IV th MEETING NIBIT SCIENTIFIC PROGRAM Certosa di Pontignano Siena

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1 IV th MEETING NIBIT SCIENTIFIC PROGRAM Certosa di Pontignano Siena Friday - September 29, 2006 Sala Bracci Ore 8.15: Ore 8.30: Welcome address Keynote lecture: Harnessing inkt cells for the development of cancer vaccines Vincenzo Cerundolo (Oxford, UK) Session 1 New antigens and new cytokines Chairs: Chiara Castelli (Milan), Paolo Ascierto (Naples) Ore 9.00: Ore 9.20: Ore 9.40: Ore 10.00: Vaccinations with universal antigens (Survivin) Chiara Castelli (Milan) IL-2 family members and tumor immunotherapy: pre-clinical studies and perspectives Silvano Ferrini (Genoa) Activation of toll-like receptors in the regulation of tumor growth Andrea Balsari (Milan) Functional role of chemokines in melanoma progression Stefania Scala (Naples) Ore : Discussion Ore : Coffee break Session 2 Immunemonitoring in the course of immunotherapy: Workshop Chairs: Paola Nisticò (Rome), Licia Rivoltini (Milan) Ore 11.00: Ore 11.15: Quantitative and qualitative CD8+ T cell parameters for the immune monitoring of cancer vaccine efficacy Susanna Mandruzzato (Padua), Paola Zanovello (Padua) Multi-peptide vaccination in high risk stage II-III melanoma patients: are we boosting the right immune responses for preventing disease recurrence? Licia Rivoltini (Milan)

2 Ore 11.30: Ore 11.45: Ore 12.00: Ore 12.15: Monitoring by IFN-γ ELISPOT and HLA-A2 tetramers in melanoma patients Paola Nisticò (Rome) Monitoring of antigen-specific T cell responses by microcultures Vincenzo Russo (Milan) Monitoring of spontaneous and vaccine induced antigen specific T cell responses Maria Pia Protti (Milan) T cell response in melanoma patients vaccinated with anti-idiotypic antibodies Massimo Guidoboni (Siena), Hugues Nicolay (Siena) Ore : Discussion and proposal for a cooperative program Ore : Lunch Session 3 Alpha Interferon: novel uses for an old cytokine Chairs: Paola Queirolo (Genoa), Ruggero Ridolfi (Forlì) Ore 14.00: Ore 14.20: Ore 14.40: IFN-α and activation of the immune system Filippo Belardelli (Rome) IFN-α in metastatic melanoma: is there a role for doses and routes of administration? Vanna Chiarion Sileni (Padua) Proposal for a new clinical study NIBIT Michele Maio (Siena), Giorgio Parmiani (Milan) Ore : Discussion Session 4 Vaccination in prostate cancer Chairs: Marco Bregni (Milan), Alessandro Testori (Milan) Ore 15.20: Ore 15.40: Pre-clinical model of immunotherapy Matteo Bellone (Milan) Role of infiltrating lymphocytes Vincenzo Bronte (Padua) Ore : Coffee break Ore 16.30: Vaccination with multipeptides in localized disease Andrea Marrari (Milan)

3 Ore 16.50: Vaccination with dendritic cells Lina Matera (Turin) Ore : Discussion Session 5 Novel strategies of combined immunotherapy Chairs: Salvatore Siena (Milan), Claudio Bordignon (Milan) Ore 17.30: Ore 17.50: Ore 18.10: Therapeutic strategies combining hematopoietic stem cell transplantation with adoptive immunotherapy in solid tumors, proposal of collaboration with GITMO Marco Bregni (Milan), Paolo Pedrazzoli (Milan) Allo-transplantation in solid tumors Massimo Aglietta (Turin) Rational for combining radiotherapy and immunotherapy in solid tumors: a possible novel approach? Round Table - Chair: Claudio Bordignon (Milan) Speakers: Mauro Trovò (Aviano, PN) Principles and clinical applications of tomotherapy Angelo Manfredi (Milan) Immunobiologic role of radiotherapy in solid tumors Ore : Discussion Ore 20.00: Dinner Ore 22.00: General Assembly of NIBIT Saturday - September 30, 2006 Sala Bracci Ore 8.30: Keynote lecture: NK cells in the treatment of hemopoietic tumors Andrea Velardi (Perugia) Session 6 Clinical studies: Up-date and New Programs Chairs: Giorgio Parmiani (Milan), Michele Maio (Siena) Ore 9.00: Thymosin alpha in metastatic melanoma Roberto Camerini (Sigma Tau, Rome)

4 Ore 9.15: Ore 9.30: Ore 9.45: Ore 10.00: Ore 10.15: Ore 10.30: Ore 10.45: CTLA-4 in solid tumors Carlo Lanza (Pfizer, Milan) Vaccination of melanoma patients with salmonella Maria Rescigno (Milan) Chemo-immunotherapy in melanoma patients Enrico Proietti (Rome) MAGE-3-transduced lymphocytes Vincenzo Russo (Milan) DCs pulsed with allogeneic melanoma peptidome Maria Pia Protti (Milan) Vaccination with dendritic cells pulsed with autologous tumor cell lysates Michele Guida (Bari) Vaccination with multipeptides of stage III melanoma patients Lorenzo Pilla (Milan) Ore : Coffee break Ore 11.30: Ore 11.45: Ore 12.00: Ore 12.15: Ore 12.30: Ore 12.45: Vaccination with autologous monocytes pulsed with tumor cell lysates and activated by extracorporeal photochemoterapy Marco Danova (Pavia), Cesare Perotti (Pavia) Clinical development of a new cancer vaccine platform based on the combination of DNA-muscle electroporation and adenoviral vectors Elisa Scarselli (Merck, Rome) GLP production of anti-tumor CTL lines for adoptive cell therapy in patients with solid tumors Daniela Montagna (Pavia) Adoptive immunotherapy in hemopoietic malignances Chiara Bonini (Milan) Vaccination of lymphoma patients with autologous dendritic cells pulsed with apoptotic/necrotic tumor cells exposed to heat-shock Massimo Di Nicola (Milan) BCR-ABL derived vaccines in chronic myeloid leukemia Monica Bocchia (Siena), Francesco Lauria (Siena) Ore 13.00: Discussion Ore 13.30: Buffet

5 COME RAGGIUNGERE LA CERTOSA DI PONTIGNANO IN AUTO Da Nord Provenendo dal Raccordo Firenze/Siena, Uscita Siena Nord. Al primo STOP voltare a sinistra, direzione CASTELLINA IN CHIANTI-GREVE IN CHIANTI (SR 222),dopo circa 1,5 km, bivio sulla destra direzione VAGLIAGLI-CORSIGNANO-PIEVASCIATA (SP 102) e PONTIGNANO (marrone), si prosegue per altri 2,5 km e si trova sulla sinistra la fattoria di VALIANO, superata di circa 1,5 km, sulla destra bivio per PONTIGNANO 1-PONTE A BOZZONE-SS 406. Si prosegue per altri 2 km circa e si arriva alla Certosa di Pontignano. Da Sud Provenendo dal Raccordo Bettole/Siena, Uscita Siena Est (praticamente la prosecuzione del Raccordo) e si prosegue seguendo le indicazioni CENTRO STAZIONE FF.SS. Nel percorso si trovano delle rotatorie. Alla terza rotatoria si trovano le indicazioni per CERTOSA DI PONTIGNANO. Si prosegue lungo la strada statale 408 per circa 7/8 km fino alla località PONTE A BOZZONE, lì si gira a sinistra in direzione CERTOSA DI PONTIGNANO. Si prosegue per 2 km e si arriva alla Certosa di Pontignano