Francesco Benedetti, M.D. Curriculum Vitae

Transcript

1 Francesco Benedetti, M.D. Curriculum Vitae February 7, 2012 Contacts: Istituto Scientifico Universitario Ospedale San Raffaele Department of Clinical Neurosciences San Raffaele Turro via Stamira D'Ancona Milano Italy Phone: Fax: benedetti.francesco@hsr.it 1

2 Personal Informations Born: Citizenship: March 3, 1966 in Modena, Italy Italian Education, licensure and certification Certifications: Residency: Graduate: Italian medical licensure Diplomate in Psychiatry Diplomate in Clinical Psychology Clinical Psychology, University of Milan, Italy Psychiatry, University Vita-Salute San Raffaele, Milan, Italy School of Medicine (1991), University of Modena, Italy. Current appointments - Head Clinical Research Group Psychiatry and Clinical Neurosciences Division of Neuroscience - Ospedale San Raffaele, Milano (2009) - Area coordinator Department of Clinical Neurosciences - Ospedale San Raffaele (2007) - Contract Professor of Psychiatry, School of Medicine (degree in Medicine, residency in Psychiatry), University Vita-Salute San Raffaele, Milano (2002) Membership in scientific institutions - Collegium Internationale Neuro-Psychopharmacologicum (CINP), Education Committee - European College of Neuropsychopharmacology (ECNP) - International Society for Affective Disorders - Committee on Chronotherapeutics in Affective Disorders ( - Center for Environmental Therapeutics ( scientific board - Operating Committee of the Centro di Eccellenza Risonanza Magnetica ad Alto Campo di Milano (C.E.R.M.A.C.) (Center of Excellence for High-Field Magnetic Resonance Imaging), funded by the Italian Ministry of Health and the Italian Ministry of University and Scientific Research Francesco Benedetti (total cites 2759, h-index = 31) authored scientific publications since 1996 on peer-reviewed international journals. During his career he combined his research activities with clinical work, mainly in the field of mood disorders, with university teaching appointments, and with coordination and leadership of research units. His main research interests are within the field of translational and reverse-translational research in psychiatry (see list of publications), and include chronobiology and chronotherapeutics of mood disorders (A), psychiatric genetics and clock genes (B), brain imaging and neural correlates of psychiatric diseases and therapeutics (C). Other areas of interest (D) include clinical neuropsychology and animal models of psychiatric diseases. 2

3 Training and Experiences Pre-doctoral research fellow at the Institute of Human Physiology, State University of Modena (Prof. E.A. Moja, Prof. L.F. Agnati) Post-doctoral research fellow at the Chair of Medical Psychology, Institute of Psychology, State University of Milan (Prof. E.A. Moja) Italian Army (military obligation), Medical Lieutenant Post-doctoral research fellow at the Chair of Psychiatry, Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, State University of Milan (Prof. E. Smeraldi) Staff Psychiatrist at the Mood Disorder Unit, Psychiatric Branch, Istituto Scientifico Ospedale San Raffaele 2002 Area Coordinator (Scientific research activities) at the Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele Head Clinical Research Group Psychiatry and Clinical Neurosciences Division of Neuroscience - Istituto Scientifico Ospedale San Raffaele. With a matrix structure, this research group includes people and structures affiliated to (1) the Department of Clinical Neurosciences of the Ospedale San Raffaele, including the units of psychiatry (7 wards, 120 beds, 2 day-hospital services, two outpatient services), sleep medicine (10 beds), and clinical psychology; (2) the Chairs of Psychiatry and Clinical Psychology of the Università Vita-Salute San Raffaele; and (3) the research units of Psychiatry and Clinical Psychobiology, Sleep Medicine, and Clinical Psychology of the Division of Neuroscience of the San Raffaele Scientific Institute. Being the Head of the Research Group, F.B. personally directs the unit of Psychiatry and Clinical Psychobiology, and coordinates the other group leaders activities. Research activities focus at the interface between neuroscience and behavioral disorders, with the aim of increasing scientific knowledge and developing effective diagnosis and treatment options in the broad field of Psychiatry and Clinical Neurosciences. Areas of expertise encompass clinical psychobiology, in vivo imaging, genetics, pharmacology, neuropsychology, neurophysiology, and clinical research, to face the questions of modern clinical psychiatry, neurology, and clinical psychology. Facilities include a in-house psychiatric genetics laboratory (since 1990), access to a 3.0 T MRI scanner in a dedicated research center (C.E.R.M.A.C., 2005), and a molecular biology laboratory for animal research (2010). Clinical and research activities began in 1988, and has increased over time. A simple Medline search (Jan 09) restricted to the previous 10 years allows a rough quantitation of recent scientific products by giving 226 papers in the field of psychiatry; 106 in the field of sleep medicine; and 25 in the field of clinical psychology. In the field of psychiatry the outstanding achievements have been matter for independent investigations by lay media in the years 2004 and 2006: the evaluation of the total Impact Factor ranked the psychiatric branch of the group at the 1st place among all psychiatric research structures in Italy (our I.F vs 60.1 second place in 2004), and at the third place in western Europe (2006, I.F in the field of mood disorders). 3

4 Teaching Appointments - University Assistant Professor Chair of Psychiatry - University of Milano, Italy Assistant Professor Chair of Psychiatry University Vita-Salute San Raffaele, Milano Contract professor of General Psychopathology, School of Psychology, Università Vita-Salute San Raffaele present Contract professor of Psychiatry, School of Medicine, Università Vita-Salute San Raffaele, Milano. Course on Ethics and psychiatry of suicide, required for first year residents, and elective for fourth-sixth year students in medicine and third-fifth year students in clinical psychology. Teaching Appointments - Others Coordinator of teaching activities and primary lecturer - European Social Fund, Italian Ministry of Employment, Regione Lombardia Advanced Post-doctoral Educational Program - Course Project 3 D4 n.34026; and CME Program of the Italian Ministry of Health, Course Projects n and Non-pharmacological treatment of major depression. (2002). Coordinator of teaching activities and primary lecturer - European Social Fund, Italian Ministry of Employment, Regione Lombardia Advanced Pre-doctoral Educational Program - Course Project n Psychometric techniques in clinical practice. (2003) Coordinator of scientific activities and lecturer - European Social Fund, Italian Ministry of Employment, Regione Lombardia Advanced Post-doctoral Educational Program; and CME Program of the Italian Ministry of Health, Course Project n Sleep Deprivation and Chronobiology of Depression, Milano (2003). Boards, Reviewer, Scientific advisor Co-editor of Neurology, Psychiatry and Brain Research (prev. Zentralblatt fur die gesamte Neurologie und Psychiatrie), Elsevier Science Publishing ( ) Editorial board: Rivista di Psichiatria ( ) The Open Psychiatry Journal ( The Open Magnetic Resonanace Journal ( Reviewer : University of California Irvine; Swiss National Science Foundation; American Journal of Medical Genetics; American Journal of Psychiatry; Annals of Medicine; Archives of General Psychiatry; 4

5 Arthritis Research & Therapy; Biological Psychiatry; BioMedCentral Psychiatry; BioMedCentral Neuroscience; Bipolar Disorders; Chronobiology International; Current Psychiatry Reviews; Depression and Anxiety; European Child & Adolescent Psychiatry; European Neuropsychopharmacology; Future Medicine Therapy; International Journal of Neuropsychopharmacology; Journal of Affective Disorders; Journal of Biological Rhythms; Journal of Circadian Rhythms; Journal of Clinical Psychiatry; Journal of Clinical Psychopharmacology; Journal of Psychiatric Research; Journal of Psychopharmacology; Journal of Sleep Research; Molecular Psychiatry; NeuroImage Neuropsychologia; Neuropsychopharmacology; Neuroradiology; Neuroscience and Biobehavioral Reviews; Neuroscience Letters; Nutritional Neuroscience; Pharmacopsychiatry; Progress in Neuropsychopharmacology and Biological Psychiatry; Psychiatry Investigation; Psychiatry Research; Schizophrenia Research; The Lancet; The Pharmacogenomics Journal; The World Journal of Biological Psychiatry. Grants European Union FP7 grant (Health From Mood disorders to experimental models) MOODINFLAME: Early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system (P.I.) Italian Ministry of University and Scientific Research, PRIN project n Genetic and neural imaging aspects of antidepressant response (co-investigator) Unrestricted research grant from Janssen-Cilag S.p.A. (Italy) to Vita-Salute San Raffaele University-C.E.R.M.A.C. for the acquisition and maintenance of a 3.0 T magnetic resonance imaging scanner (co-investigator) European Union and Italian Ministry of Employment - Educational grant for project n Psychometric techniques in clinical practice. (Coordinator) European Union and Italian Ministry of Employment - Educational grant for projects n and Non-pharmacological treatment of major depression. (Coordinator) 5

6 List of Publications (thematic and chronological order, earliest to latest) Journal Articles, peer reviewed Full papers A. Chronobiology and chronotherapeutics of mood disorders 1. Benedetti F, Barbini B, Colombo C, Campori E, Smeraldi E (1996) Infradian mood fluctuations during a major depressive episode. Journal of Affective Disorders, 41(2): Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E (1996) Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation. Psychiatry Research, 65(3): Benedetti F, Barbini B, Lucca A, Campori E, Colombo C, Smeraldi E (1997) Sleep deprivation hastens the antidepressant action of fluoxetine. European Archives of Psychiatry and Clinical Neurosciences, 247(2): Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E (1998) Patterns of mood variation during antidepressant treatment. Journal of Affective Disorders, 49(2): Barbini B, Colombo C, Benedetti F, Campori E, Bellodi L, Smeraldi E. (1998) The unipolar/bipolar dichothomy and the response to sleep deprivation. Psychiatry Research, 79(1): Smeraldi E, Benedetti F, Campori E. (1998) Sustaining the effect of sleep deprivation [letter]. American Journal of Psychiatry, 155(8): Barbini B, Benedetti F, Colombo C, Guglielmo E, Campori E, Smeraldi E. (1998) Perceived mood and biological rhythms in depression. European Archives of Psychiatry and Clinical Neurosciences, 248(3): Benedetti F, Zanardi R, Colombo C, Smeraldi E. (1999) Worsening of delusional depression after sleep deprivation: case reports. Journal of Psychiatric Research, 33(1): Smeraldi E, Benedetti F, Barbini B, Campori C, Colombo C (1999) Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression: a placebocontrolled trial. Neuropsychopharmacology, 20(4): Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E. (1999) Ongoing lithium treatment prevents relapse after sleep deprivation. Journal of Clinical Psychopharmacology, 19(3): Colombo C, Benedetti F, Barbini B, Campori E, Smeraldi E. (1999) Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression. Psychiatry Research, 86(3):

7 12. Colombo C, Lucca A, Benedetti F, Barbini B, Campori E, Smeraldi E (2000) Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry Research, 95(1): Benedetti F, Colombo C, Barbini B, Campori E, Smeraldi E (2001) Morning sunlight reduces lenght of hospitalization for bipolar depression. Journal of Affective Disorders, 62(3): Benedetti F, Campori E, Barbini B, Cigala Fulgosi M, Colombo C (2001) Dopaminergic augmentation of sleep deprivation effects in bipolar depression. Psychiatry Research, 104(3): Benedetti F, Barbini B, Campori E, Cigala Fulgosi M, Pontiggia A., Colombo C (2001) Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings sustaining the internal coincidence model? Journal of Psychiatric Research, 35(6): Benedetti F, Lucca A, Brambilla F, Colombo C, Smeraldi E (2002) Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 26: Benedetti F, Colombo C, Serretti A, Pontiggia A, Bernasconi A, Florita M, Smeraldi E (2003) Morning light treatment hastens the antidepressant effect of citalopram: a placebo controlled trial. Journal of Clinical Psychiatry, 64(6): Benedetti F, Pontiggia A, Bernasconi A, Colombo C, Florita M, Smeraldi E (2004) Lormetazepam in depressive insomnia: new evidences for phase-response effects of benzodiazepines. International Clinical Neuropsychopharmacology, 19(5): Wirz-Justice A, Benedetti F, Berger M, Lam RW, Martiny K, Terman M, Wu JC (2005) Chronotherapeutics (light and wake therapy) in affective disorders. Psychological Medicine, 35(7): Barbini B, Benedetti F, Colombo C, Dotoli D, Bernasconi A, Cigala Fulgosi M, Florita M, Smeraldi E (2005) Dark therapy for mania: a pilot study. Bipolar Disorders, 7(1): Benedetti F, Barbini B, Florita M, Cigala Fulgosi M, Campori E, Colombo C, Smeraldi E (2005) Rapid improvement in information processing after sleep deprivation and sleep phase-advance in bipolar depression. Clinical Psychiatry, 2(3): Benedetti F, Barbini B, Cigala Fulgosi M, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (2005) Long term effects of combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression. Journal of Clinical Psychiatry, 66(12): Benedetti F, Barbini B, Colombo C, Smeraldi E (2007) Chronotherapeutics in a psychiatric ward. Sleep Medicine Reviews, 11(6):

8 24. Benedetti F, Dallaspezia S, Cigala Fulgosi M, Barbini B, Colombo C, Smeraldi E (2007) Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression. Chronobiology International, 24(5): Benedetti F, Smeraldi E (2007) Comment on the potential role of ghrelin in the mechanism of sleep deprivation therapy for depression. [letter] Sleep Medicine Reviews, 11(6): Benedetti F, Fresi F, Maccioni P, Smeraldi E (2008) Behavioural sensitization to repeated sleep deprivation in a mice model of mania. Behavioural Brain Research, 187(2): Benedetti F, Smeraldi E (2009) Neuroimaging and genetics of antidepressant response to sleep deprivation: implications for drug development. Current Pharmaceutical Design, 15(22): Dallaspezia S, Benedetti F (2009) Melatonin, circadian rhythms, and the clock genes in bipolar disorder. Current Psychiatry Reports, 11(6): Dallaspezia S, Benedetti F (2011) Chronobiological therapy for mood disorders. Expert Reviews of Neurotherapeutics, 11(7): Benedetti F, Colombo C (2011) The use of sleep deprivation in mood disorders. Neuropsychobiology, 64: Wirz-Justice A, Bader A, Frisch U, Stieglitz RD, Alder J, Bitzer J, Hösli I, Jazbec S, Benedetti F, Terman M, Wisner K, Riecher-Rössler A. A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression. Journal of Clinical Psychiatry, 72(7): B. Psychiatric genetics 32. Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Catalano M (1998) Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Molecular Psychiatry, 3(6): Benedetti F, Serretti A, Colombo C, Campori E, Barbini B, Di Bella D, Smeraldi E. (1999) Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. American Journal of Psychiatry, 156(9): Serretti A, Benedetti F, Colombo C, Lilli R, Lorenzi C, Smeraldi E (1999) Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation. Psychiatry Research, 89(2):

9 35. Zanardi R, Benedetti F, Di Bella D, Catalano M, Smeraldi E (2000) Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Journal of Clinical Psychopharmacology, 20(1): Benedetti F, Serretti A, Colombo C, Campori E, Barbini B, Di Bella D, Smeraldi E (2000) Some ado for a polymorphism [letter; reply]. American Journal of Psychiatry, 157(11): Schumann G, Benedetti F, Voderholzer U, Kammerer N, Hemmeter U, Travers HW, Fiebich B, Holsboer-Trachsler E, Berger M, Seifritz E, Ebert D (2001) Antidepressive response to sleep deprivation in unipolar depression is not associated with dopamine D3 receptor genotype. Neuropsychobiology, 43(3): Smeraldi E, Benedetti F, Zanardi R (2002) Serotonin transporter promoter genotype and illness recurrence in mood disorders. European Neuropsychopharmacology, 12(1): Benedetti F, Serretti A, Colombo C, Lilli R, Lorenzi C, Smeraldi E (2003) Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression. Psychiatry Research, 118(3): Benedetti F, Colombo C, Serretti A, Lorenzi C, Pontiggia A, Barbini B, Smeraldi E (2003) Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biological Psychiatry, 54(7): Serretti A, Benedetti F, Mandelli L, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2003) Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. American Journal of Medical Genetics, 121B(1): Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E. (2004) A glycogen synthase kinase 3-β promoter gene SNP is associated with age at onset and response to total sleep deprivation in bipolar depression. Neuroscience Letters, 368(2) Cavallaro R, Lattuada E, Benedetti F, Lorenzi C, Smeraldi E (2004) Genetic dissection of drug side effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness. Neuroscience Letters, 367(2) Benedetti F, Serretti A, Pontiggia A, Bernasconi A, Lorenzi C, Colombo C, Smeraldi E (2005) Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-β -50 T/C SNP. Neuroscience Letters, 376(1): Serretti A, Cusin C, Benedetti F, Mandelli L, Pirovano A, Zanardi R, Colombo C, Smeraldi E (2005) Insomnia improvement during antidepressant treatment and CLOCK gene polymorphism. American Journal of Medical Genetics, B, 137(1): Benedetti F, Serretti A, Colombo C, Barbini B, Lorenzi C, Campori E, Smeraldi E (2003) Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. American Journal of Medical Genetics, 123B(1):

10 47. Benedetti F, Bernasconi A, Lorenzi C, Pontiggia A, Serretti A, Colombo C, Smeraldi E (2004) Glycogen synthase kinase 3-b influences age at onset of bipolar disorder. Neuroscience Letters, 355(1-2): Serretti A, Benedetti F, Zanardi R, Smeraldi E (2005) The influence of SERTPR and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29: Benedetti F, Dallaspezia S, Cigala Fulgosi M, Lorenzi C, Serretti A, Barbini B, Colombo C, Smeraldi E (2007) Actimetric evidence that CLOCK 3111 T/C SNP influences depressive insomnia and activity patterns in bipolar depression. American Journal of Medical Genetics - B - Neuropsychiatric Genetics 144B(5): Serretti A, Benedetti F, Mandelli L, Calati R, Caneva B, Lorenzi C, Fontana V, Colombo C, Smeraldi E (2008) Association between GSK-3β 50T/C polymorphism and psychotic symptoms in mood disorders. Psychiatry Research, 158(2): Artioli P, Lorenzi C, Pirovano A, Serretti A, Benedetti F, Catalano M, Smeraldi E (2008) How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes. European Neuropsychopharmacology, 17(9): Benedetti F, Barbini B, Bernasconi A, Cigala Fulgosi M, Campori E, Colombo C, Dallaspezia S, Lorenzi C, Pontiggia A, Radaelli D, Smeraldi E (2008) Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation. Journal of Clinical Psychopharmacology, 28(2): Benedetti F, Barbini B, Bernasconi A, Cigala Fulgosi M, Colombo C, Gavinelli C, Marino E, Pirovano A, Radaelli D, Smeraldi E (2008) Serotonin 5-HT 2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32: Benedetti F, Dallaspezia S, Colombo C, Pirovano A, Marino E, Smeraldi E (2009) A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neuroscience Letters, 445(2): Benedetti F, Colombo C, Pirovano A, Marino E, Smeraldi E (2009) The catechol-omethyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting. Psychopharmacology, 203(1): Benedetti F, Barbini B, Bernasconi A, Cigala Fulgosi M, Dallaspezia S, Gavinelli C, Locatelli C, Lorenzi C, Pirovano A, Radaelli D, Smeraldi E, Colombo C (2010) Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-omethyltransferase Val(108/158)Met polymorphism. Journal of Affective Disorders, 121(1-2):

11 57. Benedetti F, Dallaspezia S, Colombo C Lorenzi C, Pirovano A, Smeraldi E (2010) Effect of catechol-o-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine. European Psychiatry, 25(8): Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E (2010) Association between catechol-o-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. Journal of Affective Disorders, 125: Dallaspezia S, Benedetti F, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2011) Circadian clock gene Per3 variants influence the post-partum onset of bipolar disorder. European Psychiatry, 26(3): Benedetti F,Radaelli D, Poletti S, Dallaspezia S, Locatelli C, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2011) Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors before bipolar depression. Journal of Affective Disorders, 132: Benedetti F, Dallaspezia S, Locatelli C, Radaelli D, Poletti S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2011) Recurrence of bipolar mania is associated with catechol-omethyltransferase Val(108/158)Met polymorphism. Journal of Affective Disorders, 132: Benedetti F, Dallaspezia S, Lorenzi C, Pirovano A, Radaelli D, Locatelli C, Poletti S, Colombo C, Smeraldi E Gene-gene interaction of glycogen synthase kinase 3-B and serotonin transporter on human antidepressant response to sleep deprivation. Journal of Affective Disorders, in press. DOI information: /j.jad C. Brain imaging and neural correlates of psychiatric diseases 63. Benedetti F, Bernasconi A, Pontiggia A (2006) Depression and neurological disorders. Current Opinions in Psychiatry, 19: Benedetti F, Bernasconi A, Blasi V, Cadioli M, Colombo C, Falini A, Lorenzi C, Radaelli D, Scotti G, Smeraldi E (2007) Neural and genetic correlates of antidepressant response to sleep deprivation: a fmri study of moral valence decision in bipolar depression. Archives of General Psychiatry, 64: Benedetti F, Radaelli D, Bernasconi A, Dallaspezia S, Falini A, Lorenzi C, Scotti G, Colombo C, Smeraldi E (2008) Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in patients affected by bipolar depression. Genes Brain and Behaviour, 7(1): Radaelli D, Bernasconi A, Benedetti F (2008) Advanced MRI techniques in: Psychiatric diseases. Neurological Sciences, 29 Suppl 3:

12 67. Benedetti F, Calabrese G, Bernasconi A, Cadioli M, Colombo C, Dallaspezia S, Falini A, Radaelli D, Scotti G, Smeraldi E (2009) Spectroscopic correlate of antidepressant response to sleep deprivation and light therapy: a 3.0 T study of bipolar depression. Psychiatry Research Neuroimaging, 173(3): Benedetti F, Radaelli D, Bernasconi A, Dallaspezia S, Colombo C, Smeraldi E (2009) Changes in medial prefrontal cortex neural responses parallel successful antidepressant combination of venlafaxine and light therapy. Archives Italiennes de Biologie, 147: Fusar-Poli P, Placentino A, Carletti F, Landi P, Allen P, Surguladze S, Benedetti F, Abbamonte M, Gasparotti R, Barale F, Perez J, McGuire P, Politi PF (2009) Functional atlas of emotional faces processing: a voxel based (ALE) meta-analysis of 105 fmri studies. Journal of Psychiatry and Neuroscience, 34(6): Benedetti F, Bernasconi A, Bosia M, Cavallaro R, Dallaspezia S, Falini A, Poletti S, Radaelli D, Riccaboni R, Scotti G, Smeraldi E (2009) Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia. Schizophrenia Research, 114(1-3): Benedetti F, Poletti S, Radaelli D, Bernasconi A, Cavallaro R, Falini A, Dallaspezia S, Lorenzi C, Pirovano A, Locatelli C, Scotti G, Smeraldi E (2010) Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-β activity. Genes Brain and Behavior, 9(4): Benedetti F, Radaelli D, Poletti S, Falini A, Cavallaro R, Dallaspezia S, Riccaboni R, Scotti G, Smeraldi E (2011) Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences. Psychological Medicine, 41(3): Benedetti F, Ping-Hong Yeh, Bellani M, Radaelli D, Nicoletti MA, Poletti S, Falini A, Dallaspezia S, Colombo C, Scotti G, Smeraldi E, Soares JC, Brambilla P (2011) Disruption of white matter integrity in bipolar depression as a possible structural marker of illness. Biological Psychiatry, 69(4): Benedetti F, Absinta M, Rocca M, Radaelli D, Poletti S, Bernasconi A, Dallaspezia S, Pagani E, Falini A, Colombo C, Comi G, Smeraldi E (2011) Tract-specific white matter structural disruption in patients with bipolar disorder. Bipolar Disorders, 13(4): Benedetti F,Radaelli D, Poletti S, Locatelli C, Falini A, Colombo C, Smeraldi E. Opposite effects of suicidality and lithium on grey matter volumes in bipolar depression. Journal of Affective Disorders, 135 (1-3): Radaelli D, Poletti S, Dallaspezia S, Colombo C, Smeraldi E, Benedetti F (2012) Neural responses to emotional stimuli in comorbid Borderline Personality Disorder and Bipolar Depression. Psychiatry Research- Neuroimaging, in press 77. Benedetti F, Poletti S, Radaelli D, Pozzi E, Giacosa C, Ruffini C, Falini A, Smeraldi E (2012) Caudate grey matter volume in obsessive-compulsive disorder is influenced by adverse 12

13 childhood experiences and ongoing drug treatment. Journal of Clinical Psychopharmacology, in press D. Others 78. Moja EA, Rocchi E, Benedetti F, Paolillo F, Casalgrandi G, Ponz de Leon M (1991) Decrease in plasma tryptophan after a tryptophan-free amino acid solution. A comparison between cirrhotic and control subjects. Life Sciences, 48: Benedetti F, Moja EA (1993) Failure of a tryptophan-free amino acid mixture to modify sexual behavior in the female rat. Physiology and Behavior, 53: Moja EA, Benedetti F (1996) Sexual behavior in male and female rats after tryptophan-free diet. Advances in Experimental Medicine and Biology, 398: Moja EA, Lucini V, Benedetti F, Lucca A (1996) Decrease in plasma phenylalanine and tyrosine after phenylalanine-tyrosine free amino acid solutions in man. Life Sciences, 58(26): Barbini B, Scherillo P, Benedetti F, Crespi G, Colombo C, Smeraldi E. (1997) Response to clozapine in acute mania is more rapid than that of chlorpromazine. International Clinical Psychopharmacology, 12 (2): Benedetti F, Sforzini L, Colombo C, Maffei C, Smeraldi E. (1998) Low-dose clozapine in acute and continuation treatment of severe borderline personality disorder. Journal of Clinical Psychiatry, 59(3): Benedetti F, Cavallaro R, Smeraldi E (1999) Olanzapine-induced neutropenia after clozapine-induced neutropenia. The Lancet, 354(9178): Benedetti F, Campori E, Colombo C, Smeraldi E (2004) Fluvoxamine treatment of major depression associated with multiple sclerosis. Journal of Neuropsychiatry and Clinical Neurosciences, 16(3): Benedetti F, Barbini B, Cigala Fulgosi M, Pontiggia A, Colombo C, Smeraldi E (2005) Cognitive assessment of depression: a new test for mood disorders. Clinical Psychiatry, 2(3): Florita M, Bernasconi A, Santoro A, Pontiggia A, Benedetti F (2005) Specificity of depressive core in cardiosurgery department. Clinical Psychiatry, 2(3): Santoro A, Florita M, Rossini D, Benedetti F, Lucca A (2005) The processing of emotional stimuli in subjects with a major depressive episode treated with rtms. Clinical Psychiatry, 2(3):

14 89. Benedetti F, Anselmetti S, Florita M, Radaelli D, Cavallaro R, Colombo C, Smeraldi E (2005) Reality monitoring and paranoia in remitted delusional depression. Clinical Psychiatry, 2(3): Zanardi R, Barbini B, Rossini D, Bernasconi A, Fregni F, Padberg F, Rossi S, Wirz-Justice A, Terman M, Martiny K, Bersani G, Hariri AR, Pezawas L, Roiser JP, Bertolino A, Calabrese G, Magri L, Benedetti F, Pontiggia A, Malaguti A, Smeraldi E, Colombo C (2008) New perspectives on techniques for the clinical psychiatrist: Brain stimulation, chronobiology and psychiatric brain imaging. Psychiatry and Clinical Neurosciences, 62(6): Ruffini C, Locatelli M, Lucca A, Benedetti F, Insacco C, Smeraldi E (2009) Augmentation effect of repetitive transcranial magnetic stimulation over the orbitofrontal cortex in drugresistant obsessive-compulsive disorder patients: a controlled investigation. Primary care companion to the Journal of Clinical Psychiatry, 11(5): Books and Book Chapters 92. Moja EA, Benedetti F (1992) Somministrazione di miscele di aminoacidi prive di triptofano: una rassegna degli effetti biochimici e comportamentali. In: Nutrizione e cervello, a cura di LF Agnati, EA Moja e G Tettamanti; pp Pithagora Press, Milano. 93. Benedetti F, Colombo C, Sforzini L, Maffei C, Smeraldi E. (1999) New drugs in the treatment of borderline personality disorder. In: Treatment of personality disorders. A cura di J Derksen, C Maffei e H Grohen. Kluwer Academic / Plenum Publishers, New York, pag Colombo C, Benedetti F, Barbini B, Smeraldi E (2000) Uso delle benzodiazepine nei disturbi dell umore. In: Le benzodiazepine: dalla molecola alla pratica clinica. A cura di G Biggio. Springer-Verlag Italia, Milano, pp Benedetti F (2005) Quattro motivi per morire: il suicidio come comportamento umano. Airon, Milano. [Four reasons to die: suicide as a human behaviour] 96. Wirz-Justice A, Benedetti F, Terman M (2009) Chronotherapeutics for affective disorders. A clinician s manual for light and wake therapy. Karger, Basel. ISBN-13: e- ISBN: Dallaspezia S, Benedetti F. (2010) Genetics of circadian rhythms in relation to mental illness. In: Sleep and Mental Illness, M Kramer and SR Pandi Perumal eds. Cambridge University Press. ISBN-13: Benedetti F (2010) Brain imaging funzionale della depressione. In: I disturbi dell'umore clinica e terapia, a cura di E. Smeraldi. Sintesi Infomedica, Milano. ISBN: ISBN-13:

15 99. Benedetti F (2011) Sommeil et rythmes circadiens dans le troubles bipolaires à début précoce. In: M. Leboyer (ed.) Âge et mode de début des maladies psychiatriques : Perspective cliniques, étiologiques et thérapeutiques. Elsevier-Masson. ISBN: p Journal Articles, italian journals 100. Antonietti A, Benedetti F, Caselgrandi E, Moja EA (1991) Il consumo etilico spontaneo nel ratto in seguito a lunghi periodi di presentazione e deprivazione di alcool. Contributi di Psicologia, 1: Rocchi E, Borghi A, Pradelli M, Paolillo F, Casalgrandi G, Benedetti F, Moja EA (1992) Implicazioni cliniche dell'utilizzo di una miscela aminoacidica priva di triptofano nella cirrosi epatica. Recenti Progressi in Medicina, 83: Benedetti F, Moja EA (1992) Comportamento sessuale del ratto femmina in laboratorio: una rassegna delle tecniche di valutazione. Ricerche di Psicologia, XVI, 3: Benedetti F, Barbini B, Colombo C (1997) Fluttuazioni infradiane dell umore durante un episodio depressivo maggiore. [abstract] New Trends in Psichiatria, V, 2: Zanardi R, Benedetti F (1998) Strategie alternative nel trattamento dei disturbi dello spettro depressivo. Bollettino di aggiornamento in Neuropsicofarmacologia, XIV, 68: Colombo C, Benedetti F (1999) L'insonnia di Don Chisciotte. Deprivazione di sonno, neuroscienze e modelli epistemologici. Psichiatria e Psicoterapia Analitica, XVIII, 1: Benedetti F, Barbini B, Campori E, Cigala Fulgosi M, Colombo C, Smeraldi E (2001) Ritmi, sonno e disturbo bipolare. Psichiatri oggi, III, 1: Zanardi R, Serretti A, Rossini D, Benedetti F, Cusin C, Smeraldi E (2001) Strategie di potenziamento della terapia antidepressiva. Psichiatri oggi, III, 1: Bernasconi A, Benedetti F, Colombo C, Smeraldi E. (2003) Luci sulla depressione. Kos 219:

16 Journal Abstracts, peer reviewed (proceedings) A. Clinical chronotherapeutics of mood disorders 1. Barbini B, Benedetti F, Campori E, Guglielmo E, Colombo C, Smeraldi E. (1995) Perceived symptomatology and biological rhythms in unipolar patients. World Conference on Chronobiology and Chronotherapeutics. Biological Rhythms Research, 26: Barbini B, Colombo C, Benedetti F, Campori E, Di Molfetta D, Smeraldi E. (1995) The study of circadian and infradian fluctuations in mood disorders: a methodological approach. World Conference on Chronobiology and Chronotherapeutics. Biological Rhythms Research, 26: Barbini B, Benedetti F, Campori E, Colombo C, Smeraldi E. (1997) Differential effect of total sleep deprivation in unipolar and bipolar depression. 6th World Congress of Biological Psychiatry; 1997 Jun 22-27; Nice. Biological Psychiatry 42 (Suppl 1):109S. 4. Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E. (1997) Patterns of infradian mood variation in major depression. 6th World Congress of Biological Psychiatry; 1997 Jun 22-27; Nice. Biological Psychiatry 42 (Suppl 1):109S. 5. Barbini B, Benedetti F, Campori E, Colombo C, Smeraldi E. (1997) Circadian mood fluctuation as a predictor of the antidepressant response to total sleep deprivation. 6 th World Congress of Biological Psychiatry; 1997 Jun 22-27; Nice. Biological Psychiatry 42(Suppl 1):233S. 6. Benedetti F, Colombo C, Barbini B, Lucca A, Campori E, Cigala Fulgosi M, Smeraldi E (2001) Light and lithium to sustain the rapid effects of total sleep deprivation in bipolar depression. 6 th Regional Meeting of the European College of Neuropsychopharmacology. Napoli, 2001 May European Neuropsychopharmacology, 11(Suppl. 2):S52 7. Benedetti F, Cigala Fulgosi M, Colombo C, Barbini B, Campori E, Smeraldi E (2001) Availability of morning sunlight and response to antidepressant treatments. 6 th Regional Meeting of the European College of Neuropsychopharmacology. Napoli, 2001 May European Neuropsychopharmacology, 11(Suppl. 2):S51 8. Colombo C, Benedetti F, Barbini B, Campori E, Cigala Fulgosi M (2001) Light, lithium and sleep phase advance to sustain the rapid effects of total sleep deprivation in bipolar depression. 7 th World Congress of Biological Psychiatry. Berlin, 2001 July 1-6. The World Journal of Biological Psychiatry, 2(Suppl.1):352S 9. Benedetti F (2001) Light treatment effects in bipolar disorder. Society for Light Treatment and Biological Rhythms, 13 th Annual Meeting. Stockholm, 2001 June Stress Research Reports, 297: Benedetti F, Colombo C, Barbini B, Smeraldi E (2002) Sleep deprivation and biological rhythms in bipolar disorder. 1st Biennal Conference of the International Society for Affective Disorders. Taormina, March Journal of Affective Disorders 68 (1): Benedetti F, Colombo C, Pontiggia A, Bernasconi A, Barbini B, Smeraldi E (2003) Chronobiological treatment of bipolar depression. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology 13(Suppl. 4) :S Bernasconi A, Benedetti F, Colombo C, Pontiggia A, Florita M, Smeraldi E (2003) Morning light therapy as an augmenting strategy of antidepressant treatment. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology13(Suppl. 4) : S Pontiggia A, Benedetti F, Bernasconi A, Florita M, Colombo C, Cropanese I, Smeraldi E (2003) Phase-response effects of lormetazepam in depressive insomnia. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology13(Suppl. 4) : S Benedetti F, Colombo C, Bernasconi A, Barbini B, Cigala Fulgosi M, Pontiggia A, Smeraldi E (2004) Chronobiological treatments of bipolar depression. The International Society for Affective Disorders (ISAD) 2nd Biennial Conference Cancun, Mexico 5th 10th March Journal of Affective Disorders 78(Suppl.1): S Bernasconi A, Benedetti F, Colombo C, Pontiggia A, Florita M, Smeraldi E (2004) Light therapy in the morning: augmenting strategy of antidepressant treatment. World Psychiatric Association International Congress Treatments in Psychiatry: an update. Firenze, November World Psychiatry 3(Suppl. 1): Pontiggia A, Benedetti F, Bernasconi A, Colombo C, Florita M, Dallaspezia S (2004) Phase response effet of lormetazepam in the treatment of depressive insomnia. World Psychiatric Association International Congress Treatments in Psychiatry: an update. Firenze, November World Psychiatry 3(Suppl. 1):

17 17. Benedetti F, Barbini B, Bernasconi A, Cigala Fulgosi M, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E (2005) The role of brain monoamines in the antidepressant response to sleep deprivation. XIII congress of the Association of European Psychiatrists. Munich, Germany, April 2-6. European Psychiatry, 20(Suppl 1):S Benedetti F (2005) Chronobiological treatments of bipolar illness. 8 th World Congress of Biological Psychiatry. Vienna, Austria, June 28 th July 3 rd. World Journal of Biological Psychiatry, 6(Suppl 1):S Cigala Fulgosi M, Pontiggia A, Bernasconi A, Dallaspezia S, Colombo C, Barbini B, Benedetti F (2005). Is sleep deprivation useful in the treatment of resistant bipolar depression? 8 th World Congress of Biological Psychiatry. Vienna, Austria, June 28 th July 3 rd. World Journal of Biological Psychiatry, 6(Suppl 1):S Pontiggia A, Benedetti F, Barbini B, Cigala Fulgosi M, Colombo C, Dallaspezia S, Smeraldi E (2006) Long term outcome of drug-resistant bipolar depression: a 9 months prospective follow-up after chronotherapeutics. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 16(Suppl 1):S Benedetti F (2006) Sleep deprivation and light therapy. 19th congress of the European College of Neuropsychopharmacology, Paris September. European Neuropsychopharmacology, 16 (Suppl 4):S Pontiggia A, Benedetti F, Barbini B, Cigala Fulgosi M, Colombo C, Dallaspezia S, Smeraldi E (2006). An actigraphic registration of depressed patients treated with chronotherapeutics. 19th congress of the European College of Neuropsychopharmacology, Paris September. European Neuropsychopharmacology, 16 (Suppl 4):S Benedetti F (2006) Circadian rhythms and mood disorders: chronotherapeutic implications. 8th World Congress of Psycho-Oncology, Venezia October. Psycho-Oncology, 15(2 Suppl): Benedetti F (2007) Sleep deprivation: a forgotten tool? 7th International Forum on Mood & Anxiety Disorders - Budapest 5-7 December. International Journal of Psychiatry in Clinical Practice, 11(4): Benedetti F, Cigala Fulgosi M, Gavinelli C, Barbini B, Colombo C, Smeraldi E (2007) Homeostatic and allostatic response to sleep deprivation in bipolar depression. 7th International Forum on Mood & Anxiety Disorders - Budapest 5-7 December. International Journal of Psychiatry in Clinical Practice, 11(4): Benedetti F, Fresi F, Maccioni P, Smeraldi E (2008) Manic-like reaction to sleep deprivation in mice follows a cyclical pattern and a dose-response effect. 3rd Biennial Conference of the International Society for Bipolar Disorders, New Dehli-Agra January. Bipolar Disorders, 10(Suppl.1): Benedetti F, Cigala Fulgosi M, Gavinelli C, Lietti L, Dallaspezia S, Barbini B, ColomboC, Smeraldi E (2008) Lower need of homeostatic sleep after successful sleep deprivation therapy of depression. 3rd Biennial Conference of the International Society for Bipolar Disorders, New Dehli-Agra January. Bipolar Disorders, 10(Suppl.1): Benedetti F. The neurobiology of antidepressant response to sleep deprivation. 3rd Biennial Conference of the International Society for Bipolar Disorders, New Dehli-Agra January. Bipolar Disorders, 10(Suppl.1): Benedetti F, Cigala Fulgosi M, Gavinelli C, Barbini B, ColomboC, Smeraldi E (2008) Homeostatic and allostatic response to sleep deprivation in bipolar depression. XXVI Congress of the Collegium Internationale Neuro- Psychopharmacologicum (CINP), Munich July. International Journal of Neuropsychopharmacology, 11(Suppl 1): Benedetti F, Fresi F, Maccioni P, Smeraldi E (2008) Manic-like reaction to sleep deprivation in mice follows a cyclical pattern and a dose-response effect. XXVI Congress of the Collegium Internationale Neuro- Psychopharmacologicum (CINP), Munich July. International Journal of Neuropsychopharmacology, 11(Suppl 1): Benedetti F (2009) Chronotherapeutics to treat bipolar depression in a psychiatric ward. World Psychiatric Association (WPA) International Congress, Firenze, 1-4 April. World Psychiatry 8(Suppl 1): Benedetti F, Colombo C (2009) The clinical usefulness of chronotherapeutics for bipolar disorder: rationale and perspectives. Eighth International Conference on Bipolar Disorder, June, Pittsburgh. Bipolar Disorders, 11(Suppl. 1): 33. Benedetti F (2011) Neuroimaging and genetics of sleep deprivation in depression: from monoamines and glutamate to neuroplasticity. Worldsleep2011: New Horizons Of Sleep Research For Our Planet. Kyoto, October. Sleep and Biological Rhythms 2011; 9: Benedetti F (2011) Glutamatergic Neurotransmission and Synaptic Homeostasis in the Rapid Antidepressant Effect of Sleep Deprivation. American College of Neuropsychopharmacology (ACNP) 50th Annual Meeting, Waikoloa, December 4-8. Neuropsychopharmacology 36:S16. 17

18 B. Psychiatric genetics 35. Benedetti F, Colombo C, Barbini B, Campori E, Cigala Fulgosi M, Serretti A. (2000) Genetic differences in antidepressant response to sleep deprivation. 8 th World Congress on Psychiatric Genetics, Versailles, August American Journal of Medical Genetics 96(4): Zanardi R, Benedetti F, Serretti A, Smeraldi E. (2000) Genetic influence on response to serotonergic antidepressants. 8 th World Congress on Psychiatric Genetics, Versailles, August American Journal of Medical Genetics 96(4): Benedetti F, Colombo C, Barbini B, Campori E, Cigala Fulgosi M, Serretti A, Smeraldi E (2001) Genetic predictors of antidepressant response to total sleep deprivation. 6 th Regional Meeting of the European College of Neuropsychopharmacology. Napoli, 2001 May European Neuropsychopharmacology, 11(Suppl. 2):S Zanardi R, Benedetti F, Serretti A, Smeraldi E (2001) Genetic predictors of response to SSRIs. 6 th Regional Meeting of the European College of Neuropsychopharmacology. Napoli, 2001 May European Neuropsychopharmacology, 11(Suppl. 2):S Colombo C, Benedetti F, Barbini B, Cigala Fulgosi M, Campori E (2001) Genetic predictors of antidepressant response to total sleep deprivation. 7 th World Congress of Biological Psychiatry. Berlin, 2001 July 1-6. The World Journal of Biological Psychiatry, 2(Suppl.1):214S 40. Benedetti F, Colombo C, Barbini B, Campori E, Cigala Fulgosi M, Smeraldi E (2002) Genetic predictors of antidepressant response to sleep deprivation. 14 th Congress of the European College of Neuropsychopharmacology, Istanbul, October European Neuropsychopharmacology, 11 (Suppl. 3), S Serretti A, Cusin C, Lorenzi C, Benedetti F, Pirovano A, Arnoldi A, Zanardi R, Colombo C, Smeraldi E (2003) Genetic predictors of antidepressants efficacy: the state of the art. The XIth World Congress of Psychiatric Genetics. Quebec, 15/09/2003. Vol. American Journal of Medical Genetics, 122B: Benedetti F, Serretti A, Cusin C, Mandelli L, Pirovano A, Zanardi R, Colombo C, Smeraldi E (2003) CLOCK gene influences insomnia during antidepressant treatment. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology13(Suppl. 4) : S Serretti A, Lorenzi C, Benedetti F, Pirovano A, Zanardi R, Colombo C, Ploia C, Tubazio V, Smeraldi E (2004) Genetic polymorphisms influencing response of antidepressants. XXIV CINP Congress. Paris, June. International Journal of Neuropsychopharmacology, 7(Suppl.1):S Serretti A, Lorenzi C, Benedetti F, Pirovano A, Zanardi R, Colombo C, Ploia C, Tubazio V, Smeraldi E (2004) Genetic predictors of antidepressants efficacy: The State of the Art. European Psychiatry, 19(Suppl.1):79S- 79S. 45. Pontiggia A, Bernasconi A, Benedetti F, Serretti A, Lorenzi C, Colombo C, Smeraldi E. (2005) A glycogen synthase kinase 3-β -50 T/C SNP influences long-term response to lithium salts in bipolar illness. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March 3-6. European Neuropsychopharmacology, 15(Suppl 1):S56-S Pontiggia A, Benedetti F, Bernasconi A, Colombo C, Lorenzi C, Serretti A, Smeraldi E (2005) GSK3B and the molecular clock as novel targets in the treatment of bipolar disorder. 8 th World Congress of Biological Psychiatry. Vienna, Austria, June 28 th July 3 rd. World Journal of Biological Psychiatry, 6(Suppl 1):S Benedetti F. (2005) The molecular clock as a target in the treatment of bipolar disorder. 44 th Annual Meeting of the American College of Neuropsychopharmacology. Waikoloa, Hawaii, December. Neuropsychopharmacology, 30(Suppl. 1): S63-S M. Bosia, R. Cavallaro, F. Benedetti, G. Guerriero, F. Cocchi, E. Marino, E. Smeraldi (2007) Association study of GSK-3β -50T/C polymorphism with haloperidol resistance in schizophrenia. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 17(Suppl. 1):S Dallaspezia S, Benedetti F, Colombo C, Barbini B, Smeraldi E (2007) Lithium therapy reverses the influence of 5-HTTLPR gene polymorphism on anti-depressant response to sleep deprivation.. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 17(Suppl. 1):S Benedetti F, Lietti L, Barbini B, Lorenzi C, Marino E, Cigala Fulgosi M, Pontiggia A, Dallaspezia S, Colombo C, Smeraldi E (2007) CLOCK gene polymorphism rs biases response to light treatment after sleep deprivation. International Journal of Psychiatry in Clinical Practice, 11(4): Benedetti F, Lietti L, Barbini B, Cigala Fulgosi M, Dallaspezia S, Lorenzi C, Pirovano A, Pontiggia A, Colombo C, Smeraldi E (2008) Response to light treatment after sleep deprivation is influenced by CLOCK 3111 T/C SNP 18

19 (rs ) gene polymorphism. 3rd Biennial Conference of the International Society for Bipolar Disorders, New Dehli-Agra January. Bipolar Disorders, 10(Suppl.1): Benedetti F, Barbini B, Lorenzi C, Lietti L, Marino E, Cigala Fulgosi M, Pontiggia A, Dallaspezia S, Colombo C, Smeraldi E (2008) Clock gene polymorphism rs biases response to light treatment after sleep deprivation. XXVI Congress of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Munich July. International Journal of Neuropsychopharmacology, 11(Suppl 1):, 11(Suppl 1): Benedetti F (2008) Pharmacogenetics of human therapeutic response to lithium and other therapeutic interventions. XXVI Congress of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Munich July. International Journal of Neuropsychopharmacology, 11(Suppl 1): Benedetti F (2009) Influence of gene variants affecting the Clock on psychopathology and response to treatment in bipolar disorder. Eighth International Conference on Bipolar Disorder, June, Pittsburgh. Bipolar Disorders, 11 (Suppl. 1):1. C. Brain Imaging and genetic correlates of psychiatric diseases and therapeutics 55. Benedetti F, Bernasconi A, Lorenzi C, Pontiggia A, Serretti A, Colombo C, Smeraldi E (2003) Glycogen synthase kinase 3-B influences age at onset of bipolar disorder. XIth World Congress of Psychiatric Genetics. Quebec, 15/09/2003 American Journal of Medical Genetics, 122B: Lorenzi C, Serretti A, Benedetti F, Tubazio V, Ploia C, Colombo C, De Ronchi D, Smeraldi E (2003) Human PERIOD 3 gene influences SSRIs antidepressant activity in mood disorders. The XIth World Congress of Psychiatric Genetics. Quebec, 15/09/2003. American Journal of Medical Genetics, 122B:124. pp. 57. Mandelli L, Serretti A, Benedetti F, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2003) Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. The XIth World Congress of Psychiatric Genetics. Quebec, 15/09/2003. American Journal of Medical Genetics, 122B: Benedetti F, Serretti A, Colombo C, Barbini B, Lorenzi C, Campori E, Smeraldi E (2003) CLOCK gene and circadian mood fluctuations in bipolar depression. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology 13(Suppl. 4) :S Benedetti F, Serretti A, Mandelli L, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2003) Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology13(Suppl. 4) :S Benedetti F, Bernasconi A, Lorenzi C, Pontiggia A, Colombo C, Smeraldi E (2003) Glycogen synthase-kinase 3β influences age at onset of bipolar disorder. 16 th Congress of the European College of Neuropsychopharmacology, Praga, September European Neuropsychopharmacology 13(Suppl. 4) : S Massa R, Serretti A, Benedetti F, Artioli P, Mandelli L, Ploia C, Pirovano A, Smeraldi E (2004) Insomnia and mood diurnal variations in mood disorder patients: the involvement of CLOCK and PER3 genes. XIIth World Congress of Psychiatric Genetics. Dublin, Ireland, 9th 13th October American Journal of Medical Genetics, 130B: Ploia C, Serretti A, Benedetti F, Fontana V, Colombo C, Catalano M, Smeraldi E (2004) Mood disorders and antidepressants treatment: haplotype analysis of human PERIOD 3 gene. XIIth World Congress of Psychiatric Genetics. Dublin, Ireland, 9th 13th October American Journal of Medical Genetics, 130B: Tubazio V, Benedetti F, Serretti A, Ploia C, Pirovano A, Smeraldi E (2004) Glicogen synthase kinase (GSK) gene promoter polymorphisms: a tdt and haplotype approach in mood disorders. XIIth World Congress of Psychiatric Genetics, Dublin, Ireland, 9th 13th October American Journal of Medical Genetics 130B: Serretti A, Artioli P, Mandelli L, Lorenzi C, Benedetti F, Smeraldi E (2004) How do genes exert their role? PER3 variants and possible influences on mood disorder phenotypes. XIIth World Congress of Psychiatric Genetics. Dublin, Ireland, 9th 13th October American Journal of Medical Genetics 130B: Bernasconi A, Radaelli D, Benedetti F, Blasi V, Cadioli M, Colombo C, Falini A, Scotti G, Smeraldi E (2005) Recovery from bipolar depression after total sleep deprivation: a 3.0 T BOLD fmri event-related study of moral thinking. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March 3-6. European Neuropsychopharmacology, 15(Suppl 1):S Radaelli D, Bernasconi A, Benedetti F, Blasi V, Cadioli M, Colombo C, Falini A, Scotti G, Smeraldi E (2005) Neural correlates of distorted moral thinking in bipolar depression: a 3.0 T BOLD fmri event-related study. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March 3-6. European Neuropsychopharmacology, 15(Suppl 1):S63. 19

20 67. Radaelli D, Bernasconi A, Benedetti F, Blasi V, Cadioli M, Colombo C, Falini A, Scotti G, Smeraldi E (2005) Changes in right DLPFC (BA9) after treatment in bipolar depression. 8 th World Congress of Biological Psychiatry. Vienna, Austria, June 28 th July 3 rd. World Journal of Biological Psychiatry, 6(Suppl 1):S Bernasconi A, Radaelli D, Benedetti F, Blasi V, Cadioli M, Colombo C, Falini A, Scotti G, Smeraldi E (2005) Moral thinking and depression: a 3.0T BOLD fmri event-related study. 8 th World Congress of Biological Psychiatry. Vienna, Austria, June 28 th July 3 rd. World Journal of Biological Psychiatry, 6(Suppl 1):S Bernasconi A, Calabrese G, Benedetti F, Radaelli D, Dallaspezia S, Falini A, Colombo C, Cadioli M, Scotti G, Smeraldi E (2006) Changes in brain glutamate correlate with antidepressant response to total sleep deprivation: a 3T 1H-MRS study. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 16(Suppl 1):S Dallaspezia S, Benedetti F, Bernasconi A, Blasi V, Colombo C, Falini A, Radaelli D, Scotti G, Smeraldi E (2006) Influence of brain activity at the baseline on antidepressant response to chronotherapeutic treatment: a fmri study. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 16(Suppl 1):S Radaelli D, Bernasconi A, Benedetti F, Blasi V, Colombo C, Falini A, Scotti G, Smeraldi E (2006) Influence of serotonin transporter promoter polymorphism on brain activation during a moral valence decision task. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 16(Suppl 1):S Bernasconi A, Benedetti F, Blasi V, Cadioli M, Colombo C, Dallaspezia S, Falini A, Radaelli D, Scotti G (2006) A 3 T BOLD functional MRI study of the neural underpinnings of depression. European Neuropsychopharmacology, 16 (Suppl 4):S Dallaspezia S, Benedetti F, Cigala Fulgosi M, Barbini B, Colombo C, Lorenzi C, Serretti A, Smeraldi E (2006) Influence of CLOCK gene polymorphism on sleep-wake cycle in depressed bipolar patients: an actigraphic study. European Neuropsychopharmacology, 16 (Suppl 4):S Radaelli D, Benedetti F, Bernasconi A, Blasi V, Cadioli M, Colombo C, Dallaspezia S, Falini A, Scotti G, Smeraldi E (2006) Neural correlates of emotional self in bipolar disorder: a BOLD functional MRI 3 T study. European Neuropsychopharmacology, 16 (Suppl 4):S Marino E, Lorenzi C, Pirovano A, Benedetti F, Catalano M, Smeraldi E (2007) How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 17(Suppl. 1):S4 76. Poletti S, Benedetti F, Bosia M, Pirovano A, Cocchi F, Smeraldi E (2007) Association study of GSK-3β -50T/C polymorphism with executive performances in schizophrenia. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 17(Suppl. 1):S Radaelli D, Bernasconi A, Benedetti F, Colombo C, Falini A, Scotti G, Smeraldi E (2007) Clock genotype biases neural correlates of moral valence decision in patients affected by bipolar depression. ECNP Workshop on Neuropsychopharmacology for young scientists in Europe. Nice, France, March European Neuropsychopharmacology, 17(Suppl. 1):S Radaelli D, Bernasconi A, Dallaspezia S, Poletti S, Benedetti F, Falini A, Colombo C (2007) Stressful life events bias neural correlates of moral valence decision in patients affected by mood disorder. 20th congress of the European College of Neuropsychopharmacology, Wien October. European Neuropsychopharmacology, 17(Suppl. 4):S Poletti, D. Radaelli, S. Dallaspezia, A. Bernasconi, F. Benedetti, A. Falini, R. Cavallaro (2007) Neural correlates of emotional processing in schizophrenia: an fmri study. 20th congress of the European College of Neuropsychopharmacology, Wien October. European Neuropsychopharmacology, 17(Suppl. 4):S Benedetti F, Radaelli D, Bernasconi A, Dallaspezia S, Unterhofer V, Colombo C, Falini A, Scotti G, Smeraldi E (2007) Stressful life events bias neural correlates of emotional processing in bipolar disorder. 7th International Forum on Mood & Anxiety Disorders - Budapest 5-7 December. International Journal of Psychiatry in Clinical Practice, in press. 81. Benedetti F, Dallaspezia S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E (2007) A VNTR polymorphism in hper3 gene influences clinical characteristic of bipolar disorder. 7th International Forum on Mood & Anxiety Disorders - Budapest 5-7 December. International Journal of Psychiatry in Clinical Practice, 11(4): Benedetti F, Poletti S, Radaelli D, Dallaspezia S, Bernasconi A, Colombo C, Cavallaro R, Falini A, Scotti G, Smeraldi E (2007) Bipolar disorder and schizophrenia influence neural responses in amygdala and anterior cyngulate to emotional faces. 7th International Forum on Mood & Anxiety Disorders - Budapest 5-7 December. International Journal of Psychiatry in Clinical Practice, 11(4):