Training in influenza surveillance and research

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1 Curriculum Vitae PERSONAL INFORMATION Daniela Mattei WORK EXPERIENCE July 2011 Present Research Scientist at the National Center for Immunobiological Research and Evaluation (CRIVIB) Istituto Superiore di Sanità, (Italy) Evaluation and control activities relating to Batch Release of influenza vaccines (seasonal or pandemic) for the EU market (as part of the Official Control Authority Batch Release (OCABR) and for the non-eu market. Activities of post-marketing surveillance of influenza vaccines for human use within the national program, for verification of the declared characteristics of quality. Research activities on correlates of protection from influenza disease by serological assays. July 2002 June 2010 Reserch Scientist at the Dept. of Environment and Primary Prevention Istituto Superiore di Sanità, (Italy) Risk assessment of environmental xenobiotics by the development of biological systems and ecotoxicological methods. Fields of investigation involved contaminants in drinking and bathing waters, cyanotoxins and phycotoxins in microalgae and seafood. Evaluation of exposure of population at chemical elements by the development of simultaneous analytical determination by SF-ICP-MS (Sector Field Inductively Coupled Plasma Mass Spectrometry). EDUCATION AND TRAINING December 2012 October 2013 Master Auditor Dept. of Physiology and Pharmacology of the University of Rome Master in Drug Regulatory Science. Topics such as the regulatory framework, drug development, assessment and registration of medicinal products, vaccines, herbal and homeopathic medicinal products were studied and a final test for each topic was passed. July 2012 Training in influenza surveillance and research Molecular Epidemiology Research Division of the University of Siena Summer school on influenza: skills in influenza viruses surveillance and characterization Ph.D in Chemical Sciences Dept. of Chemical Sciences and Technology of the University of Rome Experimental thesis entitled: "Spectrometric techniques applied to the assessment of human exposure to trace elements" Master Degree (110/110 cum laude) Dept. of Biochemical Sciences of the University of Rome Bioinformatics: Biomedical and pharmaceutical applications Degree in Biological Sciences (110/110 cum laude) Experimental Ecology and Aquaculture lab. of the University of Rome 13/1/15 European Union, Page 1 / 5

2 Experimental thesis entitled: "Ecotoxicological evaluation of water disinfectants: field measurements and laboratory tests" ADDITIONAL INFORMATION Expertise Publications Migliore L., Tancioni L., Mattei D., Mancini L., Cataudella S Ecotoxicity testing of Tiber River water as compared to CLO2, NACLO & PAA. In: Casagrandi, R. & Melià, P. (Eds.) Ecologia. Atti XIII Congresso Nazionale di Ecologia (Como 8-10 Settembre 2003) Aracne, Roma(online).URL: Mattei D., Melchiorre S., Messineo V., Bruno M Toxic algal blooms: monitoring, remedial strategies and experiences on Italian lakes. In: Recent Res. Devel. Environ. Biol., 1 (1), Research Signpost. 1: Bruno M., Messineo V., Mattei D., Melchiorre S Dinamica di specie algali tossiche nei laghi di Albano e Nemi. Rapporti Istisan 04/32: Mattei D., Messineo V., Melchiorre S Tossine di alghe pirrofite. Ambiente Risorse e Salute 2005;101: Manti G:, Mattei D., Messineo V., Melchiorre S., Bogialli S., Sechi N., Casiddu P., Lugliè A., Bruno M First report of Cylindrospermopsis raciborskii in Italy. Harmful Algae News, 28: 8-9. Mattei D., Mancini L., Migliore L., Tancioni L., Cataudella S Effetti di un impianto di depurazione sul fiume Tevere: tossicità su Daphnia e qualità biologica delle acque. Biologia Ambientale 19(1): , Marchini S., Mattei D., Sorace A., Pierdominici E., Formichetti P., Mancini L Valutazione biologica ed ecotossicologicadi sedimenti fluviali. Un esempio di approccio integrato. Biologia Ambientale, 19(1): , Alessi E., Mattei D., Migliore L Qualità dell ambiente marino costiero e acquacoltura intensiva. In: Pasolini B., Alessi E., De Medici D. (Ed.). Workshop di aggiornamento su problematiche emergenti nel settore dei prodotti ittici, Istituto Superiore di Sanità, Roma Maggio Rapporti Istisan 5/24; p Mattei D., Melchiorre S., Messineo V., Bruno M. (Ed.) Diffusione delle fioriture algali tossiche nelle acque italiane: gestione del rischio ed evidenze epidemiologiche. Rapporti Istisan 5/29; p 156. Mattei D., Bruno M Fioriture tossiche marine: nuovi sistemi di controllo e ipotesi di gestione. In: Mattei D., Melchiorre S., Messineo V., Bruno M. (Eds.). Diffusione delle fioriture algali tossiche nelle acque italiane: gestione del rischio ed evidenze epidemiologiche. Rapporti Istisan 05/29, p Bruno M., Fiori M., Mattei D., Melchiorre S., Messineo V., Volpi F., Bogialli S., Nazzari M ELISA and LC-MS/MS method for determinig cyanobacterial toxins in blue-green algae food supplements. Natural product research. 20(9), pp Messineo V., Mattei D., Melchiorre S., Salvatore G., Bogialli S., Salzano R., Mazza R., Capelli G., Bruno M Microcystin diversity in a Planktothrix rubescens population from Lake Albano (Central Italy). Toxicon 48: Migliore L., Mancini L., Mattei D., Tancioni L., Cataudella S., Tiber River quality in a stretch of a sewage treatment plant: toxicity of river water or disinfectants to Daphnia and alteration of benthic macroinvertebrates community. Water air and soil polution, 177: Migliore L., Alessi E., Mattei D., Mancini L., Pierdominici E., Thaller M.C Incidence of antibiotic resistance in the microbial community of the river Tiber (Rome). Fresenius and Environmental Bulletin,15(9): Salvatore G., Grillo C., Mattei D., Bruno M Analisi SPME-HS/GC-MS di campioni della fioritura di Ostreopsis ovata del 2005 (Genova, Liguria). Rapporti Istisan 06/09, pp.43. Mattei D., Messineo V., Algali Tossine e Cianotossine, pp , III Aggiornamento della Seconda Edizione dell Enciclopedia Medica Italiana, UTET, Torino. Mattei D., Salvatore G., Bruno M Harmful algal blooms: new methods of control and management. International Journal of Environment and Health, 1(3): Mattei D., Stefanelli M Distribuzione e fisiologia dei cianobatteri potenzialmente tossici in Italia. In: Funari E., Scardala S., Testai E. (Eds.) Cianobatteri potenzialmente tossici: aspetti ecologici, metodologici e valutazione del rischio. Rapporti Istisan, 08/06: /1/15 European Union, Page 2 / 5

3 Testai E., Mattei D Metodi biologici per la rilevazione delle ciano tossine. In: Funari E., Scardala S., Testai E. (Eds.) Cianobatteri potenzialmente tossici: aspetti ecologici, metodologici e valutazione del rischio. Rapporti Istisan, 08/06: Marchini S., Sorace A., Mattei D., Pierdominici E., Rosa S Valutazione ecotossicologica delle acque e dei sedimenti. In: Mancini L., Pace G. (Eds.) Strategie di protezione e indicatori delle risorse idriche: studio pilota. Rapporti Istisan 08/15: Formichetti P., Morgana J.G., Izzo G., Mancini L.La qualità ambientale del Fosso della Casaccia (Roma). Valutazione dell impatto ecologico dello scarico di acque reflue del Centro Ricerche ENEA Casaccia Rapporti ISTISAN 08/20, pp Manganelli, M., Scardala S., Stefanelli M., Vichi S., Mattei D., Bogialli S., Ceccarelli P., Corradetti E., Petrucci I., Gemma S., Testai E., Funari E Health risk evaluation associated to Planktothrix rubescens: An integrated approach to design tailored monitoring programs for human exposure to cyanotoxins, Water Research, 44: Cianobatteri in acque destinate a consumo umano. Stato delle conoscenze per la valutazione del rischio. Volume 1. A cura di Luca Lucentini e Massimo Ottaviani per il "Gruppo nazionale per la gestione del rischio cianobatteri in acque destinate a consumo umano" Rapporti ISTISAN: 11/35 Pt. 1, 165 p. Cianobatteri in acque destinate a consumo umano. Linee guida per la gestione del rischio. Volume 2. A cura di Luca Lucentini e Massimo Ottaviani per il "Gruppo nazionale per la gestione del rischio cianobatteri in acque destinate a consumo umano" 2011, Rapporti ISTISAN: 11/35 Pt. 2, 67 p. Scardala S, Di Girolamo I, Fattorusso E, Funari E, Gramaccioni L, Grillo C, Icardi G, Mattei D, Poletti R, Testai E. Risk management of Ostreopsis spp. blooms along Italian coasts. Journal of Coastal Research, in press. Bocca B., Lamazza A., Pino A., De Masi E., Iacomino M., Mattei D., Rahimi S., Fiori E., Schillaci A., Alimonti A., Forte G Determination of 30 elements in colorectal biopsies by sector field inductively coupled plasma mass spectrometry: method development and preliminary baseline levels. Rapid Communication in Mass Spectrometry, 21: Bocca B., Mattei D., Pino A., Alimonti A La concentrazione dei metalli nell organismo umano, prima parte Sicurezza Sanitaria, 93:2-1. Bocca B., Mattei D., Pino A., Alimonti A La concentrazione dei metalli nell organismo umano, seconda parte Sicurezza Sanitaria, 94:4-15. Bocca B, Conti ME, Pino A, Mattei D, Forte G, Alimonti A Simple, fast, and low-contamination microwave-assisted digestion procedures for the determination of chemical elements in biological and environmental matrices by sector field ICP-MS. International journal of environmental analytical chemistry. 87(15): Bocca B., Mattei D., Pino A., Alimonti A Contenuto dei metalli nell organismo, prima parte, Ambiente, 68: Alimonti A, Bocca B, Lamazza A, Forte G, Rahimi S, Mattei D, Fiori E, Iacomino M, Schillaci A, De Masi E, Pino A A study on metals content in patients with colorectal polyps. Journal of toxicology and environmental health. Part A.71(5): Bocca B., Mattei D., Pino A., Alimonti A Contenuto dei metalli nell organismo. Seconda parte. Ambiente, 69: Alimonti A, Mattei D. Biomarkers for human biomonitoring. In: Conti ME, ed. Biological monitoring: theory & applications. Bioindicators and biomarkers for environmental quality and human exposure assessment. Southampton: WITPress Publisher; p Alimonti A., Bocca B., Mattei D., Pino A., Femia S., Iacomino M., Lamazza A., Forte G Composition in essential and non-essential elements of tissues and body fluids of healthy subjects and patients with colorectal polyps. International Journal of Environment and Health, 3(2): Alimonti A., Mattei D Attenzione per l ambiente e prevenzione della salute. Decidere in medicina, 4: 2-6. Bocca B, Mattei D, Pino A, Alimonti A. Campagna nazionale di biomonitoraggio dell'esposizione ai metalli: il progetto PROBE. Notiziario dell'istituto Superiore di Sanità. 2010;23(05):3-6. Alimonti A., Bocca B., Mattei D., Pino A. Biomonitoraggio della popolazione italiana per l esposizione ai metalli: valori di riferimento Rapporti Istisan, 2010, 58 p. Bocca B., Mattei D., Pino A., Alimonti A. Uncertainty evaluation in the analysis of biological samples by sector field inductively coupled plasma mass spectrometry. Part A: measurements of Be, Cd, Hg, Ir, Pb, Pd, Pt, Rh, Sb, U, Tl and W in human serum, Rapid Communications in Mass Spectrometry (16): /1/15 European Union, Page 3 / 5

4 Beatrice Bocca, Daniela Mattei, Anna Pino and Alessandro Alimonti. Italian network for human biomonitoring of metals: preliminary results from two Regions. Annali Istituto Superiore di Sanità, Annali Istituto Superiore Sanità 2010 Vol. 46, No. 3: Beatrice Bocca, Daniela Mattei, Anna Pino and Alessandro Alimonti. Uncertainty evaluation in the analysis of biological samples by sector field inductively coupled plasma mass spectrometry. Part B. Measurements of As, Co, Cr, Mn, Mo, Ni, Sn and V in human serum. Rapid Communications in Mass Spectrometry 2011, 24: Beatrice Bocca, Daniela Mattei, Anna Pino and Alessandro Alimonti Monitoring of Environmental Metals in Human Blood: The Need for Data Validation. Current Analytical Chemistry Volume 7, Number 4, October Alimonti A, Bocca B, Mattei D, Pino A. Programme for biomonitoring the Italian population exposure (PROBE): internal dose of metals. Roma: Istituto Superiore di Sanità; (Rapporti ISTISAN 11/09). D'Ilio S, Mattei D, Blasi MF, Alimonti A, Bogialli S. The occurrence of chemical elements and POPs in loggerhead turtles (Caretta caretta): an overview. Marine pollution bulletin 2011;62(8): Alimonti A, Bocca B, Mattei D, Pino A. Programma per il biomonitoraggio dell esposizione della popolazione italiana (PROBE): dose interna dei metalli. Roma: Istituto Superiore di Sanità; (Rapporti ISTISAN 11/09 IT). Iavicoli I., Fontana L., Bergamaschi A., Conti M.E., Pino A.,Mattei D., Bocca B., Alimonti A. Sub- Chronic Oral Exposure to Iridium (III) Chloride Hydrate in Female Wistar Rats: Distribution and Excretion of the Metal. Dose-Responsedoi: /dose-response Iavicoli. Pino A, Amato A, Alimonti A, Mattei D, Bocca B. Human biomonitoring for metals in Italian urban adolescents: data from Latium Region. International journal of hygiene and environmental health 2012;215(2): Iavicoli I, Fontana L, Bergamaschi A, Conti ME, Pino A, Mattei D, Bocca B, Alimonti A. Sub-chronic oral exposure to iridium (III) chloride hydrate in female wistar rats: distribution and excretion of the metal. Dose-response 2012;10(3): ; EU Batch release Procedure Human Vaccines Annual Report 2012; EU Batch release Procedure Human Vaccines Annual Report Projects "Drinkable Water and Emerging Health Risks (PARSE)" - Italian Ministry of Health ( ) CCM-ISS project "Monitoring Water and Health"- Italian Ministry of Health ( ) Project No. 502 intramural funds. 1123/RI and 2123/RI: "Sustainability indicators for integrated assessment of human impacts on surface water and strategies for protecting water resources for the population: the case study of the Tiber River basin ( )" ANPA - ISS Project "Development of a proposed surface water;monitoring. Biological and ecotoxicological methods ( ) ISS - ENEA project -"Impact assessment of the industrial waste water of the CR Casaccia on the ecological status of the receiving water body " ( ) Project: ISS-Lazio Region "Study on characterization and monitoring of water bodies of surface water and groundwater underlying the recharge areas of the lakes of Nemi and Albano Project-ISS Province of Ascoli Piceno ( ) "Convention for the monitoring of water and sediments of the artificial lake of Gerosa aimed at studying the presence of toxic cyanobacteria (Planktothrix rubescens)" Project "Role of neurotoxic chemicals and genetic component in the etiopathology of neurodegenerative diseases (Neurotox)" - Research to the Ministry of Health ( ) CCM-ISS project (Ministry of Health) Probe: "A program of biomonitoring of exposure of the general population ( ) LILT-ISS project "Predictive value of changes in the framework of primary and oxidative stress in colorectal cancer" ( ) LILT-ISS project "Predictive value of changes in the framework of primary and oxidative stress in colorectal cancer"( ) ISS project-afar "Preliminary study for supplementation of olive oil in the feeding of severely preterm infant" ( ) Bagnoli Futura spa-iss project: "Agreement of cooperation for environmental monitoring and for epidemiological survey in the former industrial area of Bagnoli-Naples" ( ) 13/1/15 European Union, Page 4 / 5

5 Tuscany Region-ISS project "Identification of risk profiles in the population for the development of prevention interventions" Twinning Project: Water Quality Management EG/07/AA/EN09 Twinning Project: TR/09/IB//FI/01 Quality Control Tests for Human Vaccines and Sera Memberships Other Relevant Information 13/1/15 European Union, Page 5 / 5