Ministero della Salute

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1 Ministero della Salute Direzione Generale della Ricerca e dell' Innovazione in Sanità BANDO 2013 PROGRAMMI DI RETE GRADUATORIA PROGETTI PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 13,75 Pediatric ataxias and Public Health : epidemiological studies and disease registry, characterization of genetic determinants and implementation of protocols for diagnosis, management, and rehabilitation using innovative low cost, widely accessible techno Destinatario Istituzionale:Istituto Superiore di Sanita' Pediatric ataxias in Italy: epidemiological studies and disease registry, development of a multi level informatic platform for clinicians and families, and implementation of guidelines for diagnosis, management and care within the National Health System Istituto Superiore di Sanita' Brain Disorders and Neuroscience Improving genetic diagnosis of pediatric ataxias: identification of novel genetic determinants, large scale molecular screenings and genotype phenotype correlates by use of state of the art genomic technologies CASA SOLLIEVO SOFFERENZA Brain Disorders and Neuroscience nella Colonna Pagina 1 di 36

2 Development of innovative low cost, widely accessible technologies for quantitative assessment and home based rehabilitation of motor function in pediatric ataxias OSPEDALE BAMBINO GESU' Brain Disorders and Neuroscience 15, Cognitive and behavioral defects in nonprogressive pediatric ataxias: systematic cognitive profiling, innovative neuroimaging studies and development of low cost, widely accessible technologies for personalized homebased rehabilitation MEDEA Brain Disorders and Neuroscience 13, PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 15,65 Implication for strategies of long term control of viral replication in patient with primary HIV infection (PHI) trated with multitarget antiviral therapy (MT ART): kinetics of viral reservoir, immunological response and drug penetration in lymphoid tissu Destinatario Istituzionale:SAN RAFFAELE MILANO Study of host/virus interactions involved in HIV control, in patient treated with a multitarget antiretroviral (MT ART) therapy during primary HIV infection (PHI). SAN RAFFAELE MILANO Biomedica AIDS and Related Research Virologic evolution in different compartments in patients receiving multitarget antiviral therapy (MT ART) during primary HIV infection (PHI) Lombardia Biomedica AIDS and Related Research nella Colonna Pagina 2 di 36

3 Lymphoid architecture and homeostasis in lymphnodes, gut and peripheral blood in HIV infected patients during primary HIV infection (PHI) and changes upon multitarget antiretroviral therapy (MT ART) Lombardia Biomedica AIDS and Related Research 16, Plasma, intracellular and tissue concentrations reached by a multitarget antiretroviral therapy (MT ART) during the treatment of patients with primary HIV infection (PHI): a pharmacokinetic/pharmacodynamic study Piemonte Biomedica AIDS and Related Research 13, New model of Primary HIV infection (PHI) management: identification of PHI, standardization of antiretroviral treatment and data collection in a nationwide Italian network (INACTION) Lombardia Biomedica AIDS and Related Research 14, PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 17,5 ITALIAN AUTISM SPECTRUM DISORDERS NETWORK: FILLING THE GAPS IN THE NATIONAL HEALTH SYSTEM CARE Destinatario Istituzionale:Istituto Superiore di Sanita' Non invasive tools for early surveillance of at risk populations Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes An integrated specialist web network for early screening of ASD MEDEA Biobehavioral and Behavioral Processes 13, nella Colonna Pagina 3 di 36

4 EARLY BIRD DIAGNOSTIC PROTOCOL FOR AUTISM SPECTRUM DISORDERS (EARLY BIRD) STELLA MARIS Biobehavioral and Behavioral Processes OMICS biomarkers for better care in Autism Spectrum Disorders Lazio Biobehavioral and Behavioral Processes Predictors of outcomes in autism early behavioral intervention OSPEDALE BAMBINO GESU' Biobehavioral and Behavioral Processes PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 17,6 GERIATRIC OUTCOMES AMONG OLDER TYPE 2 DIABETIC PATIENTS TREATED WITH DPP4 INHIBITORS OR GLINIDES (GOOD) Destinatario Istituzionale:I.N.R.C.A Geriatric outcomes among older Type 2 diabetic patients treated with DPP4 inhibitors or glinides: focus on proinflammatory and oxidative stress markers I.N.R.C.A. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Geriatric outcomes among older Type 2 diabetic patients treated with DPP4 inhibitors or glinides: focus on physical functioning Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences Geriatric outcomes among older Type 2 diabetic patients treated with DPP4 inhibitors or glinides: focus on cognitive functioning Campania Endocrinology, Metabolism, Nutrition and Reproductive Sciences nella Colonna Pagina 4 di 36

5 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 18,17 Thalidomide, a novel immunological treatment to modify the natural history of paediatric Crohn's disease: a new proposal from a well established paediatric research network Destinatario Istituzionale:BURLO GAROFALO Thalidomide, a novel immunological treatment to modify the natural history of paediatric Crohn's disease: a new proposal from a well established paediatric research network. BURLO GAROFALO Digestive, Kidney and Urological Systems 18, Genetic and immunological study of children with Crohn's disease receiving thalidomide treatment Lombardia Digestive, Kidney and Urological Systems 19, Evaluation of the effect of pharmacokinetic, metabolomic and pharmacogenomic, profiles of thalidomide on response and toxicity in children with Crohn's disease C.R.O. AVIANO Digestive, Kidney and Urological Systems 16, nella Colonna Pagina 5 di 36

6 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 18,42 Magnetic resonance imaging in drug refractory temporal lobe epilepsy: standardization of advanced structural and functional protocols at 3T, to identify hippocampal and extrahippocampal abnormalities. Destinatario Istituzionale:MONDINO Improved detection of hippocampal and extra hippocampal abnormalities in temporal lobe epilepsy by an advanced MRI 3T protocol, including multiparametric mapping (MPM), diffusion tensor imaging (DTI) and arterial spin labeling (ASL), to assess macrostruct MONDINO Brain Disorders and Neuroscience 17, Surgically treatable temporal lobe epilepsy: in vivo 3T MRI, ex vivo 7T MRI and histological correlations CARLO BESTA Brain Disorders and Neuroscience Brain networks involved in temporal lobe epilepsy as revealed by EEG fmri co registration. A national multi centric study. Emilia Romagna Brain Disorders and Neuroscience 20, nella Colonna Pagina 6 di 36

7 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 18,5 A prospective multicenter study to evaluate the hepatitis C virus (HCV) disease burden in Italy and to assess the clinical and public health impact of the introduction of new direct acting antivirals (DAAs) for the treatment of HCV chronic hepatitis Destinatario Istituzionale:Istituto Superiore di Sanita' Coordination of large national cohorts of patients with chronic HCV infection: data management, monitoring and centralized data analysis. Istituto Superiore di Sanita' Infectious Diseases and Microbiology 18, Strategic use of new DAA combinations in HCV patients with HIV and/or HBV coinfection Lombardia Infectious Diseases and Microbiology Difficult to treat HCV populations in the era of new direct acting antivirals (DAAs) Lazio Infectious Diseases and Microbiology 13, HCV infection in difficult to reach, vulnerable, underserved populations, and gender issues. Emilia Romagna Infectious Diseases and Microbiology 18, Pharmaco economics of the new DAAs for the treatment of chronic HCV infection Sicilia Infectious Diseases and Microbiology nella Colonna Pagina 7 di 36

8 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 18,62 Genomics and metagenomics: use of next generation sequencing (NGS) for cultureindependent detection of pathogens in clinical, food and animal samples and development of a national information system for genomic data to improve the control of foodborne ou Destinatario Istituzionale:Istituto Superiore di Sanita' WP1. Development of metagenomics models for culture independent detection and typing of zoonotic pathogens and study of their interactions with the microbiota in the whole animalto human transmission chain Istituto Superiore di Sanita' Biomedica Veterinary WP2. Development of a next generation sequencing (NGS) based surveillance system enabling multi genome comparisons and improving the control of vector borne viral diseases IZSAM Biomedica Veterinary 20, WP3 Development of a next generation sequencing (NGS) based surveillance system enabling multi genome comparisons for the effective control of infectious diseases at the animal human interface and foodborne zoonoses IZSVE Biomedica Veterinary WP4 Development of a next generation sequencing (NGS) based surveillance system enabling multi genome comparisons and improving the control of diseases caused by protozoa IZSSI Biomedica Veterinary nella Colonna Pagina 8 di 36

9 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 19,1 Characterization of the patient's genome for clinical decision making in hematological malignancies. A personalized medicine program of the Rete Ematologica Lombarda (REL) clinical network. Destinatario Istituzionale:SAN MATTEO Characterization of the patient's genome for clinical decision making in myelodysplastic syndromes (MDS) SAN MATTEO Oncology 2 Translational 18, Prospective evaluation of a KIT adapted treatment of core binding factor leukemia (CBFL) in adults and integrated genetic analysis: a multicenter phase II study Lombardia Oncology 2 Translational 20, Prevalence and clinical significance of c KIT somatic mutations in hypereosinophilic syndromes MAGGIORE Oncology 2 Translational 24, Diffuse large B cell lymphoma (DLBCL) with dysregulation of c myc gene expression. Dissecting the pathological and molecular heterogeneity to support tailored treatment strategies Lombardia Oncology 2 Translational 11, Definition of patient's unique genetic profile to guide therapeutical decision making in myeloproliferative neoplasms (MPN) Lombardia Oncology 2 Translational 20, nella Colonna Pagina 9 di 36

10 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 19,6 Efficacy, feasibility, acceptability and cost effectiveness of different organizational models of Telerehabilitation for chronic neurological patients Destinatario Istituzionale:S.CAMILLO efficacy and cost effectiveness of Telerehabilitation for post Stroke and post Traumatic Brain Injury patients in comparison with usual territorial rehabilitation, analyzed in two different organizational models. S.CAMILLO TELEREHABILITATION IN SEVERE ACQUIRED BRAIN INJURY: IS IT EFFECTIVE? NEUROLESI 16, efficacy of Telerehabilitation on motor and cognitive disorders in Parkinson's disease in comparison with standard rehabilitation MONDINO 21, Blind assessment of outcome measures in Telerehabilitation for neurological patients and caregivers' burden, and contribution to a randomised noninferiority clinical trial on patients with sequelae of Stroke CARLO BESTA Health Technology Assessment of Istituto Superiore di Sanita' different care models in telerehabilitation 21, nella Colonna Pagina 10 di 36

11 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 19,67 Obesity comorbidities in childhood: a multidisciplinary approach to investigate the mechanisms involved and new targets for treatment Destinatario Istituzionale:Piemonte A translational approach to investigate the biomolecular role of Vitamin D in pediatric obesity and insulin resistance Piemonte Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Micro RNA Regulation: Understanding, predicting, diagnosing and treatingnafld and obesity related complications in Childhood Emilia Romagna Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences Effects of perfluorinated chemicals (PFCs) levels on growth and insulin resistance inneonates born with adequate or low weight for gestational age Emilia Romagna Biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 20,1 Latent infections, subclinical communicable diseases and relevant immunological profile in immigrants from high endemic areas to Italy Destinatario Istituzionale:Istituto Superiore di Sanita' nella Colonna Pagina 11 di 36

12 Novel approaches to the diagnosis of subclinical, unapparent or latent socially relevant infectious diseases in immigrants in Italy and identification of prognostic indexes based on the specific immune response signature Istituto Superiore di Sanita' Infectious Diseases and Microbiology Assessment of the prevalence, clinical and virological characteristics of Viral Hepatitis in immigrants through the implementation of different screening and prevention adjusted to social environment Lombardia Infectious Diseases and Microbiology 19, Implementation of diagnostic method for diagnosis of tuberculosis in recently immigrants from TB high endemic area Lazio Infectious Diseases and Microbiology 21, Screening for infectious diseases in recent migrants and evaluation of the specific immune responses for diagnosis driven treatment and prevention strategies. Calabria Infectious Diseases and Microbiology 19, Screening for clinically unapparent infectious diseases at high social impact in recently immigrants from Africa for early diagnosis and appropriate treatment Puglia Infectious Diseases and Microbiology nella Colonna Pagina 12 di 36

13 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 20,5 GOOD TRANSITION. INVESTIGATING MODELS OF TRANSITION FROM CHILDHOOD TO ADULTHOOD IN MAJOR GENETIC, NEUROLOGICAL, AND PSYCHIATRIC DISORDERS: A MULTIMODAL STUDY COMBINING PSYCHOSOCIAL, COGNITIVE AND BIOLOGICAL VARIABLES Destinatario Istituzionale:MEDEA Improving Transition Process in major psychoses MEDEA 15, Transition in Cystic Fibrosis: comparing management models to improve quality of care OSPEDALE BAMBINO GESU' 30, Improving Transition Process in severe Myopathies GASLINI Psychosocial and biological factors influencing the transition from adolescence to early adulthood Istituto Superiore di Sanita' Improving transition for autism spectrum disorders Lombardia 20, nella Colonna Pagina 13 di 36

14 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 20,5 Cerebral Cavernous Malformations: from clinic to disease mechanisms toward prevention and treatment Destinatario Istituzionale:Lombardia Cerebral Cavernous Malformations: from clinic to disease mechanisms toward prevention and treatment Lombardia Brain Disorders and Neuroscience 19, Cerebral Cavernous Malformations: from clinic to disease mechanisms toward prevention and treatment Piemonte Brain Disorders and Neuroscience 18, Cerebral Cavernous Malformations: from clinic to disease mechanisms toward prevention and treatment Toscana Brain Disorders and Neuroscience Cerebral Cavernous Malformations: from clinic to disease mechanisms toward prevention and treatment Veneto Brain Disorders and Neuroscience 24, Cerebral Cavernous Malformations: from clinic to disease mechanisms toward prevention and treatment Abruzzo Brain Disorders and Neuroscience 17, nella Colonna Pagina 14 di 36

15 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 21,31 Hypothesis driven precision medicine for ovarian cancer using patient derived xenografts (PDXs). Destinatario Istituzionale:Piemonte Human mouse co clinical trials to tailor chemotherapy for ovarian cancer Piemonte Biomedica Oncology 2 Translational 21, Identification of a panel of biomarkers able to predict response to bevacizumab in women with advanced high grade serous ovarian cancer receiving neoadjuvant chemotherapy Lazio Biomedica Oncology 2 Translational Targeted therapy in ovarian cancer with novel anti angiogenic and anti PARP drug combinations: efficacy and predictive biomarkers I.E.O. Biomedica Oncology 2 Translational XENO PATIENTS co clinical trial to validate novel treatment modalities in ovarian cancer MARIO NEGRI Biomedica Oncology 2 Translational nella Colonna Pagina 15 di 36

16 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 21,5 Identification and validation of methods and markers to identify and follow up Chronic Myeloid Leukemia (CML) patients who are potential candidates to discontinue Tyrosine Kinase Inhibitors (TKI) therapy with minimal risk of disease recurrence Destinatario Istituzionale:Piemonte Molecular markers and innovative technologies predictive of succesful treatment discontinuation in CML patients receiving tyrosine kinase inhibitors Piemonte Oncology 2 Translational 13, Profile of Bone Marrow microenvironment biological markers in CML patients treated with TKIs: development a novel diagnostic tools Campania Oncology 2 Translational 21, Optimization of TKIs Multiple Approaches and quality of life (QoL) in elderly patients (60 years of age or older) with Ph+ chronic myeloid leukemia (CML) and MR3.0 / MR4.0 stable molecular response Lombardia Oncology 2 Translational 26, High resolution genomic and metabolic characterization of leukemia stem cells to predict successful treatment discontinuation in chronic myeloid leukemia patients Emilia Romagna Oncology 2 Translational 24, nella Colonna Pagina 16 di 36

17 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 22,55 Validation and applications of new integrated viro immunologic strategies for the diagnosis, monitoring and pre symptomatic treatment of CMV and EBV infections in stem cell transplant recipients. Destinatario Istituzionale:Emilia Romagna Standardizing virological methods for the diagnosis, monitoring and presymptomatic treatment of CMV and EBV infections in adult and pediatric stem cell transplant recipients. Emilia Romagna Infectious Diseases and Microbiology 19, surveillance models and viral DNA cut off for pre symptomatic treatment of CMV and EBV infections in adult high risk stem cells transplant recipients. Lombardia Infectious Diseases and Microbiology surveillance models and viral DNA cut off for pre symptomatic treatment of CMV and EBV infections in pediatric stem cells transplant recipients SAN MATTEO Infectious Diseases and Microbiology surveillance models and viral DNA cut off for pre symptomatic treatment of CMV and EBV infections in adult and pediatric low risk stem cells transplant recipients. Lazio Infectious Diseases and Microbiology 24, nella Colonna Pagina 17 di 36

18 Evaluation of CMV and EBV specific cellular immune responses in hematopoietic stem cell transplant recipients to prevent and control viral infection. Piemonte Infectious Diseases and Microbiology 21, PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 22,6 Optimal management of patients with chronic heart failure complicated by co morbidities by home monitor and support: scientific, medical,social and economic benefits. Destinatario Istituzionale:Toscana Home monitoring of the atrial fibrillation burden. Toscana Metabolic and cardiac home monitoring in complicated heart failure/diabetic patients. MULTIMEDICA Strategies to manage patients with chronic obstructive lung diseases and heart failure at home. Toscana 13, Preventing Heart Failure progression by home monitor and support at an early stage. Campania 28, Preventing Heart Failure progression by home monitor and support at an early stage. Lombardia nella Colonna Pagina 18 di 36

19 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 22,9 Investigation of health services organization within a neonatal and perinatal network: evaluation of fetal antecedents and neuroprotection on neonatal and infant brain injury, neurodevelopmental delay and growth. A model to predict infant outcomes and pro Destinatario Istituzionale:Lombardia Modeling current perinatal and neonatal data to predict infant outcomes and provide tools for measuring and improving quality of care Lombardia 32, Magnesium Sulphate to prevent neurologic damage following preterm birth Lombardia 22, Ultrasound accuracy in assessing cerebellar haemorrhages in Very Low Birth Weight infants Liguria 18, Area based Emilia Romagna Neonatal Network: outcome of VLBW infants at two years Emilia Romagna 21, Prospective longitudinal approach to the small fetus: how different patterns of fetal growth impact on neonatal morbidity and auxological, neurodevelopmental and metabolic outcomes at 2 years of corrected age. Piemonte 19, nella Colonna Pagina 19 di 36

20 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 22,93 An integrated approach for prevention and early diagnosis of brain damage in a multiethnic pediatric population with sickle cell disease. Determinants of cognitive impairment in relationship to clinical and hematological markers of disease severity Destinatario Istituzionale:Veneto Development and standardization of a Cognitive evoked potentials and Low resolution computed tomography (LORETA) protocol in children with SCD and in age ethnic matched controls Veneto Vascular and Hematology 21, Development and standardization of a Neuro Cognitive Protocol to evaluate monolingual and bilingual infants, preschool and school age children with Sickle Cell Disease Emilia Romagna Vascular and Hematology 22, Development and standardization of a Sleep study questionnaire and Polysomnography protocol in a multiethnic population of children with Sickle Cell Disease Lombardia Vascular and Hematology Development and standardization of a MRI/MRA, Functional MRI protocol since young age in a multiethnic population of children with Sickle Cell Disease Campania Vascular and Hematology 21, nella Colonna Pagina 20 di 36

21 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 22,95 Telepathology in oncology: a national network in connection with the Sicily region. Destinatario Istituzionale:NEUROLESI Implement technical architecture, data flow organization and security control systems to extend the regional telepathology network to a national environment. NEUROLESI A project for establishing a telepathology service for Anatomic Pathology using whole slide imaging. C.R.O. AVIANO 18, A project aimed to establish/implement a telepathology network and service in selected Anatomic Pathology subspecialties REGINA ELENA 22, Campania Thelepathology Network : focus on colorectal and skin tumors immunoscore. PASCALE 26, Whole slide imaging telepathology in pediatric tumors and soft tissue sarcomas diagnosis. Whole slideimaging telepathology applicability to in situ molecular pathology ISTITUTO TUMORI MILANO nella Colonna Pagina 21 di 36

22 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 23,25 LIBRA TRIAL: LIFESTYLE INTERVENTIONS IN EARLY BREAST CANCER PATIENTS Destinatario Istituzionale:Liguria Feasibility and effects on body composition of a life style intervention with diet and exercise in early breast cancer (BC) patients. Liguria Biomedica Oncology 2 Translational 27, Development of a clinical algorithm for a dynamic prognosistic assessment in patients with early breast cancer entered in a lifestyle modifying intervention program IRCCS AOU San Martino IST (Genova) Biomedica Oncology 2 Translational Impact of a radical lifestyle intervention in early breast cancer on the level of expression of selected circulating mirna known to be related to BC prognosis Istituto Scientifico Romagnolo Biomedica Oncology 2 Translational 19, Evaluation of the impact on patient metabolism of a lifestyle intervention, including Mediterranean Diet and Physical activity in early breast cancer (BC) patients. Toscana Biomedica Oncology 2 Translational nella Colonna Pagina 22 di 36

23 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 23,37 Mental Health Goes to Coproduction: Developing, Implementing and Evaluating Interventions at Individual, Organisational and System Level. Destinatario Istituzionale:Lombardia Pathways to Recovery from Mental Illness. From rehabilitation to education and self management: the Recovery College Model.A study to evaluate the impact of the partecipation to training groups based on the Recovery Capital approach on individual pathway Lombardia 34, The role of Users and Family Members in Peer Support.A study to assess methods and practices of users involvement in mental health services delivery and its impact on treatment outcomes, on the culture of the service workforce and stakeholders of local c Provincia autonoma Trento 27, Supporting Organisations towards Coproduction and Recovery: a peeraccreditation process among all the relevant stakeholders in the mental health field to design, test and implement an instrument to assess, monitor and support organisations that choose c Emilia Romagna nella Colonna Pagina 23 di 36

24 Personalisation in Mental Health. A qualitative research on promising and best practices to promote personalisation in mental health care plans and on the implementation and evaluation of innovative interventions across the sites of the Project. Friuli Venezia Giulia 31, Individualized Care Plans (ICPs): Users and their carers in the "driver's seat".a study to compare the outcomes of ICPs coproduced by users, their carers with mental health services key workers vs standard ICPs based on the preminence of professionals. Piemonte PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 24,17 The optimization of the acute stroke pathway: from planning to territorial activity Destinatario Istituzionale:Lombardia The emergency urgency network rationalization and the development of a disease management manual Lombardia The Hub and Spoke process for the endovascular treatment of acute ischaemic stroke Friuli Venezia Giulia 31, The use of telestroke system to improve acute stroke care Veneto nella Colonna Pagina 24 di 36

25 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 24,87 An integrated approach for Breast Cancer prevention and risk reduction in the general female population invited to breast cancer screening programmes, in high risk group and in treated patients. Destinatario Istituzionale:Toscana A sustainable strategy for the prevention of recurrences and risk reduction in breast cancer patients based on permanent life style modifications: a randomized intervention trial to evaluate a one year protocol aimed to obtain dietary and physical activit Toscana Biomedica Population Sciences and Epidemiology 27, Evaluation of the clinical performance of Digital Breast Tomosynthesis (DBT) as a primary test for breast cancer screening: a multicentre randomized trial Piemonte Biomedica Population Sciences and Epidemiology Identification of a tailored protocol and a risk reduction strategy for breast cancer in affected and unaffected BRCA1/2 carriers and in familial breast cancer high risk subjects Evaluation of the feasibility of the protocol in different areas in the Toscana Biomedica Population Sciences and Epidemiology 27, Digital breast tomosynthesis as a primary test for breast cancer screening: assessment of safety, accuracy, costeffectiveness and organizational impact. Emilia Romagna Biomedica Population Sciences and Epidemiology 27, nella Colonna Pagina 25 di 36

26 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 25,5 Increased risk of colorectal cancer (CRC) development: epidemiological, clinical and molecular characterization of synchronous, metachronous and juvenile cancers. An Italian task force. Destinatario Istituzionale:HUMANITAS Clonal composition of synchronous colorectal tumors to address field effect(s) theory. HUMANITAS Biomedica Oncology 2 Translational 22, Epigenetic profiles of early onset, synchronous and metachronous colorectal cancers. Emilia Romagna Biomedica Oncology 2 Translational NGS based genomic profiling of synchronous and metachronous tumors arising in patients with attenuated polyposis C.R.O. AVIANO Biomedica Oncology 2 Translational 18, Epidemiological, clinical and molecular characterization of juvenile CRC. REGINA ELENA Biomedica Oncology 2 Translational 23, MicroRNA expression profiles as predictors of colorectal cancer predisposition Lazio Biomedica Oncology 2 Translational nella Colonna Pagina 26 di 36

27 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 26,62 validation of appropriateness and suitability of Magnetoencephalography (MEG) in selected neurological disorders. Improvement diagnosis and patient management/treatment. Destinatario Istituzionale:CARLO BESTA added value of MEG in surgical planning and patients management and outcome in patients who will undergo to brain surgery for low grade brain tumors, vascular malformations or epilepsy CARLO BESTA 19, Evaluation of the cost benefit ratio of Magnetoencephalography (MEG) to optimize selection of Stroke and Mild Cognitive Impairment patients requiring early, intensive and prolonged rehabilitation. S.CAMILLO 28, Application of high density EEG and fmri in epilepsy and neurorehabilitation Veneto 22, Impact of Magnetoencaphalography in the diagnosis and follow up of schizophrenic patients Abruzzo 35, nella Colonna Pagina 27 di 36

28 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 28 ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: COMPARATIVE ANALYSIS OF CUMULATIVE INCIDENCE OF PREMATURITY RELATED DISEASES BETWEEN PATIENTS RECEIVING CORD BLOOD OR ADULT BLOOD TRANS Destinatario Istituzionale:Lazio ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD UNITS IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: COMPARATIVE ANALYSIS OF CUMULATIVE INCIDENCE OF PREMATURITY RELATED DISEASES BETWEEN PATIENTS RECEIVING CORD BLOOD OR ADULT BLOOD Lazio Vascular and Hematology ALLOGENEIC TRANSFUSION OF RED BLOOD CELL (RBC) CONCENTRATES FROM CORD BLOOD IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS: MICROPARTICLE CHARACTERIZATION IN CORD BLOOD AND ADULT DONOR RBC UNITS. CASA SOLLIEVO SOFFERENZA Vascular and Hematology nella Colonna Pagina 28 di 36

29 ALLOGENEIC TRANSFUSION OF Abruzzo CORD BLOOD RED BLOOD CELL (RBC) CONCENTRATES IN EXTREMELY LOW BIRTH WEIGHT NEONATES: COMPARISON OF IMMUNOMODULATION AND EFFECT ON LYMPHOCYTE SUBSETS EXERTED BY CORD BLOOD OR ADULT BLOOD PRODUCTS. Vascular and Hematology ALLOGENEIC TRANSFUSION OF RED BLOOD CELL CONCENTRATES FROM CORD BLOOD UNITS IN EXTREMELY LOW BIRTH WEIGHT PRETERM INFANTS. Calabria Vascular and Hematology PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 28,06 Population health in contaminated sites, with a focus on children Destinatario Istituzionale:Istituto Superiore di Sanita' Epidemiological surveillance in contaminated sites: improvements in study design and implementation of SENTIERI KIDS Project Istituto Superiore di Sanita' Biomedica Population Sciences and Epidemiology Cancer incidence in contaminated sites, with a focus on children Toscana Biomedica Population Sciences and Epidemiology 30, nella Colonna Pagina 29 di 36

30 Individual based cohort studies on air quality and cardiorespiratory diseases in industrial sites: indicators for public health policy Lazio Biomedica Population Sciences and Epidemiology 27, Environment related diseases in contaminated sites: the response of health services Piemonte Biomedica Population Sciences and Epidemiology 30, PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 28,13 Transition from standard genetic testing into genomic technology: assessment of organizational and economic impact of new diagnostic tools onto health system. Destinatario Istituzionale:Liguria New emerging technologies and their translational application to genomic medicine: genetic laboratories automation, from Sanger sequencing to targeted NGS chip design for the molecular diagnosis of genetic disease, cost analysis using ABC model for an app Liguria Genes, Genomes and Genetics 28, Certification, quality and cost analysis of genetic testing, and assessment of genetic counselling offered by genetic services. National survey and international data base connections. OSPEDALE BAMBINO GESU' Genes, Genomes and Genetics 31, nella Colonna Pagina 30 di 36

31 Cost analysis plan of new genomic technologies using different operative models for an efficient benchmarking and appropriate allocation of NHS recourses. RIZZOLI Genes, Genomes and Genetics 24, The clinical risk management in Medical Genetics Piemonte Genes, Genomes and Genetics PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 28,5 Prenatal and early post natal determinants of common acute and chronic health problems in childhood: the Piccolipiù birth cohort and the network of Pediatric Hospitals Destinatario Istituzionale:Toscana Perinatal factors associated with respiratory infections and their sequelae: the Piccolipiù birth cohort and the network of Pediatric Hospitals Toscana Population Sciences and Epidemiology 23, Air pollution exposure, socioeconomic BURLO GAROFALO characteristics of the family, perinatal maternal psychological distress and child neurodevelopment: the Piccolipiù birth cohort and the network of Pediatric Hospitals Population Sciences and Epidemiology 33, Early risk factors of overweight and obesity in young children: the Piccolipiù birth cohort and the network of Pediatric Hospitals Lazio Population Sciences and Epidemiology nella Colonna Pagina 31 di 36

32 Early epigenetic markers of childhood diseases: the Piccolipiù birth cohort and the network of Pediatric Hospitals Piemonte Population Sciences and Epidemiology 21, Communication strategies to parents for evidence based preventive practices in childhood: the Piccolipiù birth cohort and the network of Pediatric Hospitals OSPEDALE BAMBINO GESU' Population Sciences and Epidemiology 34, PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 29,05 Multiparametric prognostic approach in chronic heart failure. A prospective validation of the MECKI (Metabolic Exercise data combined with Cardiac Kidney Index) score. Destinatario Istituzionale:MONZINO INFLUENCE OF DIFFERENT BETABLOCKERS ON HEART FAILURE PROGNOSIS. A PROSPECTIVE ANALISYS MONZINO Cardiovascular and Respiratory Sciences 26, Breathing pattern during sleep and wakefulness in congestive heart failure patients AUXOLOGICO Cardiovascular and Respiratory Sciences 30, Evaluation of prognostic accuracy of a multi marker model including MECKI score and several cardiac risk biomarkers according to the principles of Evidence Based Laboratory Medicine and International Recommended Criteria Toscana Cardiovascular and Respiratory Sciences nella Colonna Pagina 32 di 36

33 ROLE OF RESTING AND EXRECISE CHRONOTROPIC VARIABLES IN THE PROGNOSIS OF PATIENTS AFFECTED BY HEART FAILURE: NEW INSIGHTS OF THE MECKI SCORE Campania Cardiovascular and Respiratory Sciences 23, A prospective validation of MECKI score in idiopathic dilated cardiomyopathy: is it time for improving the prognostic stratification of this rare disease? Friuli Venezia Giulia Cardiovascular and Respiratory Sciences PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 29,16 Defining a new diagnostic and prognostic biomarkers tool in low risk prostate cancer management. Destinatario Istituzionale:PASCALE Defining a new diagnostic and prognostic biomarkers tool in low risk prostate cancermanagement. PASCALE Oncology 2 Translational Defining a new diagnostic and prognostic biomarkers tool in low risk prostate cancermanagement. Piemonte Oncology 2 Translational 15, Defining a new diagnostic and prognostic biomarkers tool in low risk prostate cancermanagement. Calabria Oncology 2 Translational nella Colonna Pagina 33 di 36

34 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 29,56 Fecal Microbiota Transplantation (FMT) program: Realization of regional referral centers for the treatment of recurrent Clostridium difficile infection by FMT. Destinatario Istituzionale:Lazio Fecal Microbiota Transplantation (FMT) program: Realization of regional referral centers for the treatment of recurrent Clostridium difficile infection by FMT. Lazio Fecal Microbiota Transplantation (FMT) program: Realization of regional referral centers for the treatment of recurrent Clostridium diffcile infection by FMT. Emilia Romagna Fecal Microbiota Transplantation (FMT) program: Realization of regional referral centers for the treatment of recurrent Clostridium diffcile infection by FMT. Lombardia 27, Fecal Microbiota Transplantation (FMT) program: Realization of regional referral centers for the treatment of recurrent Clostridium diffcile infection by FMT. Abruzzo nella Colonna Pagina 34 di 36

35 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 29,75 Diabetes and obesity as a rising risk factor for metabolic chronic liver disease and Hepatocellular Carcinoma (HCC): a gender oriented region wide study. Destinatario Istituzionale:Emilia Romagna Gender oriented molecular characterization of Hepatocellular Carcinoma (HCC) associated with Diabetes and Obesity: impact on clinical aggressiveness and survival. Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences 28, Active screening for chronic liver disease and HCC in diabetics and genderoriented epidemiology via the RER Diabetes Care Net Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences Comparative imaging and locoregional treatment outcome in diabetes/nash vs. viral HCCs ARCISPEDALE Endocrinology, Metabolism, Nutrition and Reproductive Sciences 37, Gender burden assessment in development, progression, therapy and self management of diabetes, obesity and related conditions Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences 29, nella Colonna Pagina 35 di 36

36 PROGRAMMA NETWORK CODICE: SCORE MEDIO DEL NETWORK: 33,83 Dynamic MR imaging of the pelvic floor functional disorders: a comparison between sitting and supine position. Destinatario Istituzionale:Sicilia Dynamic MR imaging of the pelvic floor functional disorders: a comparison between sitting and supine position. Sicilia Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering 35, Dynamic MR imaging of the pelvic floor functional disorders: a comparison between sitting and supine position. Campania Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering 30, Dynamic MR imaging of the pelvic floor functional disorders: a comparison between sitting and supine position. Lazio Biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering 35, nella Colonna Pagina 36 di 36