ISC Istituto Sistemi Complessi

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1 ISC Istituto Sistemi Complessi Valentina Mussi ISC-CNR Area della Ricerca Roma Tor Vergata

2 ISC Organization Director of the Institute Prof. Claudio Conti Department of Physics University La Sapienza ISC Units Directorate and central administration Via dei Taurini 19, Roma Sapienza Physics Department Tor Vergata Area della Ricerca di Tor Vergata Montelibretti Area della Ricerca di Roma Montelibretti Sesto Fiorentino Area della Ricerca di Firenze

3 ISC Research and keywords The Institute is dedicated to the study of complex systems, that is to analyze the emergence of collective properties in systems with a large number of interacting components. They may be atoms or cells, in a physical or biological context, or persons, machines or companies in a social and economic framework. STRONGLY MULTI-DISCIPLINARY CHARACTER Biological Physics Condensed Matter Granular Systems Nonlinear Dynamics Optics and Photonics Quantum Physics Soft Matter Statistical Physics Econo-physics

4 ISC Tor Vergata Doping, defects and ferromagnetism in oxide- based materials; Anelasticity of perovskites and perovskite-like materials (ferroelectric, relaxors, ion conductors, superconductors, magnetic); Laser growth and processing of thin films and nanostructures; Miniaturization of devices for space missions (in collaboration with INAF and IMM for ESA mission Bepi Colombo); Label-free micro-spectroscopic characterization of inorganic and biological materials (Hyperspectral Confocal Microscopy, Raman Microscopy); «Life science», diagnostics, bioanalytics, biosensing..

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6 A virtual laboratory: Resources and fields of application

7 Trends in Biophysics & Bioengineering 18 & 19 May 2017 Aula Convegni CNR, Piazzale Aldo Moro Topics and subjects: Microfluidics Microscopy and Spectroscopy Sensors and Devices Lab-on-Chips Complexity Novel Materials Regenerative Medicine Laser Processing Soft Materials Computational Biophysics Molecular Biophysics Bioinformatics and System Biology Biochemistry Models Medical Physics Quantum Effects Confirmed Invited Speakers: Piero Angela Giorgio Parisi Physics Department, University of Rome La Sapienza Giuseppe Remuzzi IRCCS-Mario Negri, Bergamo; Department of Medicine, Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, Bergamo; Department of Biomedical and Clinical Sciences, University of Milano Valentina C. Dinca NILPRP, National Institute for Lasers, Plasma, and Radiation Physics, Magurele, Romania Miguel A. Correa-Duarte Team Nano Tech, Department of Physical Chemistry, University of Vigo, Spain Anna Maria Masci Duke University Medical Center Durham, United States

8 VISLab 1,0 Raman Intensity (a.u.) 0,8 0,6 0,4 0,2 0, Raman Shift (cm-1)

9 ISC-ISM: Raman Imaging Red Blood Cells ageing 1,0 0,8 Raman Intensity (a.u.) 0,6 0,4 0,2 0, Raman Shift (cm -1 ) 1635 cm cm cm cm -1

10 ISC-IFT: Multivariate Statistical Analysis Cells identification and stem cells differentiation 0.10 PC12 CaCO ,0 0,8 PC12 CaCO picco usato per la normalizzazione AMINE? PC2 (12.41% of variance) Raman Intensity (a.u.) 0,6 0,4 0, PC1 (80.14% of variance) 0, Raman shift (cm -1 )

11 ISC-IMM: Biosensors SERS effect from SNW 2 µm 400 SNW + Au SNW + Au + Cyst SNW + Au + Cyst + Avd Raman Intensity (a.u.) Raman shift (cm -1 )

12 ISC ISTITUTO SISTEMI COMPLESSI Claudio Conti Valentina Mussi