan In-hospital and out-hospital research PERSONAL SKILLS AND COMPETENCES Mother tongue(s) Other language(s) Italian language 1 English 2 Spanish Self-assessment Comprensione Speaking Writing European level (*) English Spanish Listening Reading Spoken interaction Spoken production Lettura 1 good 1 good 1 good 1 good 1 good 2 good 2 good 2 basic 2 basic 2 basic (*) Common European Framework of Reference for Languages COMMUNICATION AND SOCIAL SKILLS Ability to follow and train students, recent graduates, and researchers. Ability to communicate with, and teach, the scientific and lay public. ORGANISATIONAL SKILLS AND COMPETENCES Ability to organise scientific meetings, seminars, courses, and national and international initiativesi. TECHNICAL SKILLS AND COMPETENCES All technical and professional skills and competences necessary to plan the research I coordinate. ANNEXES Publications
5 Full Paper 1974 Algeri S, Bonati M, Ponzio F, Turner AJ. Dihydropteridine reductase: enzyme characteristics, regional distribution and ontogenic development. Br J Pharmacol 1974;52: Algeri S, Bonati M, Brunello N, Ponzio F. Dihydropterine reductase and tyrosine hydroxylase activities in rat brain during development and senescence study. Brain Res 1977;132: Altamura AC, Bonati M, Brunello N, Giordano PL, Algeri S. The activity of some neurotransmittersynthetizing enzymes in experimental cobalt epilepsy. Neurosci Lett 1978;7: Latini R, Assael BM, Bonati M, Caccamo ML, Gerna M, Mandelli M, Marini A, Sereni F, Tognoni G. Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn. Eur J Clin Pharmacol 1978;13: Latini R, Bonati M, Castelli D, Garattini S. Dose-dependent kinetics of caffeine in rats. Toxicol Lett 1978;2: Bonati M, Castelli D, Latini R, Garattini S. Comparison of gas-liquid chromatography with nitrogenphosphorus selective detection and high-performance liquid chromatography methods for caffeine determination in plasma and tissues. J Chromatogr 1979;164: Bonati M, Latini R, Marzi E, Cantoni R, Belvedere G. [2-14C]-Caffeine metabolism in control and 2- methylcholanthrene induced rat liver microsomes by high presure liquid chromatography. Toxicol Lett 1980;7:1-7. Latini R, Bonati M, Marzi E, Tacconi M.T, Sadurska B, Bizzi A. Caffeine disposition and effects in young and one year old rats. J Pharm Pharmacol 1980;32: Tognoni G, Bellantuono C, Bonati M, D'Incalci M, Gerna M, Latini R, Mandelli M, Porro M.G, Riva E. Clinical relevance of pharmacokinetics. Clin Pharmacokinet 1980;5: Bonati M, Latini R, Marra G, Assael B.M, Parini R. Theophylline metabolism during the first month of life and development. Pediatr Res 1981;15: Bonati M, Latini R, Marra G, Assael B.M, Parini R. Theophylline distribution in the premature neonate. Dev Pharmacol Ther 1981;3: Latini R, Bonati M, Marzi E, Garattini S. Urinary excretion of an uracilic metabolite from caffeine by rat, monkey and man. Toxicol Lett 1981;7: Bonati M, Kanto J, Tognoni G. Clinical pharmacokinetics of cerebrospinal fluid. Clin Pharmacokinet 1982;7: Bonati M, Latini R, Galletti F, Young JF, Tognoni G, Garattini S. Caffeine disposition after oral doses. Clin Pharmacol Ther 1982;32:
6 1983 Gaspari F, Celardo A, Bonati M. Apparent dissociation constants of some possible uracil metabolites of methylxanthines. Anal Lett 1983;16: Bonati M, Bortolotti A, Jiritano L, Latini R, Garattini S. Disposition of 6-amino-5(N-methylformilamino) 1,3-dimethyluracil, one of the primary metabolites of caffeine, in the rat. Drug Metab Dispos 1983;11: Bonati M, D'Aranno V, Galletti F, Fortunati M.T, Tognoni G. Acute overdosage of amiodarone in a suicide attempt. J Toxicol Clin Toxicol 1983;20: Bonati M, Galletti F, Volpi A, Cumetti C, Rumolo R, Tognoni G. Amiodarone in patients on long-terms dialysis. New Engl J Med 1983;308:906. Peri G, Polentarutti B, Filippeschi S, Malfiore C, Amato G, Pepe S, Bonati M, Garattini S, Mantovani A. In vivo and in vitro cytotoxicity of possible uracil metabolites of methylxanthines. Toxicol Lett 1983;18: Bonati M, Tognoni G. Has clinical pharmacology lost its way? Lancet 1984;1: Bonati M, Celardo A, Galletti F, Latini R, Tursi F, Belvedere G. Kinetics of caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes. Toxicol Lett 1984;21: Airoldi L, Macrì A, Bonfanti M, Bonati M, Fanelli R. Kinetics and biovailability of N- nitrosodiethanolamine after intravenous and cutaneous administration to rats. Fd Chem Toxic 1984;22: Bonati M, Latini R, Sadurska B, Riva E, Galletti F, Borzelleca JE, Tarka S.M, Arnaud MJ, Garattini S. I: Kinetics and metabolism of theobromine in male rats. Toxicology 1984;30: Latini R, Bonati M, Gaspari F, Traina GL, Jiritano L, Bortolotti A, Borzelleca JF, Tarka SM, Arnaud MJ, Garattini S. II. Kinetics and metabolism of theobromine in male and female non pregnat and pregnant rabbits. Toxicology 1984;30: Bonati M, Gaspari F, Benfenati E, Neyroz P, D'Aranno E, Galletti F, Tognoni G. Physicochemical and analytical characteristics of amiodarone. J Pharm Sci 1984;73: Cerletti C, Bonati M, Del Maschio A, Galletti F, Dejana E, Tognoni G, De Gaetano G. Plasma levels of salycylate and aspirin in healthy subjects relevance to drug interaction on platelet function. J Lab Clin Med 1984;103: Traina GL, Bonati M. Pharmacokinetics of teicoplanin in man after intravenous administration. J Pharmacokinet Biop 1984;12: Bonati M, Latini R, Tognoni G, Young JF, Garattini S. Interspecies comparison of in vivo caffeine pharmacokinetics in man, monkey, rabbit, rat and mouse. Drug Metab Rev 1984;15: Bortolotti A, Jiritano L, Bonati M. Pharmacokinetics of paraxanthine, one of the primary metabolites of caffeine, in the rat. Drug Metab Dispos 1985;13: Neyroz P, Bonati M. In vitro amiodarone protein binding and its interaction with warfarin. Experientia 1985;4:
7 Traina GL, Bonati M. Pharmacokinetics of theobromine and its metabolites in rabbits. J Pharmacokinet Biop 1985;13: Bonati M, Gaspari F, Traina GL, Tognoni G. Therapeutic drug monitoring. J Clin Immunoassay 1985;8: Gaspari F, Marraro G, Penna GF, Valsecchi R, Bonati M. Elimination kinetics of thiopentone in mothers and their newborn infants. Eur J Clin Pharmacol 1985;28: Snidero M, Traina GL, Bonati M. Ambulatory therapeutic digoxin monitoring. Drug Intell Clin Pharm 1985;19: Bortolotti A, Bonati M. Pharmacokinetics of theobromine in male rats in different traumatic conditions. Res Commun Chem Pathol Pharmacol 1985;50: Bonati M, Castelli D, Leone N, Perucca E, Tognoni G. Antiepileptic drug monitoring. Drug Intell Clin Pharm 1985;19: Jiritano L, Bortolotti A, Gaspari F, Bonati M. Caffeine disposition after oral administration to pregnant rats. Xenobiotica 1985;15: Bonati M, Jiritano L, Bortolotti A, Gaspari F, Filippeschi S, Puigdemont A, Garattini S. Caffeine distribution in acute toxic response among inbred mice. Toxicol Lett 1985;29: Tognoni G, Bandera L, Bonati M, Franzosi MG, Kasilo O. An action program for clinical pharmacology. Revista de Farmacologia Clinica y Experimental 1985;2: Celardo A, Traina GL, Jankowski A, Bonati M. Pharmacokinetics of theophylline and its metabolites in rabbits. Eur J Drug Metab Pharmacokinet 1985;10: Bonati M, Traina GL, Colombo F, Tognoni G. Digoxin serum requests. Lancet 1986;i: Jiritano L, Bortolotti A, Bonati M. The effect of chronic oral ketoconazole on in vivo drug metabolism in the rat. Res Commun Chem Pathol Pharmacol 1986;54: Tognoni G, Bonati M. Second-generation clinical pharmacology. Lancet 1986;ii: Traina GL, Celardo A, Arboix M, Bonati M. Experimental model for pharmacokinetic studies during continuous peritoneal dialysis in the rabbit. J Pharmacol Methods 1986;15: Traina GL, Gentile MG, Fellin G, Rosina R, Cavenaghi L, Buniva G, Bonati M. Pharmacokinetics of teicoplanin in patients on continuous ambulatory peritoneal dialysis. Eur J Clin Pharmacol 1986;31: Gaspari F, Bonati M. Quantitative relationships between physicochemical characteristics and pharmacokinetics of caffeine and its metabolites in the rat. J Pharm Pharmacol 1987;39: Bonati M, Traina GL, Villa G, Salvadeo A, Gentile M.G, Fellin G, Rosina R, Cavenaghi L, Buniva G. Teicoplanin pharmacokinetics in patients with chronic renal failure. Clin Pharmacokinet 1987;12: Gaspari F, Viganò G, Orisio S, Bonati M, Livio M, Remuzzi G. Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition. J Clin Invest 1987;79:
8 Celardo A, Traina GL, Arboix M, Puigdemont A, Bonati M. Pharmacokinetic and pharmacodynamic modelling of atenolol in rabbits mantained on continuous peritoneal dyalisis. Eur J Drug Metab Pharmacokinet 1987;12: Guaitani A, Abbruzzi R, Bastone A, Bianchi M, Bonati M, Catalani R, Latini R, Pantarotto C, Szczawinska K. Metabolism of caffeine to 6-amino-5-[N-Methylformylamino]-1,3-dimethyluracil in the isolated, perfused liver from control, phenobarbital-, ß-naphthoflavone- and 3-methylcholanthrenepretreated rats. Toxicol Lett 1987;38: Farina M.L, Bonati M, Iapichino G, Pesenti A, Procaccio F, Boselli L, Langer M, Graziina A, Tognoni G. Clinical Pharmacological and Therapeutic Considerations in General Intensive Care. Drugs 1987;34: Sangalli L, Bonati M. Reversed-phase high performance liquid chromatography determination of cyclosporine in human blood. Ther Drug Monit 1987;9: Bonati M, Brambilla C, Colombo F, Tognoni G, Italian Collaborative Group on Preterm Delivery. Early neonatal drug utilization in preterm newborns in neonatal intensive care units. Dev Pharmacol Ther 1988;11:1-7. Bonati M, Traina GL, Rosina R, Buniva G. Pharmacokinetics of a single intravenous dose of teicoplanin in subjects with various degrees of renal impairment. J Antimicrob Chemoth 1988;21(Suppl. A): Bonati M, Garattini G. Pharmacokinetics of caffeine. ISI Atlas of Science. Pharmacology 1988;1: Bonati M, Traina GL, Colombo F, Gaspari F, Tognoni G, Italian Collaborative Group on Therapeutic Drug Monitoring. Italian collaborative study on the utilization of therapeutic drug monitoring in hospital departments. Ther Drug Monit 1988;10: Bonfanti M, Magagnotti C, Bonati M, Fanelli R, Airoldi L. Pharmacokinetic profile and metabolism of N-nitrosobutyl(4-hydroxybutyl)amine in rats. Cancer Res 1988;48: Italian Collaborative Group on Preterm Delivery, Bonati M, Brambilla C, Colombo F, Tognoni G. Prenatal and postnatal factors affecting short-term survival of very-low-birthweight infants. Eur J Pediatr 1988;147: Kasilo O, Romero M, Bonati M, Tognoni G. Information on drug use in pregnancy from the viewpoint regional drug information centre. Eur J Clin Pharmacol 1988;35: Largaespada MJ, Pistotti V, Bonati M. How accurate are bibliografic data bases? Lancet 1988;1:538. Traina GL, Gentile MG, Fellin G, Rosina R, Cavenaghi L, Buniva G, Bonati M. Pharmacokinetics of intraperitoneal teicoplanin in patients with chronic renal failure on continuous ambulatory peritoneal dialysis. Br J Clin Pharmacol 1988;25: Sangalli L, Bortolotti A, Jiritano L, Bonati M. Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans. Drug Metab Dispos 1988;16: Viganò G, Gaspari F, Locatelli M, Pusineri F, Bonati M, Remuzzi G. Dose-effect and pharmacokinetics of estrogens given to correct bleeding time in uremia. Kidney Int 1988;34: Celardo A, Bortolotti A, Benfenati E, Bonati M. Measurement of vitamin E in premature infants by reversed-phase high-performance liquid chromatography. J Chromatogr 1989;490:
9 Puigdemont A, Arboix M, Gaspari F, Bortolotti A, Bonati M. In vitro plasma protein binding of propafenone and protein profile in eight mammalian species. Res Commun Chem Pathol Pharmacol 1989;64: Pedraz JL, Calvo B, Bortolotti A, Celardo A, Bonati M. Bioavailability of intramuscular vitamin E acetate in rabbits. J Pharm Pharmacol 1989;41: Bortolotti A, Castelli D, Verotta D, Bonati M. Pharmacokinetic and pharmacodynamic modelling of metoprolol in rabbits with liver failure. Eur J Drug Metab Pharmacokinet 1989;14: Bortolotti A, Castelli D, Bonati M. Hematology and serum chemistry of adult, pregnant and newborn New Zealand rabbits (Oryctolagus cuniculus). Lab Animal Sci 1989;39: Celardo A, Passerini F, Bonati M. Placental transfer and tissue distribution of thiopental in the pregnant rat. J Pharmacokinet Biop 1989;17: Sangalli L, Bortolotti A, Passerini F, Bonati M. Placental transfer, tissue distribution, and pharmacokinetics of cyclosporine in the pregnant rabbit. Drug Metab Dispos 1990;18: Bonati M. Is it time for a registry of clinical trials in pediatrics? J Pediatr 1990;115: Bonati M, Bortolus R, Marchetti F, Romero M, Tognoni G. Drug use in pregnancy:an overview of epidemiological (drug utilization) studies. Eur J Clin Pharmacol 1990;38: Celardo A, Bonati M. Determination of thiopental measured in human blood by reversed-phase highperformance liquid chromatography. J Chromatogr 1990;527: Collaborative Group on Drug Use in Pregnancy, Bonati M, Tognoni G. Drug Use in Pregnancy: a preliminary report of the international cooperative drug utilization study. Pharm Weekbl Sci 1990;12: Gaspari F, Bonati M. Interspecies comparison of theophylline disposition. Drug Metab Rev 1990;22: Bonati M, Marraro G, Celardo A, Passerini F, Schieroni F, Spada P, Valsecchi R, De Capitani E. Thiopental efficacy in phenobarbital-resistant neonatal seizures. Dev Pharmacol Therap 1990;15: Bonati M, Marchetti F, Zullini MT, Pistotti V, Tognoni G. Adverse drug reactions in neonatal intensive care units. Adverse Drug React Acute Poisoning Rev 1990;9: Bortolotti A, Traina GL, Guaitani A, Marzi E, Latini R, Young JF, Bonati M. In- vivo and perfused liver caffeine kinetics in the rat. Res Commun Chem Pathol Pharmacol 1990;69: Bortolotti A, Traina GL, Barzago MM, Bonati M. Placental transfer and tissue distribution of vitamin E in pregnant rabbits. Biopharm Drug Dispos 1990;11: Aramayona JJ, Bonati M, Bortolotti A, Castelli D, Gaspari F, Lucchini G. Plasma protein binding of theophylline during development in the rabbit. Biol Neonate 1991;60: Bonati M, Balocco R, Colombo A, Pistotti V. A computer filing system for drug use in a pregnancy consultation service. Comput Methods Programs Biomed 1991;35: Bonati M, Fellin G, ICGDUP. Changes in smoking and drinking behavior before and during pregnancy in Italian mothers: implications for public health intervention. Int J Epidemiol 1991;20:
10 Bonati M, Marchetti F, Tognoni G. Management of convulsions with fever. BMJ 1991;303:1135. Bortolotti A, Corada M, Barzago MM, Celardo A, Guaitani A, Bonati M. Pharmacokinetics of theophylline in the newborn and adult rabbit. Drug Metab Dispos 1991;19: Celardo A, Dell'Elba G, Frassanito R, Benfenati E, Bonati M. Simultaneous determination of isbufylline and its major metabolites in blood and urine by reversed-phase high-performance liquid chromatography. J Chromatogr 1991;568: Clinical Pharmacology and Toxicology Study Group, Italian Society for Clinical Biochemistry. Interlaboratory variability in drug assay: A comparison of quality control data with reanalysis of routine patient samples. I: Anticonvulsant drugs and theophylline. Ther Drug Monit 1991;13: Clinical Pharmacology and Toxicology Study Group, Italian Society for Clinical Biochemistry. Interlaboratory variability in drug assay: A comparison of quality control data with reanalysis of routine patient samples. II: Digoxin. Ther Drug Monit 1991;13: Collaborative Group on Drug Use in Pregnancy (CGDUP). An international survey on drug utilization during pregnancy. Int J Risk Saf Med 1991;2: Italian Collaborative Group on Preterm Delivery. Absorption of intramuscular vitamin E in premature babies. Dev Pharmacol Therap 1991;16: Omarini D, Barzago MM, Bortolotti A, Aramayona JJ, Bonati M. Placental transfer of theophylline during in-situ perfusion in the rabbit. J Pharm Methods 1991;25: Alli C, Avanzini F, Bettelli G, Bonati M, Colombo F, Corso R, Di Tullio M, Gentile MG, Sangalli L, Taioli E, Tognoni G, et al. Feasibility of long-term low-sodium diet in mild hypertension. J Hum Hypertens 1992;6: Balocco R, Bonati M. Mefloquine prophylaxis against malaria for female travellers of childbearing age. Lancet 1992;340: Barzago MM, Bortolotti A, Omarini D, Aramayona JJ, Bonati M. Monitoring of blood gas parameters and acid-base balance of pregnant and non-pregnant rabbits (Oryctolagus cuniculus) in routine experimental conditions. Lab Anim 1992;26: Barzago MM, Omarini D, Aramayona J, Bonati M. In situ perfusion in the rabbit: effects of different umbilical flow rates on placental transfer of compounds. J Pharm Methods 1992;27: Bonati M, Balocco R. Infants with low birth weight in developing countries. The Kangaroo 1992;1: Bonati M, Marchetti F, Pistotti V, Agostini M, Bisogno G, Bussi R, Davico S, De Santis M, Forno S, Gangemi M, Merlin D, Merlo M, Murgia V, Pivetta S, Raimo F, Tamburlini G. Meta-analysis of antimicrobial prophylaxis for recurrent acute otitis media. Clin Trials and Meta-Analysis 1992;28: Bonati M, Tognoni G. Drug Use in Pregnancy (DUP) Study. The Prescriber, Newsletter UNICEF 1992;1:2-3. Celardo A, Dell'Elba G, Bonati M. Bioavailability of oral isbufylline in rabbits. Eur J Drug Metab Pharmacokinet 1992;17: Collaborative Group on Drug Use in Pregnancy (CGDUP). An international survey on drug utilization during pregnancy (PROFILE). Int J Risk Saf Med 1992;3:49-52.
11 Collaborative Group on Drug Use in Pregnancy (CGDUP). Medication during pregnancy: an intercontinental cooperative study. Int J Gynaecol Obstet 1992;39: Corada M, Bortolotti A, Barzago MM, Celardo A, Bonati M, Guaitani A. Pharmacokinetic profile of theophylline in isolated perfused liver of rabbits at different ages. Development of drug metabolizing activity during ontogenesis. Drug Metab Dispos 1992;20: Omarini D, Pistotti V, Bonati M. Placental perfusion: an overview of the literature. J Pharm Methods 1992;28: Omarini D, Barzago MM, Aramayona J, Bortolotti A, Lucchini G, Bonati M. Theophylline transfer across human placental cotyledon during in vitro dual perfusion. J Med 1992;23: Bortolotti A, Lucchini G, Barzago MM, Stellari F, Bonati M. Simultaneous determination of retinol, μ- tocopherol and retinyl palmitate in plasma of premature newborns by reversed-phase high-performance liquid chromatography. J Chromatogr 1993;617: Brucato A, Bonati M, Gaspari F, Colussi G, Giachetti M, Zoppi F, Ruggerone ML. Tetany and rhabdomyolysis due to surreptitious furosemide - importance of magnesium supplementation. Clin Toxicology 1993;31: Italian Collaborative Group on Preterm Delivery (ICGPD). Supplementation and plasma levels of vitamin A in premature newborns at risk for chronic lung disease. Dev Pharmacol Ther 1993;20: Marchetti F, Romero M, Bonati M, Tognoni G. The use of psychotropic drugs during pregnancy: a report of the international co-operative drug use in pregnancy (DUP) study. Eur J Clin Pharmacol 1993;45: Omarini D, Barzago MM, Bortolotti A, Lucchini G, Stellari F, Efrati S, Bonati M. Placental transfer of theophylline in an in vitro closed perfusion system by human placenta isolated lobule. Eur J Drug Metab Pharmacokinet 1993;18: Zullini MT, Bonati M. Geographical bias of prognostic scoring systems? Lancet 1993;342: Barzago MM, Bortolotti A, Stellari FF, Pagani C, Marraro G, Bonati M. Respiratory and hemodynamic functions, blood-gas parameters and acid-base balance of anesthetized guine pigs. Lab Anim Sci 1994;44: Barzago MM, Omarini D, Bortolotti A, Stellari FF, Lucchini G, Efrati S, Bonati M. Mefloquine transfer during in-vitro human placenta perfusion. J Pharmacol Exp Ther 1994;269: Bonati M. Epidemiological evaluation of drug utilization in children. J Clin Pharmacol 1994;34: Bonati M, Nannini S, Addis A. Vitamin A supplementation during pregnancy in developed countries. Lancet 1995;345: Addis A, Impicciatore P, Miglio D, Da Silva CDC, Colombo F, Bonati M. Drug Use in Pregnancy and lactation: the Work of a Regional Drug Information Centre. Ann Pharmacother 1995;29: Di Cerbo A, Di Paola R, Bonati M, Zingrillo M, De Filippis V, Corda D. Subgroups of graves' patients identified on the basis of biochemical activities of their immunoglobulins. J Clin Endocrinol Metab 1995;80:
12 Marchetti F, Bonati M, La Gamba G, Biasini G, Tognoni G, Italian Collaborative Group on Paediatric Chronic Diseases Parental and primary care physicians' views on the management of chronic diseases: a study in Italy. Acta Paediatr 1995;84: Barzago MM, Bortolotti A, Stellari FF, Diomede L, Algeri M, Efrati S, Salmona M, Bonati M. Placental transfer of valproic acid (VPA) after liposome encapsulation during in vitro human placenta perfusion. J Pharmacol Exp Ther 1996;277: Bonati M, Forte GB, De Joncheere K, Magnusson E. Drug donation to Bosnia-Hercegovina are often inappropriate. BMJ 1996;313:1011. Bonati M, Tamburlini G. Components of acellular pertussis vaccines. Lancet 1996;347: Italian Collaborative Group on Preterm Delivery (ICGPD). Vitamin A supplementation in premature neonates with postnatal lung injury. Int J Clin Pharm Ther 1996;34: Bonati M, Bosetti C, Ferraro R, Miglio D, Sanvito E, Violante A. The Southern Italy Neonatal Intensive Care Units Network: very low birth-weight outcomes for J Epidemiol Biostat 1997;2: Campomori A, Bonati M. Fluconazole treatment for vulvovaginal candidiasis during pregnancy. Ann Pharmacother 1997;31: Impicciatore P, Nannini S, Pandolfini C, Bonati M. Mothers' knowledge, attitudes toward, and management of fever in preschool children in Italy. Prev Med 1998;27: Impicciatore P, Pandolfini C, Casella N, Bonati M. Reliability of public-oriented health care resources on the World Wide Web the home management of fever in children. BMJ 1997;314: Impicciatore P, Violante A, Bonati M. Helping parents to cope when their preschool children are acutely ill. BMJ 1997;314:373. Bailey B, Addis A, Lee A, Sanghvi K, Mastroiacovo P, Mazzone T, Bonati M, Paolini C, Garbis H, Val T, De Souza CFM, Matsui D, Schechtman AS, Conover B, Lau M, Koren G. Cisapride use during human pregnancy: a prospective, controlled multicenter study. Digest Dis Sci 1997;42(9): Barbui C, Campomori A, Bonati M. Clozapine and blood dyscrasias different from agranulocytosis. Can J Psychiat 1997;42: Barbui C, Campomori A, Bonati M. Clozapine and non-granulocyte blood dyscrasias. BODHY 1997;18: Zullini MT, Bonati M, Sanvito E, Paulista Collaborative Group on Neonatal Care. Survival in neonatal intensive care units. A survey of nine centers in São Paulo, Brazil. Revista Panamericana de Salud Publica 1997;2(5): Bonati M, Addis A. Informing women about drugs they take during pregnancy: promoting consumers drug information as integral part of care. Pharm World Sci 1998;20: Bonati M, Impicciatore P, Pandolfini C. Quality on the Internet. BMJ 1998;317:1501. Lalkin A, Loebstein R, Addis A, Ramezani-Namin F, Magee LA, Mastroiacovo P, Mazzone T, Vial T, Bonati M, Koren G. The safety of omeprazole during pregnancy: a multi-center prospective controlled study. Am J Obstet Gynaecol 1998;179: