PROF. MICHELE TINAZZI CURRICULUM VITAE

PROF. MICHELE TINAZZI CURRICULUM VITAE Nato a Verona il 05.02.1965 Recapito: via Angelo Messedaglia n 2, 37069, Villafranca, Verona (VR) Codice Fiscale: TNZMHL65B05L781D E-mail: micheletinazzi@libero.it 1991: Laurea In Medicina e Chirurgia (110/110 e Lode), Università di Verona 1995: Specializzazione in Neurologia (50/50 e Lode), Università di Verona 1999: Dirigente Medico I Livello, UO Neurologia, Azienda Ospedaliera-Universitaria di Verona 2003: Dottorato in Neuroriabilitazione, Università di Verona 2003: Idoneità Professore Associato di Neurologia dal 2011: Coordinatore del Corso di Dottorato in Neuroscienze, Università di Verona Posizione attuale: Professore Associato di Neurologia (dal 30.12.04), presso il Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Università di Verona Campi di Interesse Clinico: Malattia di Parkinson e Disordini del Movimento: Responsabile dell Unità Semplice Centro Parkinson presso l Azienda Ospedaliera-Universitaria di Verona; Malattie cerebrovascolari: Collaboratore all interno del Gruppo Stroke Unit di Verona; Dolore. Campi di Interesse Scientifico: Malattia di Parkinson, Disordini del Movimento, Dolore e Plasticità Esperienze lavorative all estero: Attività clinica e di ricerca sulla fisiologia del movimento e del dolore mediante studio dei potenziali evocati presso il Functional Neurophysiological Institute of Lyon Hospital 1

(France) nel 1993-1994; Attività clinica e di ricerca nell ambito dei Disordini del Movimento presso il National Institute of Neurology, Queen Square, London nel 2004. Attività scientifica: autore o coautore di 130 contributi scientifici di cui 120 su riviste internazionali indicizzate; collabora come Referee con diverse riviste di neurologia e di neurofisiologia tra cui Brain, Neurology, Movement Disorders, J Neuroscience, Neuroimage, Pain, Experimental Brain Research, European J Neuroscience, Neuroscience Letters, Clinical Neurophysiology. Incarichi a Società Scientifiche: - 2005-2007 Revisore dei Conti della LIMPE; - 2007-2009 Consigliere della DISMOV-SIN; - 2009 - ottobre 2011 Segretario/Tesoriere della DISMOV-SIN. Collaborazioni Scientifiche: - Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milano - Centro Parkinson, Istituti Clinici di Perfezionamento, Milano - Cinica Neurologica Policlinico, Università di Milano - Divisione di Neurologia, Istituto San Raffaele, Milano - Dipartimento di Neuroscienze, Università di Torino - Dipartimento di Neuroscienze, Università di Genova - IRCCS Istituto di Neurologia Fondazione C. Mondino, Università di Pavia - Clinica Neurologica, Università di Brescia - Clinica Neurologica, Università di Padova - Clinica Neurologica, Università di Modena - Clinica Neurologica, Università di Pisa - Clinica Neurologica, Università di Siena - Dipartimento di Psicologia, Università di Roma La Sapienza e Fondazione Santa Lucia, Roma. - Dipartimento di Scienze Neurologiche e Istituto NEUROMED (IRCCS), Università di Roma La Sapienza - IRCCS CSS, Istituto Mendel, Roma - Divisione di Neurologia, Ospedale Pediatrico Bambino Gesù, IRCCS, Roma - Clinica Neurologica, Università di Chieti - Dipartimento di Neuroscienze, Università di Napoli - Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Bari - Clinica Neurologica, Università di Messina 2

- Clinica Neurologica, Università di Catania - Dipartimento di Neuroscienze, Università di Cagliari - Department of Clinic Genetics, Erasmus MC, Rotterdam, Netherland - Sobell Department of Motor Neuroscience and Movement Disorders and Institute of Neurology, London, UK - MRC Human Movement and Balance Unit, Institute of Neurology, London, UK - Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London, UK - Department of Medical Genetics, University of Tuebingen, Germany PUBBLICAZIONI SCIENTIFICHE (2006-2011) 1. FIORIO M, TINAZZI M, AGLIOTI SM. Selective impairment of hand mental rotation in patients with focal hand dystonia. Brain 2006; 129: 47-54. 2. GAMBARIN M, ANTONINI A, MORETTO G, BOVI P, ROMITO S, FIASCHI A, TINAZZI M. Pisa syndrome without neuroleptic exposure in a patient with parkinson s disease: case report. Mov Disord 2006; 21: 270-273. 3. DI FONZO A, TASSORELLI C, DE MARI M, CHIEN HF, FERREIRA J, ROHE CF, RIBOLDAZZI G, ANTONINI A, ALBANI G, MAURO A, MARCONI R, ABBRUZZESE G, LOPIANO L, FINCATI E, GUIDI M, MARINI P, STOCCHI F, ONOFRJ M, TONI V, TINAZZI M, FABBRINI G, LAMBERTI P, VANACORE N, MECO G, LEITNER P, UITTI RJ, WSZOLEK ZK, GASSER T, SIMONS EJ, BREEDVELD GJ, GOLDWURM S, PEZZOLI G, SAMPAIO C, BARBOSA E, MARTIGNONI E, OOSTRA BA, BONIFATI V; ITALIAN PARKINSON'S GENETICS NETWORK. Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet 2006; 14: 322-333. 4. TINAZZI M, DEL VESCO C, FINCATI E, OTTAVIANI S, SMANIA N, MORETTO G, FIASCHI A, MARTINO D, DEFAZIO G. Pain and motor complications in Parkinson's disease. J Neurol Neurosurg Psychiatry 2006 ;77: 822-825. 5. VALERIANI M, TONALI P, LE PERA D, RESTUCCIA D, DE ARMAS L, DEL VESCO C, MILIUCCI R, FIASCHI A, VIGEVANO F, ARENDT-NIELSEN L, TINAZZI M. Modulation of laser-evoked potentials by experimental cutaneous tonic pain. Neuroscience 2006; 140: 1301-1310. 3

6. MARONGIU R, GHEZZI D, IALONGO T, SOLETI F, ELIA A, CAVONE S, ALBANESE A, ALTAVISTA MC, BARONE P, BRUSA L, CORTELLI P, PETROZZI L, SCAGLIONE C, STANZIONE P, TINAZZI M, ZEVIANI M, DALLAPICCOLA B, BENTIVOGLIO AR, VALENTE EM, GARAVAGLIA B; ITALIAN PD STUDY GROUP. Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease. Mov Disord 2006; 21: 1232-1235. 7. TINAZZI M, FIORIO M, STANZANI C, MORETTO G, SMANIA N, FIASCHI A, BHATIA KP, ROTHWELL JC. Temporal discrimination of two passive movements in writer's cramp. Mov Disord 2006; 21: 1131-1135. 8. GAMBARIN M, VALENTE EM, LIBERINI P, BARRANO G, BONIZZATO A, PADOVANI A, MORETTO G, FIORIO M, DALLAPICCOLA B, SMANIA N, FIASCHI A, TINAZZI M. Atypical phenotypes and clinical variability in a large Italian family with DYT1-primary torsion dystonia. Mov Disord 2006; 21: 1782-1784. 9. TINAZZI M, ZARATTINI S, VALERIANI M, STANZANI C, MORETTO G, SMANIA N, FIASCHI A, ABBRUZZESE G. Effects of transcutaneous electrical nerve stimulation on motor cortex excitability in writer's cramp: Neurophysiological and clinical correlations. Mov Disord 2006; 21: 1131-1135. 10. GAMBARIN M, TINAZZI M. Reply: Pisa sindrome without neuroleptic exposure in a patient with Parkinson s disease: A case report. Mov Disord 2006; 21: 2264-2265. 11. SMANIA N, AGLIOTI SM, GIRARDI F, TINAZZI M, FIASCHI A, COSENTINO A, CORATO E. Rehabilitation of limb apraxia improves daily life activities in patients with stroke. Neurology 2006; 67: 2050-2052. 12. OTTAVIANI S, TINAZZI M, PASQUIN I, NOTHDURFTER W, TOMELLERI G, FINCATI E, NORDERA G, MORETTO G, FIASCHI A, SMANIA N, GIORGETTI P, ANTONINI A. Comparative analysis of visual and semi-quantitative assessment of striatal [(123)I]FP-CIT-SPET binding in Parkinson's disease. Neurol Sci 2006; 27: 397-401. 13. MARTINO D, DEFAZIO G, ABBRUZZESE G, GIRLANDA P, TINAZZI M, FABBRINI G, ANIELLO MS, AVANZINO L, COLOSIMO C, MAJORANA G, TROMPETTO C, BERARDELLI A. Head trauma in 4

primary cranial dystonias: A multi centre case control study. J Neurol Neurosurg Psychiatry 2007; 78: 260-263. 14. DEFAZIO G, MARTINO D, ABBRUZZESE G, GIRLANDA P, TINAZZI M, FABBRINI G, COLOSIMO C, ANIELLO MS, AVANZINO L, BUCCAFUSCA M, MAJORANA G, TROMPETTO C, LIVREA P, BERARDELLI A. Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: evidence from a multicentre case control study. J Neurol Neurosurg Psychiatry 2007; 78: 877-879. I 15. DELUCA C, TINAZZI M, BOVI P, RIZZUTO N, MORETTO G. Limb ataxia and proximal intracranial territory brain infarcts: clinical and topographical correlations. J Neurol Neurosurg Psychiatry 2007; 78: 832-835. 16. FIORIO M, GAMBARIN M, VALENTE EM, LIBERINI P, LOI M, COSSU G, MORETTO G, BHATIA KP, DEFAZIO G, AGLIOTI SM, FIASCHI A, TINAZZI M. Defective temporal processing of sensory stimuli in DYT1 mutation carriers: a new endophenotype of dystonia? Brain 2007; 130: 134-42. 17. SMANIA N, PAOLUCCI S, TINAZZI M, BORGHERO A, MANGANOTTI P, FIASCHI A, MORETTO G, BOVI P, GAMBARIN M. Active finger extension: a simple movement predicting recovery of arm function in patients with acute stroke. Stroke 2007; 38:1088-90. 18. FIORIO M, STANZANI C, ROTHWELL JC, BHATIA KP, MORETTO G, FIASCHI A, TINAZZI M. Defective temporal discrimination of passive movements in Parkinson's disease. Neurosci Lett 2007; 417:312-5. 19. FIORIO M, TINAZZI M, IONTA S, FIASCHI A, MORETTO G, EDWARDS MJ, BHATIA KP, AGLIOTI SM. Mental rotation of body parts and non-corporeal objects in patients with idiopathic cervical dystonia. Neuropsychologia 2007;45:2346-54. 20. TINAZZI M, DEL VESCO C, DEFAZIO G, FINCATI E, SMANIA N, MORETTO G, FIASCHI A, LE PERA D, VALERIANI M. Abnormal processing of the nociceptive input in Parkinson's disease: a study with CO2 laser evoked potentials. Pain 2008; 136: 117-24. 5

21. FIORIO M, TINAZZI M, SCONTRINI A, STANZANI C, GAMBARIN M, FIASCHI A, MORETTO G, FABBRINI G, BERARDELLI A. Tactile temporal discrimination in patients with blepharospasm. J Neurol Neurosurg Psychiatry 2008; 79: 796-798. 22. DELUCA C, TOMMASI G, MORETTO G, FIASCHI A, TINAZZI M. Focal motor seizures mimicking hemifacial spasm. Parkinsonism Relat Disord 2008; 14: 649-51. 23. MARONGIU R, FERRARIS A, IALONGO T, MICHIORRI S, SOLETI F, FERRARI F, ELIA AE, GHEZZI D, ALBANESE A, ALTAVISTA MC, ANTONINI A, BARONE P, BRUSA L, CORTELLI P, MARTINELLI P, PELLECCHIA MT, PEZZOLI G, SCAGLIONE C, STANZIONE P, TINAZZI M, ZECCHINELLI A, ZEVIANI M, CASSETTA E, GARAVAGLIA B, DALLAPICCOLA B, BENTIVOGLIO AR, VALENTE EM; ITALIAN PD STUDY GROUP. PINK 1 heterozygous rare variants: prevalence significance and phenotypic spectrum. Hum Mutat 2008; 29: 565 573. 24. FIORIO M, GAMBARIN M, DEFAZIO G, VALENTE EM, STANZANI C, MORETTO G, LOI M, SOLIVERI P, NARDOCCI N, ALBANESE A, FIASCHI A, TINAZZI M. Impaired body movement representation in DYT1 mutation carriers. Clin Neurophysiol 2008; 119: 1864-9. 25. FIORIO M, VALENTE EM, GAMBARIN M, BENTIVOGLIO AR, IALONGO T, ALBANESE A, BARONE P, PELLECCHIA MT, BRANCATI F, MORETTO G, FIASCHI A, TINAZZI M. Subclinical sensory abnormalities in unaffected PINK1 heterozygotes. J Neurol 2008; 255: 1372-7. 26. COLLOCA L, TINAZZI M, RECCHIA S, LE PERA D, FIASCHI A, BENEDETTI F, VALERIANI M. Learning potentiates neurophysiological and behavioral placebo analgesic responses. Pain 2008; 139: 306-14. 27. DEFAZIO G, BERARDELLI A, FABBRINI G, MARTINO D, FINCATI E, FIASCHI A, MORETTO G, ABBRUZZESE G, MARCHESE R, BONUCCELLI U, DEL DOTTO P, BARONE P, DE VIVO E, ALBANESE A, ANTONINI A, CANESI M, LOPIANO L, ZIBETTI M, NAPPI G, MARTIGNONI E, LAMBERTI P, TINAZZI M. Pain as a nonmotor symptom of Parkinson disease: evidence from a casecontrol study. Arch Neurol 2008; 65:1191-4. 28. TINAZZI M, OTTAVIANI S, ISAIAS IU, PASQUIN I, STEINMAYR M, VAMPINI C, PILLERI M, MORETTO G, FIASCHI A, SMANIA N, GIORGETTI P, ANTONINI A. [(123)I]FP-CIT SPET imaging in drug-induced Parkinsonism. Mov Disord 2008; 15: 1825-9. 6

29. SMANIA N, PICELLI A, GANDOLFI M, FIASCHI A, TINAZZI M. Rehabilitation of sensorimotor integration deficits in balance impairment of patients with stroke hemiparesis: a before/after pilot study. Neurol Sci 2008; 29:313-9. 30. TINAZZI M, SIMONETTO S, FRANCO L, BHATIA KP, MORETTO G, FIASCHI A, DELUCA C. Abduction finger sign: a new sign to detect unilateral functional paralysis of the upper limb. Mov Disord 2008; 15: 2415-9. 31. TINAZZI M, RECCHIA S, SIMONETTO S, DEFAZIO G, TAMBURIN S, MORETTO G, FIASCHI A, MILIUCCI R, VALERIANI M. Hyperalgesia and laser evoked potentials alterations in hemiparkinson: evidence fora an abnormal nociceptive processing. J Neurol Sci 2009; 276: 153-158. 32. TINAZZI M, ANTONINI A, BOVI T, PASQUIN I, STEINMAYR M, MORETTO G, FIASCHI A, OTTAVIANI S. Clinical and [123I]FP-CIT SPET imaging follow-up in patients with drug-induced parkinsonism. J Neurol 2009; 256: 910-915. 33. TINAZZI M, FIORIO M, FIASCHI A, ROTHWELL JC, BHATIA KP. Sensory functions in dystonia: insights from behavioral studies. Mov Disord 2009 (Review); 24: 1427-36. 34. DRAGANSKI B, SCHNEIDER SA, FIORIO M, KLÖPPEL S, GAMBARIN M, TINAZZI M, ASHBURNER J, BHATIA KP, FRACKOWIAK RS. Genotype-phenotype interactions in primary dystonias revealed by differential changes in brain structure. Neuroimage 2009 ;47:1141-7. 35. MARCEGLIA S, FIORIO M, FOFFANI G, MRAKIC-SPOSTA S, TIRITICCO M, LOCATELLI M, CAPUTO E, TINAZZI M, PRIORI A. Modulation of beta oscillations in the subthalamic area during action observation in Parkinson's disease. Neuroscience 2009 21;161: 1027-36. 36. SMANIA N, GAMBARIN M, TINAZZI M, PICELLI A, FIASCHI A, MORETTO G, BOVI P, PAOLUCCI S. Are indexes of arm recovery related to daily life autonomy in patients with stroke? Eur J Phys Rehabil Med 2009; 45: 349-54. 37. DI FONZO A, FABRIZIO E, THOMAS A, FINCATI E, MARCONI R, TINAZZI M, BREEDVELD GJ, SIMONS EJ, CHIEN HF, FERREIRA JJ, HORSTINK MW, ABBRUZZESE G, BORRONI B, COSSU G, DALLA LIBERA A, FABBRINI G, GUIDI M, DE MARI M, LOPIANO L, MARTIGNONI E, MARINI P, 7

ONOFRJ M, PADOVANI A, STOCCHI F, TONI V, SAMPAIO C, BARBOSA ER, MECO G; Italian Parkinson Genetics Network, Oostra BA, Bonifati V. GIGYF2 mutations are not a frequent cause of familial Parkinson's disease. Parkinsonism Relat Disord 2009;15:703-5. 38. SCONTRINI A, CONTE A, DEFAZIO G, FIORIO M, FABBRINI G, SUPPA A, TINAZZI M, BERARDELLI A. Somatosensory temporal discrimination in patients with primary focal dystonia. J Neurol Neurosurg Psychiatry 2009; 80: 1315-9. 39. TINAZZI M, SQUINTANI G, BERARDELLI A. Does neurophysiological testing provide the information we need to improve the clinical management of primary dystonia? Clin Neurophysiol (Review) 2009; 120: 1424-32. 40. SMANIA N, AGLIOTI SM, COSENTINO A, CAMIN M, GANDOLFI M, TINAZZI M, FIASCHI A, FACCIOLI S. A modified constraint-induced movement therapy (CIT) program improves paretic arm use and function in children with cerebral palsy. Eur J Phys Rehabil Med 2009; 45: 493-500. 41. SQUINTANI G, TINAZZI M, GAMBARIN M, BRAVI E, MORETTO G, BUTTIGLIONE M, DEFAZIO G, MARTINO D. Post-streptococcal 'complex' movement disorders: unusual concurrence of psychogenic and organic symptoms. J Neurol Sci 2010; 288: 68-71. 42. FIORIO M, CESARI P, BRESCIANI MC, TINAZZI M. Expertise with pathological actions modulates a viewer's motor system. Neuroscience 2010; 167: 691-9. 43. WALTER M, BONIN M, PULLMAN RS, VALENTE EM, LOI M, GAMBARIN M, RAYMOND D, TINAZZI M, KAMM C, GLÖCKLE N, POTHS S, GASSER T, BRESSMAN SB, KLEIN C, OZELIUS LJ, RIESS O, GRUNDMANN K. Expression profiling in peripheral blood reveals signature for penetrance in DYT1 dystonia. Neurobiol Dis 2010; 38: 192-200. 44. TINAZZI M, RECCHIA S, SIMONETTO S, TAMBURIN S, DEFAZIO G, FIASCHI A, MORETTO G, VALERIANI M. Muscular pain in Parkinson's disease and nociceptive processing assessed with CO2 laser-evoked potentials. Mov Disord 2010; 25: 213-20. 45. PICELLI A, CAMIN M, TINAZZI M, VANGELISTA A, COSENTINO A, FIASCHI A, SMANIA N. Threedimensional motion analysis of the effects of auditory cueing on gait pattern in patients with Parkinson's disease: a preliminary investigation. Neurol Sci 2010; 31: 423-430. 8

46. BOVI T, ANTONINI A, OTTAVIANI S, ANTONIOLI A, CECCHINI MP, DI FRANCESCO V, BASSETTO MA, ZAMBONI M, FIASCHI A, MORETTO G, SBARBATI A, OSCULATI F, TINAZZI M. The status of olfactory function and striatal dopaminergic system in drug-induced parkinsonism, J Neurol 2010; 257:1882-9. 47. SMANIA N, CORATO E, TINAZZI M, STANZANI C, FIASCHI A, GIRARDI P, GANDOLFI M. Effect of balance training on postural instability in patients with idiopathic Parkinson's disease. Neurorehabil Neural Repair 2010; 24:8 26-34. 48. ANTONINI A, BARONE P, CERAVOLO R, FABBRINI G, TINAZZI M, ABBRUZZESE G. Role of pramipexole in the management of Parkinson's disease. CNS Drugs 2010 ; 24: 829-41. 49. FIORIO M, ZHANG W, BRESCIANI MC, RODI G, BERTOLASI L, GAMBARIN M, TINAZZI M. Corticospinal excitability during action observation in task-specific dystonia: a transcranial magnetic stimulation study. Neuroscience 2010; 171: 117-24. 50. ZAMBITO MARSALA S, TINAZZI M, VITALIANI R, RECCHIA S, FABRIS F, MARCHINI C, FIASCHI A, MORETTO G, GIOMETTO B, MACEROLLO A, DEFAZIO G. Spontaneous pain, pain threshold, and pain tolerance in Parkinson's disease. J Neurol 2011; 258: 627-633. 51. DELUCA C, MORETTO G, DI MATTEO A, CAPPELLARI M, BASILE A, BONIFATI DM, MESIANO T, BARACCHINI C, MENEGHETTI G, MAZZUCCO S, OTTINA M, LOCHNER P, TONON A, BONOMETTI MA, DE BONI A, TURINESE E, FREDDI N, ADAMI A, PIZZINI F, DEFAZIO G, TOMELLERI G, BOVI P, FIASCHI A, TINAZZI M. Ataxia in posterior circulation stroke: Clinical-MRI correlations. J Neurol Sci 2011; 300: 39-46. 52. GARIBOTTO V, ROMITO LM, ELIA AE, SOLIVERI P, PANZACCHI A, CARPINELLI A, TINAZZI M, ALBANESE A, PERANI D. In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia. Mov Disord. 2011; 26: 852-7. 53. DI MATTEO A, FASANO A, SQUINTANI G, RICCIARDI L, BOVI T, FIASCHI A, BARONE P, TINAZZI M. Lateral trunk flexion in Parkinson's disease: EMG features disclose two different underlying pathophysiological mechanisms. J Neurol 2011; 258: 740-5. 9

54. PERROTTA A, SANDRINI G, SERRAO M, BUSCONE S, TASSORELLI C, TINAZZI M, ZANGAGLIA R, PACCHETTI C, BARTOLO M, PIERELLI F, MARTIGNONI E. Facilitated temporal summation of pain at spinal level in Parkinson's disease. Mov Disord 2011; 26: 442-8. 55. FIORIO M, WEISE D, ONAL-HARTMANN C, ZELLER D, TINAZZI M, CLASSEN J. Impairment of the rubber hand illusion in focal hand dystonia. Brain 2011;134: 1428-37. 56. BOVI T, FASANO A, JUERGENSON I, GELLERA C, CASTELLOTTI B, FONTANA E, TINAZZI M. Paroxysmal exercise-induced dyskinesia with self-limiting partial epilepsy: A novel GLUT-1 mutation with benign phenotype. Parkinsonism Relat Disord. 2011 Apr 27. 57. DEFAZIO G, ABBRUZZESE G, ANIELLO MS, BLOISE M, CRISCI C, ELEOPRA R, FABBRINI G, GIRLANDA P, LIGUORI R, MACEROLLO A, MARINELLI L, MARTINO D, MORGANTE F, SANTORO L, TINAZZI M, BERARDELLI A. Environmental risk factors and clinical phenotype in familial and sporadic primary blepharospasm. Neurology, in press. 58. MORGANTE F, TINAZZI M, SQUINTANI G, MARTINO D, DEFAZIO G, ROMITO L, ALBANESE A, DI MATTEO A, QUARTARONE A, GIRLANDA P, FIORIO M, BERARDELLI A. Abnormal tactile temporal discrimination in psychogenic dystonia. Neurology, in press. Verona, 20.07.2011 Prof. Michele Tinazzi 10