2.5. f c 1.5 GVHD GVHD GVHD. day (Anal Chem 2010; 82: ) 2: 14 GVHD. GVHDgrade2 10 GVHD. 1 GVHDgrade CAEBV2

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2 f c GVHD GVHD 1 GVHD day (Anal Chem 2010; 82: ) GVHD GVHD 2: 14 EBV (CAEBV)3 1 2 GVHDgrade GVHDgrade CAEBV2

3 CRP In vitro 2 SDS-PAGE band3 PRDX2 SDS-PAGE Western blot GVHDgrade3 7 6 band3 3 3band3 4PRDX2 20KDa-PRDX2 (5) Band3 1 1 DLI GVHDgrade4 grade0-2 7 CAEBV band3 Band3 6 5, 20KDa TOF-MS 22KDa RPDX2 C Western blot 20KDa 4 PRDX2 5band3 PRDX2 in vitro H2O2 H202 band3

4 PRDX2 K562 hemin H202 PRDX2 K562 band3 band3 DIC/ DIC/ DIC/ practice GVHD (rtm) (Balb/c wild type) (9Gy) (B10D2) GVHD 25 8 GVHD GVHD rtm 3 (0.313mg/kg) 3 2 3mg/kg 6 7 1mg/kg 3 GVHD GVHD 7 rtm10.3mg/kg

5 GVHD 6:Okawa T, Ono T, Endo A, Takagi M, Masayuki Nagasawa. Chronic disseminated candidiasis 12 1:Mitsui-Sekinaka K, Imai K, Sato H, Tomizawa D, Kajiwara M, Nagasawa M, Morio T, Nonoyama S. Clinical features and hematopoietic stem cell transplantation for CD40 ligand deficiency in Japan. Journal of Allergy complicated with a ruptured intracranial fungal aneurysm in ALL. World Journal of Hematology. 2014, 3(2):44-48 DOI: 7:Udagawa T, Motoyoshi Y, Matsumura Y, Takei A, Ariji S, Ito E, ChigaM, Masayuki Nagasawa, Morio T, Mizutani S. Effect of eculizumab and recombinant human soluble thrombomodulin combination therapy in a 7-year-old girl with atypical hemolytic uremic syndrome due to anti- and Clinical Immunology2015 (in press) factor H autoantibodies doi: /j.jaci :Ohkawa T, Sugie M, Tomizawa D, Imai K, Nagasawa M, Morio T, Mizutani S, Takagi M. Transient abnormal myelopoiesis in non-down CEN Case Report 2014; 3: doi: /s :Masayuki Nagasawa, Ohkawa T, Endo A, Mitsuiki N, Ono T, Aoki Y, Isoda T, Tomizawa syndrome neonate. Pediatrics International D, Takagi M, Kajiwara M, Morio T, Mizutani S. 2015; 57: e14-17doi: /ped :Okada H, Maru M, Maeda R, Iwasaki F, Masayuki Nagasawa, Takahashi M. Impact of childhood cancer on maternal employment in Japan. Cancer Nursing 2015; 38(1): doi: /NCC :Nakatani K, Imai K, Shigeno M, Sato H, Tezuka M, Okawa T, Mitsuiki N, Isoda T, Tomizawa D, Takagi M, Nagasawa M, Kajiwara M, Yamamoto M, Arai A, Miura O, Kamae C, Nakagawa N, Honma K, Nonoyama S, Mizutani S, Morio T. Cord blood transplantation is associated with rapid B cell neogenesis compared Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience.international Journal of Hematology 2013 ;98(5): doi: /s :Machida S, Tomizawa D, Tamaichi H, Okawa T, Endo A, Imai K, Nagasawa M, Morio T, Mizutani S, Takagi M. Successful Treatment of Diffuse Large B-Cell Lymphoma in a Patient with bone marrow transplantation Bone With Ataxia Telangiectasia Using Rituximab. Marrow Transplantation 2014, 49: doi: /bmt :Masayuki Nagasawa Ogawa K, Nagata K, Journal of Pediatric Hematology and Oncology 2013; 35(6), doi : /MPH.0b013e d59 Shimizu N. Granulysin and its clinical 10:Isoda T, Mitsuiki N, Ohkawa T, Kaneko S, significance as a biomarker of immune response and NK-cell related neoplasms. World Journal Endo A, Ono T, Aoki Y, Tomizawa D, Kajiwara M, Araki S, Nagasawa M, Morio T, Takagi M, of Hematology ; 3(4): Mizutani S. Irreversible Leukoencephalopathy DOI: /wjh.v3.i4.128 After Reduced-intensity Stem Cell

6 Transplantation in a Dyskeratosis Congenita Patient With TINF2 Mutation. Journal of Thrombomodulin- improves the Pediatric Hematology and Oncology coagulation disorder associated 2013;35(4):e doi: transplantation-related mortality after allogeneic /MPH.0b013e318279e5ca 11:Masayuki Nagasawa, Yuki Aoki A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia Case Reports in Transplantation,. 2012, Article ID , 4 pages, doi: /2012/ :Masayuki Nagasawa Epstein-Barr virus associated B cell lymphoma of recipient origin during the elimination of clonally infected T cells by allogeneic stem cell transplantation Case Reports in Transplantation 2012 doi: /2012/ : :, : : -α : SCT