F ORMATO EUROPEO INFORMAZIONI PERSONALI. Italiana

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1 F ORMATO EUROPEO PER IL CURRICULUM VITAE INFORMAZIONI PERSONALI Nome MURRU, MARIA RITA Indirizzo Telefono Fax Nazionalità Italiana Data di nascita 14 maggio, 1956 ESPERIENZA LAVORATIVA Date (da a) 2003: Responsabile della Struttura Semplice di Neurogenetica, presso il Laboratorio Centro Sclerosi Multipla-ATSSardegna ASSL Cagliari, a oggi 1989: Vincitrice di Concorso Pubblico per titoli ed esami, per n 2 posti di Biologo collaboratore, indetto dalla ex USL n 20. In servizio presso il laboratorio della Clinica di Neuropsichiatria Infantile dell'università degli Studi di Cagliari fino al 1999; da tale data a tutt oggi presso il Laboratorio del Centro Sclerosi Multipla. Qualifica: fino al Biologo Collaboratore di ruolo, dall al Dirigente Sanitario di 1 livello presso la ex USL n 20, dall Dirigente Sanitario di 1 livello presso l Azienda USL n : Biologo Collaboratore in selezione presso il Laboratorio di Analisi dell'ospedale S.Marcellino di Muravera : Consulente esterno per la Clinica di Neuropsichiatria Infantile dell'università degli Studi di Cagliari : Incarico per l'insegnamento di "Biochimica" presso la Scuola Allieve Infermiere Professionali annessa alla Clinica Ostetrica e Ginecologica dell'università degli Studi di Cagliari. 1984: Abilitazione alla professione di Biologo : Tirocinio post-laurea presso l'istituto di Igiene dell'università degli Studi di Cagliari. Pagina 1 - Curriculum vitae di

2 Nome e indirizzo del datore di lavoro Tipo di azienda o settore Tipo di impiego Principali mansioni e responsabilità ATSSardegna Via Enrico Costa n. 57 (Piazza Fiume) Sassari (SS)1 Azienda per la tutela della salute DIRIGENTE BIOLOGO, Responsabile della Struttura Semplice di Neurogenetica Partecipa al Progetto Standardizzazione di procedimenti e metodiche laboratoristiche in neuroimmunologia-esame Liquor Ass.Italiana di Neuroimmunologia, per la definizione di linee guida, è responsabile della DIAGNOSTICA DI LABORATORIO NEL CAMPO DELLA NEUROGENETICA e dello studio dei geni che predispongono la popolazione Sarda alla Sclerosi Multipla- Fa parte del Consorzio ITALSGEN per lo studio della genetica della SLA, che collabora con il Neuromuscular Diseases Research Group, Laboratory of Neurogenetics, National Institutes of Health, di Bethesda e dell Italian Frontotemporal Dementia Network (FTD Group-SINDEM) ISTRUZIONE E FORMAZIONE Date (da a) Nome e tipo di istituto di istruzione o formazione Principali materie / abilità professionali oggetto dello studio Qualifica conseguita Livello nella classificazione nazionale (se pertinente) 1981: Laurea in Scienze Biologiche presso l'università degli studi di Cagliari. 1975: Diploma di Maturità Classica Autorizzo il trattamento dei miei dati personali ai sensi del D.lgs. 196 del 30 giugno 2003 e ss.mm.ii.. Data Cagliari, 22 marzo 2018 Firma Maria Rita Murru Pagina 2 - Curriculum vitae di

3 CAPACITÀ E COMPETENZE PERSONALI Acquisite nel corso della vita e della carriera ma non necessariamente riconosciute da certificati e diplomi ufficiali. Capacità di lettura Capacità di scrittura Capacità di espressione orale INGLESE BUONA BUONA SUFFICIENTE PRIMA LINGUA ALTRE LINGUE ITALIANO INGLESE CAPACITÀ E COMPETENZE RELAZIONALI Vivere e lavorare con altre persone, in ambiente multiculturale, occupando posti in cui la comunicazione è importante e in situazioni in cui è essenziale lavorare in squadra (ad es. cultura e sport), ecc. CAPACITÀ E COMPETENZE ORGANIZZATIVE Ad es. coordinamento e amministrazione di persone, progetti, bilanci; sul posto di lavoro, in attività di volontariato (ad es. cultura e sport), a casa, ecc. CAPACITÀ E COMPETENZE TECNICHE Con computer, attrezzature specifiche, macchinari, ecc. CAPACITÀ DI LAVORARE IN GRUPPO MATURATA IN MOLTEPLICI SITUAZIONI IN CUI ERA INDISPENSABILE LA COLLABORAZIONE TRA FIGURE DIVERSE. BUONE CAPACITÀ RELAZIONALI E ESPERIENZA PLURIENNALE NELLA GESTIONE DI GRUPPI DI COLLABORATORI COORDINAMENTO DI GRUPPI DI LAVORO NELL AMBITO DI PROGETTI ASSISTENZIALI E DI RICERCA. CAPACITÀ DI GESTIONE DELLE RISORSE, BUONE ESPERIENZE ORGANIZZATIVE, CAPACITÀ DI LAVORARE PER OBIETTIVI. ATTIVITA DI DIDATTICA E FORMAZIONE PER LAUREANDI IN BIOLOGIA E SPECIALIZZANDI IN NEUROLOGIA. BUONE CONOSCENZE INFORMATICHE DI BASE, CAPACITA DI UTILIZZO DI NUMEROSE TECNICHE IMMUNOLOGICHE E DI BIOLOGIA MOLECOLARE MANUALI ED AUTOMATIZZATE. CONOSCENZA DI PROGRAMMI SPECIFICI PER L ANALISI E L INTERPRETAZIONE DI TEST GENETICI. COAUTORE DI LAVORI DI GENETICA ED IMMUNOLOGIA PRESENTATI IN CONGRESSI NAZIONALI, INTERNAZIONALI E PUBBLICATI IN RIVISTE INTERNAZIONALI Lista Pubblicazioni 1. Lorefice L, Fenu G, Murru MR, et al. TARDBP Ala382Thr Mutation in Multiple Sclerosis: A Possible Role in Brain Atrophy Current Medical Imaging Reviews. 2018; 14(1): Cited in SCOPUS 2. Lorefice L, Murru MR, et al. Charcot-Marie-Tooth disease: genetic subtypes in the Sardinian population. Neurol Sci Jun;38(6): doi: /s x. Epub 2017 Mar 13. Erratum in: Neurol Sci Jun; 38(6):1027. PubMed [citation] PMID: Lorefice L, Murru MR, et al. Erratum to: Charcot-Marie-Tooth disease: genetic subtypes in the Sardinian population. Neurol Sci Jun;38(6):1027. doi: /s No abstract available. PubMed [citation] PMID: Stopford MJ, Higginbottom A, Hautbergue GM, Cooper-Knock J, Mulcahy PJ, De Vos KJ, Renton AE, Pliner H, Calvo A, Chio A, Traynor BJ, Azzouz M, Heath PR; ITALSGEN Consortium, NeuroX Consortium., Kirby J, Shaw PJ. C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. Hum Mol Genet Mar 15;26(6): doi: /hmg/ddx022. PubMed [citation] PMID: , PMCID: PMC Di Stefano F, Melis M, Cannas A, Borghero G, Murru MR, et al. Progressive apraxia of speech in a patient with a C9orf72 mutation. Amyotroph Lateral Scler Frontotemporal Degener Oct - Nov;17(7-8): Epub 2016 May 11. No abstract available. PubMed [citation] PMID: Borghero G, Pugliatti M, Marrosu F, Marrosu MG, Murru MR, et al. TBK1 is associated with ALS and ALS-FTD in Sardinian patients. Neurobiol Aging Jul;43:180.e1-5. doi: /j.neurobiolaging Epub 2016 Apr 9. PubMed [citation] PMID: Chiò A, Mora G, Sabatelli M, Caponnetto C, Lunetta C, Traynor BJ, Johnson JO, Nalls MA, Calvo A, Moglia C, Borghero G, Trojsi F, La Bella V, Volanti P, Simone I, Salvi F, Logullo FO, Riva N, Carrera P, Giannini F, Mandrioli Pagina 3 - Curriculum vitae di

4 J, Tanel R, Capasso M, Tremolizzo L, Battistini S, Murru MR, et al. ATNX2 is not a regulatory gene in Italian amyotrophic lateral sclerosis patients with C9ORF72 GGGGCC expansion. Neurobiol Aging Mar;39:218.e5-8. doi: /j.neurobiolaging Epub 2015 Dec 8. PubMed [citation] PMID: , PMCID: PMC Cocco E, Murgia F, Lorefice L, Barberini L, Poddighe S, Frau J, Fenu G, Coghe G, Murru MR, et al. (1)H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm Dec 24; 3(1):e185. doi: / NXI ecollection 2016 Feb. PubMed [citation] PMID: , PMCID: PMC Floris G, Borghero G, Di Stefano F, Melis R, Puddu R, Fadda L, Murru MR, et al. Phenotypic variability related to C9orf72 mutation in a large Sardinian kindred. Amyotroph Lateral Scler Frontotemporal Degener. 2016;17(3-4): doi: / Epub 2015 Nov 17. PubMed [citation] PMID: Lorefice L, Tranquilli S, Fenu G, Murru MR, et al. A genetic study of the FMR1 gene in a Sardinian multiple sclerosis population. Neurol Sci Dec;36(12): doi: / s Epub 2015 Jul 21. PubMed [citation] PMID: Cannas A, Solla P, Borghero G, Floris GL, Chio A, Mascia MM, Modugno N, Muroni A, Orofino G, Di Stefano F, Calvo A, Moglia C, Restagno G, Meloni M, Farris R, Ciaccio D, Puddu R, Vacca MI, Melis R, Murru MR, et al. C9ORF72 intermediate repeat expansion in patients affected by atypical parkinsonian syndromes or Parkinson's disease complicated by psychosis or dementia in a Sardinian population. J Neurol Nov;262(11): doi: /s Epub 2015 Aug 15. PubMed [citation] PMID: Lorefice L, Murru MR, et al. A genetic association study of two genes linked to neurodegeneration in a Sardinian multiple sclerosis population: the TARDBP Ala382Thr mutation and C9orf72 expansion. J Neurol Sci Oct 15;357(1-2): doi: /j.jns Epub 2015 Jul 26. PubMed [citation] PMID: Chiò A, Mora G, Sabatelli M, Caponnetto C, Lunetta C, Traynor BJ, Johnson JO, Nalls MA, Calvo A, Moglia C, Borghero G, Monsurrò MR, La Bella V, Volanti P, Simone I, Salvi F, Logullo FO, Nilo R, Giannini F, Mandrioli J, Tanel R, Murru MR, et al. HFE p.h63d polymorphism does not influence ALS phenotype and survival. Neurobiol Aging Oct;36(10):2906.e7-11. doi: /j.neurobiolaging Epub 2015 Jun 18. PubMed [citation] PMID: , PMCID: PMC Borghero G, Pugliatti M, Marrosu F, Marrosu MG, Murru MR, et al. ATXN2 is a modifier of phenotype in ALS patients of Sardinian ancestry. Neurobiol Aging Oct;36(10):2906.e1-5. doi: /j.neurobiolaging Epub 2015 Jun 25. PubMed [citation] PMID: , PMCID: PMC Borroni B, Turrone R, Galimberti D, Nacmias B, Alberici A, Benussi A, Caffarra P, Caltagirone C, Cappa SF, Frisoni GB, Ghidoni R, Marra C, Padovani A, Rainero I, Scarpini E, Silani V, Sorbi S, Tagliavini F, Tremolizzo L, Bruni AC; FTD Group-SINDEM. Italian Frontotemporal Dementia Network (FTD Group-SINDEM): sharing clinical and diagnostic procedures in Frontotemporal Dementia in Italy. Neurol Sci May;36(5): doi: /s Epub 2014 Dec 21. PubMed [citation] PMID: Chiò A, Mora G, Sabatelli M, Caponnetto C, Traynor BJ, Johnson JO, Nalls MA, Calvo A, Moglia C, Borghero G, Monsurrò MR, La Bella V, Volanti P, Simone I, Salvi F, Logullo FO, Nilo R, Battistini S, Mandrioli J, Tanel R, Murru MR, et al. CHCH10 mutations in an Italian cohort of familial and sporadic amyotrophic lateral sclerosis patients. Neurobiol Aging Apr; 36(4):1767.e e6. doi: /j.neurobiolaging Epub 2015 Jan 28. PubMed [citation] PMID: , PMCID: PMC Floris G, Borghero G, Cannas A, Di Stefano F, Ruiu E, Murru MR, et al. Constructional apraxia in frontotemporal dementia associated with the C9orf72 mutation: broadening the clinical and neuropsychological phenotype. Amyotroph Lateral Scler Frontotemporal Degener Mar;16(1-2):8-15. doi: / Epub 2014 Oct 6. PubMed [citation] PMID: Frau J, Cossu D, Coghe G, Lorefice L, Fenu G, Porcu G, Sardu C, Murru MR, et al. Role of interferon-beta in Mycobacterium avium subspecies paratuberculosis antibody response in Sardinian MS patients. J Neurol Sci Feb 15;349(1-2): doi: /j.jns Epub 2015 Jan 9. PubMed [citation] PMID: Floris G, Borghero G, Cannas A, Di Stefano F, Murru MR, et al. Clinical phenotypes and radiological findings in frontotemporal dementia related to TARDBP mutations. J Neurol Feb;262(2): doi: /s Epub 2014 Nov 20. Review. PubMed [citation] PMID: Borghero G, Pugliatti M, Marrosu F, Marrosu MG, Murru MR, et al. Genetic architecture of ALS in Sardinia. Neurobiol Aging Dec;35(12):2882.e e12. doi: / j.neurobiolaging Epub 2014 Jul 18. PubMed [citation] PMID: , PMCID: PMC Floris G, Di Stefano F, Pisanu C, Chillotti C, Murru MR, et al. C9ORF72 repeat expansion and bipolar disorder - is there a link? No mutation detected in a Sardinian cohort of patients with bipolar disorder. Bipolar Disord Sep;16(6): doi: /bdi Epub 2014 May 5. No abstract available. PubMed [citation] PMID: Pagina 4 - Curriculum vitae di

5 22. Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, ITALSGEN,et al. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci May; 17 (5): doi: /nn Epub 2014 Mar 30. PubMed [citation] PMID: , PMCID: PMC Chiò A, Battistini S, Calvo A, Caponnetto C, Conforti FL, Corbo M, Giannini F, Mandrioli J, Mora G, Sabatelli M; ITALSGEN Consortium, et al. Genetic counselling in ALS: facts, uncertainties and clinical suggestions. J Neurol Neurosurg Psychiatry May;85(5): doi: /jnnp Epub 2013 Jul 6. Review. PubMed [citation] PMID: Frau J, Cossu D, Coghe G, Lorefice L, Fenu G, Melis M, Paccagnini D, Sardu C, Murru MR, et al. Mycobacterium avium subsp.paratuberculosis and multiple sclerosis in Sardinian patients: epidemiology and clinical features. Mult Scler Oct;19(11): doi: / Epub 2013 Feb 25. PubMed [citation] PMID: Cannas A, Borghero G, Floris GL, Solla P, Chiò A, Traynor BJ, Calvo A, Restagno G, Majounie E, Costantino E, Piras V, Lavra L, Pani C, Orofino G, Di Stefano F, Tacconi P, Mascia MM, Muroni A, Murru MR, et al. The p.a382t TARDBP gene mutation in Sardinian patients affected by Parkinson's disease and other degenerative parkinsonisms. Neurogenetics May;14(2): doi: /s Epub 2013 Apr 2. PubMed [citation] PMID: , PMCID: PMC Floris G, Borghero G, Cannas A, Stefano FD, Murru MR, et al. Bipolar affective disorder precedingfrontotemporal dementia in a patient with C9ORF72 mutation: is there a genetic link between these two disorders? J Neurol Apr;260(4): doi: /s Epub 2013 Jan 13. No abstract available. PubMed [citation] PMID: Sabatelli M, Conforti FL, Zollino M, Mora G, Monsurrò MR, Volanti P, Marinou K, Salvi F, Corbo M, Giannini F, Battistini S, Penco S, Lunetta C, Quattrone A, Gambardella A, Logroscino G, Simone I, Bartolomei I, Pisano F, Tedeschi G, Conte A, Spataro R, La Bella V, Caponnetto C, Mancardi G, Mandich P, Sola P, Mandrioli J, Renton AE, Majounie E, Abramzon Y, Marrosu F, Marrosu MG, Murru MR et al. C9ORF72 hexanucleotide repeat expansions in the Italian sporadic ALS population. Neurobiol Aging Aug;33(8):1848.e doi: /j.neurobiolaging Epub 2012 Mar 13. PubMed [citation] PMID: , PMCID: PMC Floris G, Borghero G, Cannas A, Di Stefano F, Costantino E, Murru MR, et al. Frontotemporal dementia with psychosis, parkinsonism, visuo-spatial dysfunction, upper motor neuron involvement associated to expansion of C9ORF72: a peculiar phenotype? J Neurol Aug;259(8): doi: /s Epub 2012 Feb 10. No abstract available. PubMed [citation] PMID: , PMCID: PMC Chiò A, Restagno G, Brunetti M, Ossola I, Calvo A, Canosa A, Moglia C, Floris G, Tacconi P, Marrosu F, Marrosu MG, Murru MR, et al. ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations. JNeurol Neurosurg Psychiatry Jul;83(7): doi: /jnnp Epub 2012 May 1. PubMed [citation] PMID: , PMCID: PMC Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon- Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O; Chromosome 9-ALS/FTD Consortium; French research network on FTLD/ FTLD/ALS; ITALSGEN Consortium et al. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol Apr;11(4): doi: /s (12) Epub 2012 Mar 9. PubMed [citation] PMID: , PMCID: PMC Chiò A, Borghero G, Restagno G, Mora G, Drepper C, Traynor BJ, Sendtner M, Brunetti M, Ossola I, Calvo A, Pugliatti M, Sotgiu MA, Murru MR, et al. Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72. Brain Mar;135(Pt 3): doi: /brain/awr366. PubMed[citation] PMID: , PMCID: PMC Cocco E, Meloni A, Murru MR, et al. Vitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles. PLoS One. 2012; 7(7): e doi: /journal.pone Epub 2012 Jul 25. PubMed[citation] PMID: , PMCID: PMC Borghero G, Floris G, Cannas A, Marrosu MG, Murru MR, et al. A patient carrying a homozygous p.a382t TARDBP missense mutation shows a syndrome including ALS, extrapyramidal symptoms, and FTD. Neurobiol Aging Dec;32(12):2327.e1-5. doi: /j.neurobiolaging Epub 2011 Jul 30. PubMed [citation] PMID: , PMCID: PMC Renton AE, Majounie E, Waite A, Sim n-s ínchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; ITALSGEN Consortium et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome Pagina 5 - Curriculum vitae di

6 9p21-linked ALS-FTD. Neuron Oct 20;72(2): doi: / j.neuron Epub 2011 Sep 21. PubMed [citation] PMID: ,PMCID: PMC Chiò A, Borghero G, Pugliatti M, Ticca A, Calvo A, Moglia C, Mutani R, Brunetti M, Ossola I, Marrosu MG, Murru MR, et al. Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene. Arch Neurol May;68(5): doi: /archneurol Epub 2011 Jan 10. PubMed [citation] PMID: , PMCID: PMC Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G; ITALSGEN Consortium et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron Dec 9;68(5): doi: /j.neuron Erratum in: Neuron Jan 27;69(2):397. PubMed [citation] PMID: , PMCID: PMC Solla P, Vannelli A, Bolino A, Marrosu G, Coviello S, Murru MR,et al. Heat shock protein 27 R127W mutation:evidence of a continuum between axonal Charcot-Marie-Tooth and distal hereditary motor neuropathy. J Neurol Neurosurg Psychiatry Sep;81(9): doi: /jnnp Epub 2010 Jul 26. PubMed [citation] PMID: Solla P, Cannas A, Floris G, Murru MR, et al. Parkin Exon Rearrangements and Sequence Variants in LRRK2 Mutations Carriers: Analysis on a Possible Modifier Effect on LRRK2 Penetrance. Parkinsons Dis Aug 19;2010: doi: /2010/ PubMed [citation] PMID: , PMCID: PMC Chiò A, Calvo A, Moglia C, Restagno G, Ossola I, Brunetti M, Montuschi A, Cistaro A, Ticca A, Traynor BJ, Schymick JC, Mutani R, Marrosu MG, Murru MR, et al. Amyotrophic lateral sclerosis-frontotemporal lobar dementia in 3 families with p.ala382thr TARDBP mutations. Arch Neurol Aug;67(8): doi: /archneurol PubMed [citation] PMID: , PMCID: PMC Floris G, Cannas A, Solla P, Murru MR, et al. Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients. Parkinsonism Relat Disord May;15(4): doi: /j.parkreldis Epub 2008 Sep 20. PubMed [citation] PMID: Murru MR, et al. A novel Cx32 mutation causes X-linked Charcot-Marie-Tooth disease with brainstem involvement and brain magnetic resonance spectroscopy abnormalities. Neurol Sci Apr;27(1): PubMed [citation] PMID: Marrosu MG, Cocco E, Costa G, Murru MR, et al. Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population. J Neurol Feb; 253(2): Epub 2005 Aug 17. PubMed [citation] PMID: Cocco E, Sotgiu A, Costa G, Murru MR, et al. HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS. Neurology Feb 8;64(3): PubMed [citation] PMID: Marrosu MG, Sardu C, Cocco E, Costa G, Murru MR, et al. Bias in parental transmission of the HLA-DR3 allele in Sardinian multiple sclerosis. Neurology Sep 28;63(6): PubMed [citation] PMID: Cocco E, Murru MR, et al.ptprc (CD45) C77G mutation does not contribute to multiple sclerosissusceptibility in Sardinian patients. J Neurol Sep;251(9): PubMed[citation] PMID: Cocco E, Mancosu C, Fadda E, Murru MR, et al. Lack of evidence for a role of the myelin basic protein gene in multiple sclerosis susceptibility in Sardinian patients. J Neurol Nov;249(11): PubMed[citation] PMID: Marrosu MG, Murru R, Murru MR, et al. Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia. Hum Mol Genet Dec 1; 10(25): PubMed [citation] PMID: D'Alfonso S, Nisticò L, Bocchio D, Bomprezzi R, Marrosu MG, Murru MR, et al. An attempt of identifying MSassociated loci as a follow-up of a genomic linkage study in the Italian population. J Neurovirol May;6 Suppl 2:S PubMed [citation] PMID: Marrosu MG, Murru MR, et al. DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population. Hum Mol Genet Aug;7(8): PubMed [citation] PMID: Marrosu MG, Murru MR, et al. Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3and-DR4 alleles. Am J Hum Genet Aug;61(2): No abstract available. PubMed [citation] PMID: , PMCID: PMC Murru MR, et al.. A new allelic variant of HLA-DRB1*1101 (DRB1*11013) segregating in a Sardinian family. Tissue Antigens Nov;48(5): No abstract available. PubMed [citation] PMID: Pagina 6 - Curriculum vitae di

7 52. Haegert DG, Muntoni F, Murru MR, et al. HLA-DQA1 and-dqb1 associations with multiple sclerosis in Sardinia and French Canada: evidence for immunogenetically distinct patient groups. Neurology Mar;43(3 Pt 1): PubMed [citation] PMID: Marrosu MG, Muntoni F, Murru MR, et al. Role of predisposing and protective HLA-DQA and HLA-DQB alleles in Sardinian multiple sclerosis. Arch Neurol Mar;50(3): PubMed [citation] PMID: Marrosu MG, Muntoni F, Murru MR, et al. HLA-DQB1 genotype in Sardinian multiple sclerosis:evidence for a key role of DQB1 *0201 and *0302 alleles. Neurology Apr;42(4): PubMed [citation] PMID: Muntoni F, Lampis R, Frau F, Argiolas L, Murru MR, et al. A PvuII RFLP at D6S114E locus in the HLA region (RING4 locus). Nucleic Acids Res Dec 25;19(24):6974. No abstract available. PubMed [citation] PMID: , PMCID: PMC Muntoni F, Murru MR, et al. Different HLA DR2-DQw1 haplotypes in Sardinian and northern Italian populations: implications for multiple sclerosis susceptibility. Tissue Antigens Jul;38(1):34-6. No abstract available. PubMed [citation] PMID: Marrosu MG, Muntoni F, Murru MR, et al. Sardinian multiple sclerosis is associated with HLA-DR4: a serologic and molecular analysis. Neurology Nov;38(11): PubMed [citation] PMID: Ennas MG, Laconi S, Dess ş S, Milia G, Murru MR, et al. Influence of dehydroepiandrosterone on G-6-PD activity and 3H-thymidine uptake of human lymphocytes in vitro. Toxicol Pathol. 1987;15(2): PubMed [citation] PMID: Ennas MG, Murru MR, et al. Lymphocyte subsets in human adenoids and tonsils. Rosette formation, alphanaphthyl acetate esterase cytochemistry, monoclonal antibodies and peanut lectin reactivity. Immunol Lett. 1984;8(1):1-9. PubMed [citation] PMID: Manconi PE, Ennas MG, Murru MR, et al. Epithelial-like cells containing lymphocytes (nurse cells) in human adenoids and tonsils. Thymus.1984;6(6): PubMed [citation] PMID: Marrosu MG, Ennas MG, Murru MR, et al. Surface markers on lymphocytes from human cerebrospinal fluid. Identification by monoclonal antibodies. J Neuroimmunol Dec;5(3): PubMed [citation] PMID: Marrosu MG, Cianchetti C, Tondi M, Ennas MG, Marrosu G, Murru MR,et al. Lymphocyte subpopulations in blood and cerebrospinal fluid from patients with subacute sclerosing panencephalitis. Acta Neurol Scand Jan;67(1): PubMed [citation] PMID: Pagina 7 - Curriculum vitae di