«Fiera delle idee» PO FESR SICILIA Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania

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1 «Fiera delle idee» PO FESR SICILIA Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania Presenter: Dr. Giulia Russo, giulia.russo@unict.it - University of Catania, Italy

2 Who we are The Computational modeling in systems biomedicine group is a research group of the University of Catania leaded by Francesco Pappalardo, professor of Computer Science. Our research goal is to show that mathematical/computational models can help the understanding of biological processes and the designing of new experiments. Presently we are leaders in the field of computational modeling in systems biology and medicine. Specifically we are one of the few groups in the world that validated in vivo the computational predictions. Group members: - Prof. Francesco Pappalardo, Professor of Computer Science, Group leader - Prof. Santo Motta, retired Professor of Mathematical Physics - Dr. Marzio Pennisi, Postdoc fellow - Dr. Giulia Russo, PhD student Some selected publications A computational model to predict the immune system activation by citrus derived vaccine adjuvants. Bioinformatics, 32(17): , In silico modeling and in vivo efficacy of cancer-preventive vaccinations. Cancer Research, 70(20): , Formal analysis of the surgical pathway and development of a new software tool to assist surgeons in the decision making in primary breast surgery. The Breast, 29:74 81, Computational modeling in melanoma for novel drug discovery. Expert Opinion on Drug Discovery, 11(6): , apr Agent based modeling of the effects of potential treatments over the blood-brain barrier in multiple sclerosis. Journal of Immunological Methods, 427:6 12, Computational modeling of the expansion of human cord blood CD133+ hematopoietic stem/progenitor cells with different cytokine combinations. Bioinformatics, 31(15): , 2015 «Fiera delle idee» PO FESR SICILIA , Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania

3 What we offer Cancer immunoprevention and immunotherapies modeling applications Behavioral analysis (immunodeficiencies, partial protection, high-replicating virus subtypes, personal resistance to virus strains) Modeling autoimmunity and target therapies in autoimmune diseases Analyzing the effect of several antiviral/vaccine treatments and/or combination(s) Suggesting new treatments/vaccination protocols Drug combination evaluation in treating disease Pathway complex analysis to suggest new molecular targets in precision medicine Doctors oriented software tool to assist patients and surgeons in taking proper decisions in clinical settings «Fiera delle idee» PO FESR SICILIA , Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania

4 Identification of the main target(s) of the problem Analysis of the available biomedical data Conceptual modeling Development & tuning of the model with the available data Biomedical people check Testing the model to reproduce previous experiments (if available) Using the model to achieve the goals Analysis of the biomedical problem Lab test of model prediction(s) «Fiera delle idee» PO FESR SICILIA , Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania

5 «Fiera delle idee» PO FESR SICILIA , Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania

6 «Fiera delle idee» PO FESR SICILIA , Catania, 31 gennaio 2017, Dipartimento di Fisica e Astronomia, Università degli Studi di Catania COMPUTATIONAL MODELING IN SYSTEMS BIOMEDICINE GROUP UNICT PO FESR SICILIA Metodologie e tecnologie per la prevenzione Metodologie e tecnologie per la diagnosi ASSE1: Ricerca, Sviluppo Tecnologico e Innovazione Metodologie e tecnologie per terapie innovative e/o avanzate Sensoristica, dispositivi e E-health Strategia Regionale S3, Ambito SCIENZE DELLA VITA Sviluppo del farmaco OMICS e bioinformatica applicata alle Omics