SAPIENZA Università di Roma

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1 SAPIENZA Università di Roma Domanda di finanziamento per Progetti di AVVIO ALLA RICERCA Anno prot. C26N1557MN 1. Dati Generali /General Information Responsabile della ricerca / Principal Investigator ZACCAGNA (cognome) Fulvio (nome) Dottorando (qualifica) 08/12/1983 (data di nascita) Medicina interna e specialità mediche (Dipartimento) V.le del Policlinico, ROMA (indirizzo) C Macroarea (delibera del S.A del ) (telefono) (fax) f.zaccagna@gmail.com ( ) Curriculum del proponente/curriculum of the Principal Investigator CURRENT POSITION 11/13 - Present: PhD student in Biotechnology in Clinical Medicine PROFESSIONAL REGISTRATION 07/14 - General Medical Council (Full registration - UK): /09 - Ordine dei Medici Chirurghi e Odontoiatri (Full registration - IT): 5722 PRIZES AND AWARDS 12/13 - RSNA Trainee Research Prize 11/13 - ESOR Certificate of Appreciation 09/12-12/12 - ESOR Neuroradiology Scholarship Sapienza Scholarship A.Y Sapienza Scholarship A.Y Sapienza Scholarship A.Y Sapienza Scholarship A.Y CAREER 07/09-07/14 Specialty Training in Radiology (University of Rome - Sapienza) 12/12-04/13 Honorary Research Fellowship (University of Cambridge) 09/12-12/12 ESOR Neuroradiology Fellowship (University of Cambridge) 07/08-07/09 Clinical and Research Internship (University of Rome - Sapienza) 09/02-07/08 Doctor of Medicine, MD, 110/110 cum Laude (University of Rome - Sapienza) RESEARCH AND TEACHING ACTIVITY Author and co-author of: - 29 Papers: Total IF = ; H Index = 9; - 16 Chapters within 6 books; - 6 Case reports on AuntMinnieEurope.com; - 7 Posters at national and international meetings. 5 Invited lectures at national and international courses and congresses; 26 Presentations at national and international meetings (i.e. RSNA, ECR, CIRSE and SIRM); Author and co-author of more than 81 abstracts at international meetings (i.e. RSNA, ECR; ASNR, EAS and SIRM).

2 Classe dimensionale di finanziamento / Funding class of the proposal Per il TIPO 1: il proponente dovrà essere di età minore o uguale a 32 anni. Per il TIPO 2: il proponente dovrà essere di età minore o uguale a 35 anni. TIPO 2: n. 50 progetti da 4000 euro Data conseguimento Laurea Magistrale Validità per il TIPO 1: dal 9 maggio 2011 (meno di 4 anni dalla laurea magistrale) e età minore o uguale a 32 nni. Validità per il TIPO 2: dal 8 maggio 2005 (max 10 anni dalla laurea magistrale) e età minore o uguale a 35 anni. 29/07/2008 Titolo del progetto / Project title CT texture analysis of carotid vulnerable plaque: a preliminary outcome study in symptomatic patients with Stroke and Transient Ischaemic Attack. Abstract (max 2000 caratteri)/abstract (max 2000 characters) The purpose of this study is to evaluate the potential role of CT texture as a marker of plaque vulnerability. A retrospective case-control study will be conducted to analyse potential differences in texture parameters of carotid arteries plaques in symptomatic and asymptomatic patients in order to identify potential clues of vulnerability. From a historical study population of 341 patients with cardiovascular risk factors, we will depict patients with carotid atherosclerosis and a subsequent history of Transient Ischemic Attack (TIA) or Stroke. These patients will be age and sex matched with control cases with asymptomatic carotid atherosclerosis (follow-up time ±9.2 months). Carotid artery stenosis and plaque composition (lipid, calcified or mixed) will be determined. Texture analysis will be performed using a commercially available software package (TexRAD, Somerset, UK) by a single operator blinded to clinical data. TexRAD uses a filtration-histogram based texture analysis technique to extract pixel size based (fine, medium, coarse) features and quantified histogram parameters including Kurtosis (K), skewness (S) and normalized standard-deviation (SDn). A single axial slice will be selected to best represent the carotid bifurcation for each side and a region of interest (ROI) will be manually delineated in order to fully enclose the artery. Statistical analysis will be performed using?2, t-test and Mann-Whitney test as appropriate. 2. Informazione sull'attività di ricerca / Information about the research activity 2.1 Parole chiave / Key words 1. STROKE 2. TRANSIENT ISCHAEMIC ATTACK 3. COMPUTED TOMOGRAPHY ANGIOGRAPHY 4. TEXTURE ANALYSIS 5. VULNERABLE PLAQUE 2.2 Ambito della ricerca / Research ambit Interdipartimento 2.3 Altri componenti il gruppo di ricerca / Other participants in the research program Solo assegnisti, dottorandi e specializzandi. nº Cognome Nome Qualifica Dipartimento 1. Dottorando DIP. Medicina interna e specialità mediche 2.4 Inquadramento della ricerca proposta (in ambito nazionale ed internazionale) / National - international framing of the research program The Global Burden of Diseases Study 2013 advocates stroke as the second cause of death in the developed country and the third worldwide. Moreover, despite a decrease in mortality rates, the global burden of stroke is significantly and constantly increased since In the last thirty years, it has been widely established that carotid artery disease is responsible for nearly 25-30% of ischemic strokes. In the early '90, the NASCET and the ESCT proved the usefulness of carotid endarterectomy (CEA) and carotid artery angioplasty and stenting (CAS) in patients with 70 to 99% carotid stenosis. According to them, non-invasive techniques use luminal stenosis to quantify severity of atherosclerotic disease at carotid arteries. However, lesions causing moderate stenosis are far more frequent than stenotic plaques and these lesions account for the majority of culprit plaques. Therefore, in the last decade, several papers claimed the need to identify better tools to assess risk stratification. This need has lead to the definition of the vulnerable plaque as a plaque with a high probability of undergoing rapid progression, becoming a culprit lesion. (1) In the definition of vulnerability, key factors are plaque composition and biomechanical forces exercised by blood flow over the plaque itself. (1,2) A consensus panel indicated large lipid-rich necrotic core, thin fibrous cap, fissured cap, active inflammation, superficial calcified nodules, and intraplaque haemorrhage as criteria for defining vulnerable plaque. (1) The key importance of plaque composition in determining stroke risk resulted in a classification promoted by the American Heart Association (AHA) and subsequent modifications. (3) Whilst Digital Subtracted Angiography has been the reference standard for stenosis degree evaluation, it cannot evaluate plaque composition due to his intrinsic nature. Multiparametric MRI has shown the ability to depict features of vulnerable carotid plaque demonstrating good agreement with ex vivo histological analysis of specific plaque components and, therefore, imposing itself as a comprehensive tool for carotid arteries evaluation. (4, 5) However, these new MRI protocols are time consuming, lasting usually more than 30 minutes, and require dedicated and specialized surface coils which are usually available only in selected centres. CTA is faster, easier and widely available; moreover, it is a robust technique to evaluate carotid arteries stenosis and plaque morphology. (6) Furthermore, several studies have demonstrated that CTA is capable of characterizing plaque composition showing good correlation with histology. (7)

3 During the last decades several methods to extract more information from standard images have been proposed, the so-called texture analysis. (8) Texture analysis refers to a variety of mathematical and statistical techniques that can be used to describe the relationships between the grey level intensity of images component and their position within the image itself. Analysis of texture features within tumours on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) is emerging as a potentially useful tool in assessing prognosis and treatment response for patients with cancer. (9-11) Whilst papers have been rapidly accumulating in the above-mentioned field and in brain imaging applications, the evidence for texture analysis in cardiovascular imaging is only just emerging (12). CT derived texture analysis of atherosclerotic plaques has been proven to significantly correlate with histological evaluation. Therefore we designed this study to assess the potential role of texture analysis in carotid arteries imaging. The principal hypothesis behind this study is that texture of atherosclerotic plaque might be different between symptomatic and asymptomatic patients so that texture parameters could become complementary information to assess risk stratification. 2.5 Sintesi del programma di ricerca e descrizione dei compiti dei singoli partecipanti / Synthesis of the research program and description of the duties of each participant Primary objective The primary purpose of this study is to study texture of atherosclerotic plaque in order to underline parameters useful to detect vulnerable plaque and therefore improve risk stratification in patients with carotid artery disease. Patients' enrolment This study is designed as a retrospective case-control study with a ratio 1:1. The CTA dataset will be selected from a study population of 341 patients with cardiovascular risk factors, which underwent CTA at our Department of Radiology for a previous study about prognostic accuracy of CTA. These patients are constantly under surveillance inside a program promoted by our Unit of Atherosclerosis (Department of Medicine and Medical Specialities) therefore follow-up data are available for all the patients. Electronic data will be reviewed to, firstly, select subjects with CTA positive for carotid arteries stenosis and with a subsequent history of Transient Ischemic Attack (TIA) or Stroke proved by stroke specialist consultant. These patients will constitute the cases group. Then we will build the control group, selecting patients with asymptomatic carotid arteries stenosis proved by CTA; these will be matched for age and gender to the cases group. CTA technique All examinations were carried out using a 64-row CT scanner (Somatom Sensation Cardiac 64; Siemens AG; Erlangen, Germany), with a 64x0.6mm detector configuration, acquiring Coronary CTA followed by Whole-Body CTA as previously described. A highly concentrated iodine contrast medium (Iomeprol-400, Iomeron 400; Bracco, Milan, Italy) was injected at 4mL/s with a double bolus technique (70+50mL; in case of CABG assessment first bolus was of 90-mL due to larger scan range) each one followed by 30 ml saline flush at the same rate. Exclusion criteria were as follow: bpm >90 or irregular hearth rate, contraindications to iodinated contrast medium (congestive heart failure, previous contrast reaction, hypersensitivity to contrast medium or asthma and renal impairment assessed by serum creatinine > 1.5 mg/dl), unstable angina or acute myocardial infarction, pregnancy or breastfeeding and orthopnoea. After patients' selection, studies will be anonymized and the code assigned to each patient will be recorded in a separate database to avoid bias related to knowledge of clinical data. Carotid arteries dataset will be then exported as DICOM files (Digital Imaging and Communications in Medicine). CT Texture Analysis (CTTA) and Data Analysis Texture analysis will be performed using a commercially available software package (TexRAD, TexRAD Ltd, Somerset, UK), a proprietary software algorithm developed and validated by Ganeshan et al. in order to assess heterogeneity. TexRAD uses a filtration-histogram based texture analysis technique to extract pixel size based (fine, medium, coarse) features and quantified histogram parameters including Kurtosis (K), skewness (S) and normalized standard-deviation (SDn). A single operator (a radiologist with a particular interest in vascular imaging) will perform the analysis blinded to the clinical data. A single axial slice will be selected to best represent the bifurcation for each side or the greatest degree of stenosis, in presence of an atherosclerotic plaque. A region of interest (ROI) will be manually delineated which fully enclosed the carotid artery. Texture will be then assessed and results stored in an electronic datasheet. Statistical analysis will be performed using?2, t-test and Mann-Whitney test as appropriate. A p value of < 0.05 will be considered statistically significant for all statistical tests. The statistical analysis will be performed with a dedicated software. References: 1. Naghavi M et al. From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I. Circulation. 2003;108(439): Teng Z et al. Plaque hemorrhage in carotid artery disease: Pathogenesis, clinical and biomechanical considerations. J Biomech. 2014;47(4): Cai J-M et al. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation. 2002;106: DeMarco JK et al. Imaging of high-risk carotid artery plaques: current status and future directions. Neurosurg Focus [Internet]. 2014;36(January):E1. 5. Gupta A et al. Carotid plaque MRI and stroke risk: A systematic review and meta-analysis. Stroke. 2013;44: Saba L et al. Multi-modal CT scanning in the evaluation of cerebrovascular disease patients. Cardiovasc Diagn Ther [Internet]. 2014;4(3): Wintermark M et al. High-resolution CT imaging of carotid artery atherosclerotic plaques. AJNR Am J Neuroradiol. 2008;29(May): Miles K et al. CT texture analysis using the filtration-histogram method: what do the measurements mean? Cancer Imaging [Internet] Jan [cited 2015 Jan 13];13(3): Davnall F et al. Assessment of tumor heterogeneity: an emerging imaging tool for clinical practice? Insights Imaging [Internet] Dec [cited 2014 Nov 20];3(6): Alic L et al. Heterogeneity in DCE-MRI parametric maps: a biomarker for treatment response? Phys Med Biol [Internet] Mar 21 [cited 2014 Dec 27];56(6): Sachdeva J et al. Segmentation, feature extraction, and multiclass brain tumor classification. J Digit Imaging [Internet] Dec [cited 2014 Dec 16];26(6): Rajani NK et al. CT textural analysis of abdominal aortic aneurysms as a biomarker for aneurysm growth. Lancet [Internet]. Elsevier; 2014 Feb [cited 2014 Dec 23];383:S Elenco delle migliori pubblicazioni negli ultimi 5 anni / List of the best publications of the last 5 years H-INDEX e Database di riferimento/h-index and reference Database H-INDEX Database 9 Scopus Pubblicazioni del responsabile della ricerca / Publications of the Principal Investigator (Le pubblicazioni dall'anno 2014 non riportano l'impact factor) nº Descrizione Impact Factor 1. Galea N, Francone M, Zaccagna F, Ciolina F, Cannata D, Algeri E, Agati L, Catalano C, Carbone I (2015). Ultra low-dose of Gadobenate Dimeglumine for late gadolinium enhancement (LGE) imaging in acute myocardial infarction: a feasibility study.. EUROPEAN JOURNAL OF RADIOLOGY, vol. 25, p , ISSN: X 2. F. Zaccagna, M. Anzidei, F. Sandolo, B. Cavallo Marincola, C. Palla, A. Leonardi, G. Caliolo, F. Andreani, V. De Soccio, C. Catalano, A. Napoli (2014). MRgFUS for Liver and Pancreas cancer treatments: The Umberto I Hospital experience. TRANSLATIONAL CANCER RESEARCH, vol. 5,

4 p , ISSN: X 3. Michele Anzidei, R. Argiro, Andrea Porfiri, Fabrizio Boni, Marco Anile, Fulvio Zaccagna, Domenico Vitolo, L. Saba, Alessandro Napoli, A. Leonardi, F. Longo, Federico Venuta, Mario Bezzi, Carlo Catalano (2014). Preliminary clinical experience with a dedicated interventional robotic system for CT-guided biopsies of lung lesions: a comparison with the conventional manual technique. EUROPEAN RADIOLOGY, p.???, ISSN: , doi: /s z 4. Napoli A, Mastantuono M, Cavallo Marincola B, Anzidei M, Zaccagna F, Moreschini O, Passariello R, Catalano C (2013). Osteoid Osteoma: Magnetic Resonance guided Focused Ultrasound for entirely non-invasive treatment.. RADIOLOGY, vol. 267, p , ISSN: Napoli A, Anzidei M, Cavallo Marincola B, Brachetti G, Cartocci G, Marsecano C, Zaccagna F, Marchetti L, Cortesi E, Catalano C (2013). Primary Pain Palliation and Local Tumor Control in Bone Metastases Treated with Magnetic Resonance-guided Focused Ultrasound.. INVESTIGATIVE RADIOLOGY, vol. 48, p , ISSN: Pediconi F, Vasselli F, Roselli A, Zaccagna F, Di Mare L, Catalano C (2012). Unenhanced MRI at 3T in neo-adjuvant chemotherapy. EUROPEAN JOURNAL OF RADIOLOGY, vol. 81, p. S121-S123, ISSN: X 7. Michele Anzidei, Alessandro Napoli, Fulvio Zaccagna, Pier Luigi Di Paolo, L. Saba, Beatrice Cavallo Marincola, Chiara Zini, Gaia Cartocci, Luisa Di Mare, Carlo Catalano, Roberto Passariello (2012). Diagnostic accuracy of colour Doppler ultrasonography, CT angiography and blood-pool-enhanced MR angiography in assessing carotid stenosis: a comparative study with DSA in 170 patients.. LA RADIOLOGIA MEDICA, vol. 117, p , ISSN: , doi: /s Fraioli F, Anzidei M, Zaccagna F, Mennini ML, Serra G, Gori B, Longo F, Catalano C, Passariello R (2011). Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience.. RADIOLOGY, vol. 259, p , ISSN: Michele Anzidei, Alessandro Napoli, Fulvio Zaccagna, Gaia Cartocci, Luca Saba, Guendalina Menichini, Beatrice Cavallo Marincola, Eugenio Marotta, Luisa Di Mare, Carlo Catalano, Roberto Passariello (2011). Liver Metastases From Colorectal Cancer Treated With Conventional and Antiangiogenetic Chemotherapy: Evaluation With Liver Computed Tomography Perfusion and Magnetic Resonance Diffusion-Weighted Imaging. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, vol. 35, p , ISSN: , doi: /rct.0b013e318230d Michele Anzidei, Alessandro Napoli, Fulvio Zaccagna, Beatrice Cavallo Marincola, Chiara Zini, Miles A. Kirchin, Carlo Catalano, Roberto Passariello (2011). First-pass and high-resolution steady-state magnetic resonance angiography of the peripheral arteries with gadobenate dimeglumine: an assessment of feasibility and diagnostic performance.. INVESTIGATIVE RADIOLOGY, vol. 46, p , ISSN: , doi: /rli.0b013e Cristina Neira, Michele Anzidei, Alessandro Napoli, Miles A. Kirchin, B.C. Marincola, Beatrice Cavallo Marincola, Fulvio Zaccagna, Carlo Catalano, Roberto Passariello, Fabio Tedoldi (2011). Investigation of the Longitudinal Relaxation Rate of Blood After Gadobenate Dimeglumine Administration Sequence Optimization, Dynamic Acquisition, and Clinical Impact for Contrast-Enhanced MR Angiography of the Carotid Arteries. INVESTIGATIVE RADIOLOGY, vol. 46, p , ISSN: , doi: /rli.0b013e318227c57c 12. Michele Anzidei, Beatrice Cavallo Marincola, Alessandro Napoli, L. Saba, Fulvio Zaccagna, Pierleone Lucatelli, Fabrizio Fanelli, E. Bassetti, F.M. Salvatori, Carlo Catalano, Roberto Passariello (2011). Low-dose contrast-enhanced time-resolved MR angiography at 3 T: Diagnostic accuracy for treatment planning and follow-up of vascular malformations. CLINICAL RADIOLOGY, vol. 66, p , ISSN: , doi: /j.crad Alessandro Napoli, Michele Anzidei, Fulvio Zaccagna, B.C. Marincola, Beatrice Cavallo Marincola, Chiara Zini, Giulia Brachetti, Gaia Cartocci, Fabrizio Fanelli, Carlo Catalano, Roberto Passariello (2011). Peripheral arterial occlusive disease: diagnostic performance and effect on therapeutic management of 64-section CT angiography.. RADIOLOGY, vol. 261, p , ISSN: , doi: /radiol Arca M, Pigna G, Zaccagna F, Cavallo Marincola B, Montali A, Iuliano L, Napoli A, Catalano C (2010). Atherosclerotic Burden In Asymptomatic Patients With Metabolic Syndrome Evaluated By Computed Tomography Angiography.. ATHEROSCLEROSIS SUPPLEMENTS, vol. 11, ISSN: Michele Anzidei, Alessandro Napoli, Daniel Geiger, B.C. Marincola, Beatrice Cavallo Marincola, Chiara Zini, Fulvio Zaccagna, Pier Luigi Di Paolo, Carlo Catalano, Roberto Passariello (2010). Preliminary experience with MRA in evaluating the degree of carotid stenosis and plaque morphology using high-resolution sequences after gadofosveset trisodium (Vasovist) administration: comparison with CTA and DSA.. LA RADIOLOGIA MEDICA, vol. 115, p , ISSN: , doi: /s y 2,512 1,461 5,726 1,221 4,593 4,593 1,952 5,726 2,064 1,618 Pubblicazioni scientifiche di altri partecipanti alla ricerca / Publications of the other participants (Le pubblicazioni dall'anno 2014 non riportano l'impact factor) nº Descrizione Docente 1. Arca M, Pigna G (2011). Treating the statin-intolerant patients. DIABETES, METABOLIC SYNDROME AND OBESITY, vol. 4, p , ISSN: , doi: /DMSO.S I. Minicocci, S. Santini, V. Cantisani, N. Stitziel, S. Kathiresan, J.a. Arroyo, G. Marti', L. Pisciotta, D. Noto, A.b. Cefalu, Marianna Maranghi, Giancarlo Labbadia, Pigna, F. Pannozzo, Fabrizio Ceci, E. Ciociola, S. Bertolini, S. Calandra, P. Tarugi, M. Averna, Marcello Arca (2013). Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis. JOURNAL OF LIPID RESEARCH, vol. 54, p , ISSN: , doi: /jlr.p Ilenia Minicocci, Vito Cantisani, Eleonora Poggiogalle, Elda Favari, Francesca Zimetti, Anna Montali, Giancarlo Labbadia, Pigna, Fabio Pannozzo, Anna Zannella, Fabrizio Ceci, Ester Ciociola, Sara Santini, Marianna Maranghi, Anna Rita Vestri, Paolo Ricci, Franco Bernini, Marcello Arca (2013). Functional and morphological vascular changes in subjects with familial combined hypolipidemia: An exploratory analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY, vol. 168, p , ISSN: , doi: /j.ijcard Marcello Arca, Elena Salvia, Pigna (2013). Current challenges in the management of patients with familial hypercholesterolemia. CLINICAL LIPIDOLOGY, vol. 8, p , ISSN: , doi: /clp Arca M, Favoccia C, Pigna G (2012). Pathophysiology of diabetic dyslipidemia: implication for atherogenesis.. CURRENT VASCULAR PHARMACOLOGY, vol. 10, p. 1-3, ISSN: I. Minicocci, Anna Montali, M.R. Robciuc, Fabiana Quagliarini, Vincenzo Censi, Giancarlo Labbadia, C. Gabiati, Pigna, M.L. Sepe, F. Pannozzo, D. Lutjohann, S. Fazio, M. Jauhiainen, C. Ehnholm, Marcello Arca (2012). Mutations in the ANGPTL3 gene and familial combined hypolipidemia: A clinical and biochemical characterization. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 97, p. E1266-E1275, ISSN: X, doi: /jc Marcello Arca, Pigna, C. Favoccia (2012). Management of statin-intolerant patient. PANMINERVA MEDICA, vol. 54, p , ISSN: Marcello Arca M, Pigna G (2011). Treating the statin-intolerant patients. DIABETES, METABOLIC SYNDROME AND OBESITY, vol. 4, p , ISSN: , doi: /DMSO.S11244 Marcello Arca, Fabiana Quagliarini, Pigna, Carlo Catalano, Alessandro Napoli (2011). Severe coronary and extracoronary atherosclerosis in autosomal recessive hypercholesterolemia detected by whole-body computed tomography angiography. INTERNAL AND EMERGENCY MEDICINE, vol. 6, p , ISSN: , doi: /s Pigna, Alessandro Napoli, Fulvio Zaccagna, Beatrice Cavallo Marincola, Roberto Monticolo, Carlo Catalano, Luigi Iuliano, Marcello Arca (2011). The relationship between metabolic syndrome, its components, and the whole-body atherosclerotic disease burden as measured by computed tomography angiography. ATHEROSCLEROSIS, vol. 215, p , ISSN: , doi: /j.atherosclerosis

5 4. Richiesta di finanziamento del progetto / Financial request 4.1 Dettaglio richiesta di finanziamento del progetto / Details of the funding request SPESA IN EURO / COST Descrizione / Description Materiale inventariabile (comprese le pubblicazioni da acquisire)/durable Equipments (publications included) 2.000,00 Acquisto computer portatile (MacBook PRO CTO) con software di visualizzazione DICOM (Osirix) e software per l'analisi dei parametri di texture (TexRAD). Materiale di consumo e funzionamento / Materials & Consumables Spese per calcolo ed elaborazione dati / Computing & Data Processing Cost Missioni e partecipazioni a convegni / Travels & participation to conferences & workshops Altro (voce da utilizzare solo in caso di spese non riconducibili alle voci sopraindicate - es. over head) / Other costs 500,00 Elaborazione e trasferimento dati DICOM per successiva processazione con software per l'analisi dei parametri di texture (TexRAD) ,00 Partecipazione ai congressi delle seguenti società di radiologia per la presentazione dei risultati del progetto: Radiological Society of North America, European Society of Radiology, European Society of Neuroradiology, British Society of Neuroradiology e Associazione Italiana di Neuroradiologia. 500,00 Spese di cancelleria; supporti ottici per l'archiviazione delle immagini (DVD); trasferte ed eventuali costi per l'addestramento all'utilizzo dei software; over head vari. TOTALE 4.000,00 Nominativo di uno strutturato (professore/ricercatore) di riferimento Cognome Nome Qualifica Dipartimento CARBONE Iacopo Ricercatore confermato DIP. Scienze radiologiche, oncologiche e anatomo-patologiche iacopo.carbone@uniroma1.it Informazioni aggiuntive/additional information In caso di assegnazione del finanziamento il sottoscritto accetta che titolo della ricerca, abstract e finanziamento assegnato vengano resi pubblici SI Indirizzo del Direttore di Dipartimento Indirizzo del Segratario amministrativo di Dipartimento segmism@uniroma1.it carlo.appetecchia@uniroma1.it Firma... Data 07/05/ :40