ELENCO DELLE PUBBLICAZIONI LIBRI

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1 ELENCO DELLE PUBBLICAZIONI LIBRI - Roberto Federico Villa Elena Arrigoni - Farmacologia Generale (Anno 1993) - Edizioni La Goliardica Pavese - Roberto Federico Villa - Principi di Farmacologia Generale (Anno 1993, I Edizione; Anno 1996, II Edizione) - Edizioni La Goliardica Pavese - Roberto Federico Villa Antonella Gorini - Principi di Farmacologia Generale (Anno 2004, I Edizione; Anno 2007, II Edizione, Anno 2011, III Edizione) - Edizioni La Goliardica Pavese - Roberto Federico Villa - Molecular Pharmacology (Monografia Edita nell Anno 2010, I Edizione) - Roberto Federico Villa Antonella Gorini - Principi di Farmacologia Generale (Anno 2013, I Edizione, Anno 2015 II Edizione) - Edizioni Medea, Pavia PARTE I. PUBBLICAZIONI SPERIMENTALI EDITE SU RIVISTE SCIENTIFICHE NAZIONALI ED INTERNAZIONALI 1) Villa RF, Panceri P. Action of some drugs on performance time in mice. Il Farmaco Ed. Pr., 28, (1973). 2) Benzi G, Arrigoni E, Panceri P.Villa RF, D'Angelo L, Panzarasa R, Autelli M, Bertè, F. Action of some antispasmodics on gastrointestinal muscle. Digestion, 11, (1974). 3) Villa RF, Benzi G. Drugs and muscular pathways of pyruvate metabolism adapted to endurance training. Il Farmaco Ed. Pr., 30, (1975). 4) Benzi G, Panceri P, De Bernardi M., Villa RF, Arcelli E., D'Angelo L., Arrigoni E, Bertè F. Mitochondrial enzymatic adaptation of skeletal muscle to endurance training. J. Appl. Physiol., 38, (1975). 5) Villa RF. Effect of hypoxia on the cerebral energy state. Il Farmaco Ed. Pr., 30, (1975). 6) Benzi G, Villa RF. Adenyl cyclase system and cerebral energy state. J. Neurol. Neurosurg. Psych., 39, (1976). 7) Benzi G, Villa RF, Pastoris O, Arrigoni E, Strada P, Ogliari M., Montani A. Drugs and brain mitochondrial enzymatic activities during post-natal development in rat. Il Farmaco Ed. Pr., 31, (1976). 8) Benzi G, Arrigoni E, Pastoris O, Villa RF. Muscle metabolism investigated at rest and during exercise and/or pharmacological treatment by vasodilators. li Farmaco Ed. Pr., 31, 3-20 (1976). 9) Villa RF, Strada P, Barbieri G. A comparative study on some mitochondrial enzymes from rat brain. Il Farmaco Ed. Pr., 32, (1977). 10) Benzi G, Villa RF, Montani A., Pastoris O, Arcelli E, Strada P, Arrigoni E. Influence of training and pharmacological treatment on muscular enzymatic activities. J. Pharm. Sci., 66, (1977). 11) Benzi G, Arrigoni E, Strada P, Pastoris O, Villa RF, Agnoli A. Metabolism and cerebral energy state: effect of acute hyperammonemia in beagle dog. Biochem. Pharmacol., 26, (1977). 12) Benzi G, Arrigoni E, Villa RF, Agnoli A. Effect of acute hyperammoniemia on metabolism and cerebral energy state. Monogr. Gesamtgeb. Psychiatr. Psychiatry Ser., 18, (1978). 13) Villa RF, Strada P, Dagani F, Benzi G. Magnification of some enzymatic activities of brain cortex subfractions. Biochem. Pharmacol., 27, (1978).

2 14) Villa RF, Strada P, Marzatico F, Dagani F, Effect of (-)eburnamonine, papaverine and UDP-glucose on cerebral energy state during and after experimental hypoxia and ischemia in beagle dog. Eur. Neurol., 17, (1978). 15) Benzi G, Villa RF, Arrigoni E, Agnoli A. Cerebral energy status and the acute hyperammoniemia syndrome: interference of S-adenosyl-L-methionine and adenosine. Minerva Med., 69, (1978). 16) Benzi G, Arrigoni E, Dagani F, Pastoris O, Villa RF, Agnoli A. Cerebral energy state during or after hypoxia and complete or incomplete ischemia. J. Appl. Physiol., 45, (1978). 17) Benzi G, Arrigoni E, Dagani F, Marzatico F, Manzini A., Pastoris O, Villa RF. Drug action on cerebral energy state during and after various hypoxic conditions. Arch. Int. Pharmacodyn. Therap., 236, (1978). 18) Benzi G, Arrigoni E, Strada P, Villa RF. Enzymatic activities in the senescent brain and interference with S-adenosyl-L-methionine. Exp. Geront., 14, (1979). 19) Benzi G, Arrigoni E, Pastoris O, Villa RF, Dagani F, Marzatico F, Agnoli A. Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia. Biochem. Pharmacol., 28, (1979). 20) Arrigoni E, Benzi G, Dagani F, Falconi G., Mandelli V., Moretti A., Scelsi R., Villa RF. Zerebrale Enzymatische Activitatin Verbindung mit Energieumwandlungsprozessen. Arzneim. Forsch. (Drug Res.), 29, (1979). 21) Benzi G, Arrigoni E, Dagani F, Carini L., Curti D, Villa RF. S-adenosyl-L-methionine, related compounds and cerebral enzymatic activities during chronic hyperammonemia in rats. Toxicol. Appl. Pharmacol., 48, (1979). 22) Benzi G, Arrigoni E, Marzatico F, Villa RF- Influence of some biological pyrimidines on the succinate cycle during and after cerebral ischemia. Biochem. Pharmacol., 28, (1979). 23) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Manzini A., Villa RF. Effect of chronic treatment with some drugs on the enzymatic activities of the rat brain. Biochem. Pharmacol, 28, (1979). 24) Benzi G, Agnoli A., Dagani F, Ruggieri S., Villa RF. Effect of phenobarbital on cerebral energy state and metabolism. Stroke, 10, (1979). 25) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Raimondo S., Dossena M., Polgatti M., Villa RF. Age dependent modifications of drug interference on the enzymatic activities of the rat brain. Exp. Geront., 15, (1980). 26) Benzi G, Arrigoni E, Scelsi R., Marzatico F, Gorini A., Villa RF. Acetylcholinesterase sensitivity to chronic administration of diphenylhydantoin and effects on cerebral enzymatic activities related to energy metabolism. Neurochem. Res., 5, (1980). 27) Benzi G, Arrigoni E, Marzatico F, Pastoris O, Polgatti M., Villa RF. Effect of alphaxalone-alphadolone on some enzymatic activities from rat brain. Il Farmaco Ed. Pr., 35, (1980). 28) Benzi G, Arrigoni E, Pastoris O, Raimondo S., Dossena M, Fulle D., Tuminello MC, Villa RF. Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery. Arch. Int. Pharmacodyn. Therap., 247, (1980). 29) Villa RF. Brain enzymes and ischemia. Eur. Neurol., 20, (1981). 30) Benzi G, Arrigoni E, Pastoris O, Raimondo S, FULLE, D., Curti D, Villa RF. Metabolic changes induced by acute hypoxia on the synaptosomes from dog brain. Eur. Neurol., 20, (1981). 31) Villa RF, Raimondo S, Curti D. Cerebral enzymatic activities during chronic hyperammonemia and treatment with S-adenosyl-L-methionine in rat. Il Farmaco Ed. Pr., 36, (1981).

3 32) Benzi G, Arrigoni E, Pastoris O, Raimondo S, Fulle D., Villa RF. Phenobarbital interference on cerebral metabolism related to energy transduction. Il Farmaco Ed. Pr., 36, (1981). 33) Benzi G, Arrigoni E, Pastoris O, Marzatico F, Curti D, Piacenza G., Villa RF. Effect of vincamine on some enzymatic activities from various areas of the beagle dog cerebral cortex. Il Farmaco Ed. Pr., 36, (1981). 34) Villa RF, Benzi G, Curti D. The effect of ischemia and pharmacological treatment evaluated on synaptosomes and purified mitochondria from rat cerebral cortex. Biochem. Pharmacol., 30, (1981). 35) Curti D, Marzatico F, Dagani F, Villa RF, Benzi G. Effect of ischemia and pharmacological treatment on subcellular fractions from neonatal rat brain. Il Farmaco Ed. Pr., 37, (1982). 36) Villa RF, Curti D, Polgatti M, Benzi G. Synaptosomes and mitochondria from rat brain cerebral cortex. In vivo interference on some enzymatic activities by SAMe and CDP-choline. J. Neurosc. Res., 7, (1982). 37) Benzi G, Arrigoni E, Agnoli A., Raimondo S, Fulle D, Pastoris O, Curti D, Villa RF. Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain. Exp. Geront., 17, (1982). 38) Benzi G, Arrigoni E, Pastoris O, Villa RF, Dossena M, Agnoli A, Giuffrida AM. Drug action on the metabolic changes induced by acute hypoxia on synaptosomes from the cerebral cortex. J. Cereb. Blood Flow Metabol., 2, (1982). 39) Dagani F, Gorini A, Polgatti M, Villa RF, Benzi G. Rat cortex synaptic and nonsynaptic mitochondria: enzymatic characterization and pharmacological effects of naftidrofuryl. J. Neurosci. Res., 10, (1983). 40) Villa RF, Marzatico F, Benzi G. Changes induced by ischemia on some cerebral enzymatic activities related to energy transduction and amino acids metabolism. Neurochem. Res., 8, (1983). 41) Gorini A, Villa RF. Action of dihydroergocristine on enzyme activities related to energy transduction. Il Farmaco Ed. Pr., 38, (1983). 42) Dagani F, Gorini A, Polgatti M, Villa RF, Benzi G. Synaptic and non-synaptic mitochondria from rat cerebral cortex. Characterization and effect of pharmacological treatment on some enzyme activities related to energy transduction. Il Farmaco Ed. Pr., 38, (1983). 43) Villa RF, Gorini A. Effect of ischemia and pharmacological treatment on enzyme activities of cortical mitochondria and synaptosomes. Int. J. Clin. Pharm. Res., 4, (1984). 44) Benzi G, Pastoris O, Villa RF, Giuffrida, AM. Effect of aging on cerebral cortex energy metabolism in hypoglycemia and posthypoglicemic recovery. Neurobiol. Aging, 5, (1984). 45) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Pastoris O. Cerebral and cerebellar metabolic changes induced by drugs during the recovery period after profound hypoglycemia. Il Farmaco Ed. Pr., 39, (1984). 46) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Pastoris O. Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia. J. Neurosci. Res., 11, (1984). 47) Arrigoni E, Benzi G, Curti D, Dagani F, Gallico S, Gorini A, Mandelli A, Marzatico F, Moretti A, Villa RF. Effect of hypoxia and pharmacological treatment on some enzyme activities in dog brain areas. Arch. Int. Pharmacodyn. Therap., 269, (1984). 48) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Taglietti M, Pastoris O. Recovery period after profound hypoglycemia. Influence of some metabolic modulators on the cerebral endogenous substrate utilization. Il Farmaco Ed. Pr., 39, (1984).

4 49) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Pastoris O. Role of drugs in recovery of metabolic function of rat brain following severe hypoglycemia. Neurochem. Res., 9, (1984). 50) Benzi G, Pastoris O, Villa RF, Giuffrida, AM. Influence of aging and exogenous substances on cerebral energy metabolism in posthypoglycemic recovery. Biochem. Pharmacol., 34, (1985). 51) Villa RF, Gorini A, Zanada F, Benzi G. Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus. Arch. Int. Pharmacodyn. Therap., 279, (1986). 52) Villa RF, Pastoris O. Influence du veillissement sur le métabolisme énérgetique cérébral pendant la récupération post-hypoglycemique chez le rat - application pharmacologique. J. Pharmacol., 17, (1986). 53) Benzi G, Pastoris O, Vercesi L, Gorini A, Viganotti C, Villa RF. Energetic state of aged brain during hypoxia. Gereontology, 33, (1987). 54) Villa RF, Pastoris O. Effect du veillissement et de divers agents pharmacologiques sur le métabolisme énérgetique cérébral au cours de la récupération posthypoglycemique chez le rat. La Press Méd., 16, (1987). 55) Benzi G, Pastoris O, Tentoni S, Villa RF. Modifications in cerebral lipid metabolism by severe glucose deprivation during aging. Neurobiol. Aging, 8, (1987). 56) Benzi G, Pastoris O, Villa RF. Changes induced by aging and drug treatment on cerebral enzymatic antioxidant system. Neurochem. Res., 13, (1988). 57) Benzi G, Pastoris O, Marzatico F, Villa RF. Influence of aging and drug treatment on the cerebral glutathione system. Neurobiol. Aging, 9, (1988). 58) Turpeenoja L, Villa RF, Magrì G, Giuffrida-Stella AM. Changes of mitochondrial membrane proteins in rat cerebellum during ageing. Neurochem. Res., 13, (1988). 59) Villa RF, Turpeenoja L, Benzi G, Giuffrida-Stella AM. Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum. Neurochem. Res., 13, (1988). 60) Gorini A, Arnaboldi R, Ghigini B, Villa RF. Brain cytochrome oxidase activity of synaptic and non-synaptic mitochondria during aging. Basic Appl. Histochem., 33, (1989). 61) Benzi G, Marzatico F, Pastoris O, Villa RF. Relationships between aging, drug treatment and the cerebral enzymatic antioxidant system. Exp. Gerontol., 24, (1989). 62) Villa RF, Arnaboldi R, Gorini A, Geroldi D. Action of piracetam and clonidine on different mitochondrial populations from hippocampus. Il Farmaco Ed. Sc., 44, (1989). 63) Vanella A, Villa RF, Gorini A, Campisi A, Giuffrida-Stella AM. Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging. J. Neurosc. Res., 22, (1989). 64) Benzi G, Pastoris O, Marzatico F, Villa RF. Age related effect induced by oxidative stress on the cerebral glutathione system. Neurochem. Res., 14, (1989). 65) Benzi G, Pastoris O, Marzatico F, Villa RF. Cerebral enzyme antioxidant system. Influence of aging and phosphatidylcholine. J. Cereb. Blood Flow Metabol., 9, (1989). 66) Villa RF, Gorini A, Lo Faro A, Dell Orbo C. A critique on the preparation and enzymatic characterization of synaptic and non-synaptic mitochondria from hippocampus. Cell. Mol. Neurobiol., 9, (1989). 67) Condorelli DF, Avola R, Ragusa N, Reale S, Renis M, Villa RF, Giuffrida-Stella AM. Age-dependent changes of nucleic acid labeling in different rat brain regions. Neurochem. Res., 14, (1989) 68) Villa RF, Gorini A, Geroldi D, Lo Faro A, Dell Orbo C. Enzyme activities in perikaryal and synaptic mitochondrial fractions from rat hippocampus during development. Mech. Aging Develop., 49, (1989).

5 69) Benzi G, Marzatico F, Pastoris O, Villa RF. Influence of oxidative stress on the agelinked alterations of the cerebral glutathione system. J. Neurosci. Res., 26, (1990). 70) Benzi G, Pastoris O, Dossena M, Marzatico F, Villa RF, Dagani F. Factors involved in the age-related alteration in the efficiency of the brain bioenergetics. Mech. Aging Develop., 56, (1990). 71) Villa RF, Ghigini B, Arnaboldi R, Geroldi D.Gorini A. Factors involved in drug interference on enzyme activities of three mitochondrial populations from rat hippocampus. Eur. J. Basic Appl. Histochem., 35, (1991) 72) Battino M, Bertoli E, Formiggini G, Sassi S, Gorini A, Villa RF, Lenaz G. Structural and functional aspects of the respiratory chain of synaptic and non-synaptic mitochondria derived from selected brain regions. J. Bioenerg. Biomembr., 23, (1991). 73) Benzi G, Pastoris O, Gorini A, Marzatico F, Villa RF, Curti D. Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents. Neurobiol. Aging, 12, (1991) 74) Villa RF, Turpeenoja L, Magrì G, Gorini A, Ragusa N, Giuffrida-Stella AM. Effect of hypoxia on mitochondrial protein composition of cerebral cortex during aging. Neurochem. Res., 16, (1991). 75) Villa RF, Turpeenoja L, Magrì G, Gorini A, Ragusa N, Giuffrida-Stella AM. Effect of hypoxia on protein composition of synaptic plasma membranes from cerebral cortex during aging. Neurochem. Res., 16, (1991) 76) Villa RF, Gorini A. Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging. Neurochem. Res., 16, (1991) 77) Benzi G, Curti D, Pastoris O, Marzatico F, Villa RF, Dagani F. Sequential damage in mitochondrial complexes by peroxidative stress. Neurochem. Res., 16, (1991) 78) Villa RF, Gorini A. Enzyme mitochondrial systems during aging: pharmacological implications. Life Sci.Adv., 10, (1991) 79) Battino M, Ferri E, Rodriguez Huertas JF, Pierluigi F, Genova ML, Marchetti M, Gorini A, Villa RF, Lenaz G. Natural distribution and occurrence of Coenzyme Q homologues. Membr. Biochem, 9, (1991) 80) Benzi G, Pastoris O, Marzatico F, Villa RF, Dagani F, Curti D. The mitochondrial electron transfer alteration as a factor involved in the brain aging. Neurobiol. Aging, 13, (1992). 81) Ragusa N, Villa RF, Magrì G, Ingrao F, Gorini A, Turpeenoja L, Giuffrida-Stella AM. Modifications of synaptosomal plasma membrane protein composition in various brain regions during aging. Int. J. Dev. Neuroscience, 10, (1992) 82) Villa RF, Arnaboldi R, Ghigini B, Gorini A. Mitochondrial factors involved in Parkinson s disease by MPTP toxicity in Macaca fascicularis and drug effect. Neurochem. Res., 17, (1992) 83) Villa RF, Ingrao F, Magrì G, Gorini A, Reale S, Costa A, Ragusa N, Avola R, Giuffrida- Stella AM. Effect of CDP-Choline treatment on mitochondrial and synaptosomal protein composition in different brain regions during aging. Int. J. Dev. Neuroscience, 11, (1993). 84) Benzi G, Gorini A, Ghigini B, Arnaboldi R, Villa RF. Synaptosomal non-mitochondrial ATPase activities and drug treatment. Neurochem. Res., 18, (1993). 85) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Effect of intermittent mild hypoxia and drug treatment on synaptosomal non-mitochondrial ATPase activities. J. Neurosci. Res., 34, (1993) 86) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Age-related alterations by chronic intermittent hypoxia on cerebral synaptosomal ATPase activities. J. Neural Transm., 44, (1994)

6 87) Villa RF, Arnaboldi R, Ghigini B, Gorini A. Parkinson-like disease by 1-Methyl-4- Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) toxicity in Macaca fascicularis: synaptosomal metabolism and action of dihydroergocriptine. Neurochem. Res., 19, (1994) 88) Benzi G, Gorini A, Ghigini B, Arnaboldi R, Villa RF. Modifications by hypoxia and drug treatment of cerebral ATPase plasticity. Neurochem. Res., 19, (1994) 89) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Synaptosomal non-mitochondrial ATPase activities: age-related alterations by chronic normobaric intermittent hypoxia. Neurochem. Int., 25, (1994). 90) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Age-related changes by hypoxia and TRH analogue on synaptic ATPase activities. Neurobiol. Aging, 15, (1994). 91) Pastoris O, Dossena M, Arnaboldi R, Gorini A, Villa RF. Age-related alterations of skeletal muscle metabolism by intermittent hypoxia and TRH-analogue treatment. Pharmac. Res., 30, (1994). 92) Castelluccio C, Baracca A, Fato R, Pallotti F, Maranesi M, Barzanti V, Gorini A, Villa RF, Parenti Castelli G, Marchetti M, Lenaz G. Mitochondrial activities of rat heart during ageing. Mech. Ageing Develop., 76, (1994). 93) Pastoris O, Dossena M, Foppa P, Arnaboldi R, Gorini A, Villa RF, Benzi G. Modifications by chronic intermittent hypoxia and drug treatment on skeletal muscle metabolism. Neurochem. Res, 20, (1995). 94) Battino M, Gorini A, Villa RF, Genova ML, Bovina C, Sassi L, Littarru GP, Lenaz G. Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat. Mech. Ageing Develop., 78, (1995). 95) Nicoletti VG, Tendi EA, Lalicata C, Reale S, Costa A, Villa RF, Guerrieri F, Ragusa N, Giuffrida-Stella AM. Changes of mitochondrial cytochrome c oxidase and F0F1 ATP synthase subunits in rat cerebral cortex during aging. Neurochem. Res., 20, (1995). 96) Benzi G, Gorini A, Ghigini B, Moretti A, Dagani F, Villa RF. Is the Mg++-ATPdependent proton pumping activity of the synaptic vesicles a factor involved in the cerebral hypoxia? Neurochem. Res., 21, 7-18 (1996) 97) Nicoletti VG, Tendi EA, Lalicata C, Reale S, Villa RF, Ragusa N, Giuffrida-Stella AM. Age-related changes of mitochondrial cytochrome c oxidase and F0F1 ATP synthase subunits contents in rat cerebral cortex. Arch. Gerontol. Geriatr., 22, (1996). 98) Gorini A, Ghigini B, Villa RF. Acetylcholinesterase activity of synaptic plasma membranes during ageing and effect of L-acetylcarnitine. Dementia, 7, (1996) 99) Battino M, Littarru GP, Gorini A, Villa RF. Coenzyme Q, peroxidation and cytochrome oxidase features after Parkinson s-like disease by MPTP toxicity in intra-synaptic and non-synaptic mitochondria from Macaca fascicularis cerebral cortex and hippocampus: action of diidroergocriptine. Neurochem. Res., 21, (1996) 100) Battino M, Svegliati Baroni S, Littarru GP, Bompadre S, Leone L, Gorini A, Villa RF. Coenzyme Q homologs and Vitamin E in synaptic and non-synaptic occipital cortex mitochondria in the ageing rats. Mol. Aspects Med., 18, (1997) 101) Villa RF, Gorini A. Pharmacology of lazaroids and brain energy metabolism: a review. Pharmacological Review, 49, (1997) 102) Genova ML, Bovina C, Marchetti M, Pallotti F, Tietz C, Biagini G, Pugnaloni A, Viticchi C, Gorini A, Villa RF, Lenaz G. Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non-synaptic mitochondria of aged rats. FEBS Lett., 410, (1997) 103) Nicoletti VG, Tendi EA, Console A, Privitera A, Villa RF, Ragusa N, Giuffrida-Stella AM. Regulation of cytochrome c oxidase and Fo-F1-ATPase subunits expression in rat brain during aging. Neurochem. Res., 23, (1998)

7 104) Gorini A, D Angelo A, Villa RF. Action of L-Acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex. Neurochem. Res., 23, (1998) 105) Gorini A, D Angelo A, Villa RF. Energy metabolism of synaptosomal subpopulations from different neuronal systems of rat hippocampus: effect of L-acetylcarnitine administration in vivo. Neurochem. Res., 24, (1999). 106) Villa RF, D Angelo A, Gorini A. ATPases of synaptic plasma membranes and vesicles from rat cerebral cortex during ageing and hypoxia. Ann. N. Y. Acad. Sci., 893, (1999). 107) Gorini A, Rancati A, D Angelo A, Devecchi E, Villa RF. Effect of in vivo administration of naloxone on ATP-ases's enzyme systems of synaptic plasma membranes from rat cerebral cortex. Neurochem. Res., 25, (2000). 108) Battino M, Quiles JL, Huergtas JR, Mataix JF, Gorini A, Villa RF. Cerebral cortex synaptic heavy mitochondria may represent the oldest synaptic mitochondrial population: biochemical heterogeneity and effects of L-acetylcarnitine. J. Bioenerg. Biomembr., 32, (2000) 109) Battino M, Bompadre S, Leone L, Villa RF, Gorini A. Coenzyme Q9 and Q10, Vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing. Biol Chem., 382, (2001) 110) Gorini A, Villa RF. Effect of in vivo treatment of clonidine on ATP-ases's enzyme systems of synaptic plasma membranes from rat cerebral cortex. Neurochem. Res., 26, (2001) 111) Gorini A, Canosi U, Devecchi E, Geroldi D.Villa RF. ATP-ases enzyme activities during ageing in different types of somatic and synaptic plasma membranes from rat frontal cerebral cortex. Progr. Neuro-Psychopharmacol. & Biol. Psychiatry., 26, (2002). 112) Villa RF, Gorini A, Hoyer S. ATP-ases of synaptic plasma membranes from hippocampus after ischemia and recovery during ageing. Neurochem. Res. 27, (2002). 113) Battino M, Ferreiro MS, Littarru GP, Quiles JL, Ramirez-Tortosa MC, Huertas JR, Mataix JF, Villa RF, Gorini A. Structural damages induced by peroxidation could account for functional impairment of heavy synaptic mitochondria. Free Rad. Res., 36, (2002). 114) Moretti A, Gorini A, Villa RF. Affective disorders, antidepressant drugs and brain metabolism. Mol. Psychiatr., 8, (2003). 115) Battino M, Bompadre S, Leone L, Devecchi E, Degiuli A, D Agostino F, Cambiè G, D Agostino M, Faggi L, Colturani G, Gorini A, Villa RF. Coenzyme Q, Vitamin E and Apo-E alleles in Alzheimer Disease. Biofactors, 18, (2003). 116) Villa RF, Gorini A, Hoyer S. Differentiated effect of ageing on the enzymes of Krebs cycle, electron transfer complexes, and glutamate metabolism of non-synaptic and intra-synaptic mitochondria from cerebral cortex.j.neuronal Transm, 113, (2006). 117) Villa RF, Gorini A, Hoyer S. Effect of ageing and ischemia on enzymatic activities linked to Krebs cycle, electron transfer chain, glutamate and aminoacids metabolism of free and intrasynaptic mitochondria of cerebral cortex. Neurochem. Res. 34, (2009). 118) Moretti A, Gorini A, Villa RF. Pharmacology and prevention of vascular dementia. CNS & Neurological Disorders Drug Targets. 10, (2011). 119) Villa RF, Ferrari F, Gorini A. Effect of in vivo L-acetylcarnitine administration on ATP-ases enzyme systems of synaptic plasma membranes from rat cerebral cortex. Neurochem. Res. 36, (2011). 120) Villa RF, Ferrari F, Gorini A. Functional proteomics of ATP-ases enzyme systems of rat striatum during aging. Neural. Reg. Res. 7, 6-12 (2012). 121) Villa RF, Ferrari F, Gorini A. Energy metabolism of rat cerebral cortex, hypothalamus and hypophysis during ageing. Neuroscience. 227, (2012).

8 122) Villa RF, Ferrari F, Gorini A. Effect of CDP-Choline on age-dependent modifications of energy- and glutamate-linked enzyme activities in synaptic and non-synaptic mitochondria from rat cerebral cortex. Neurochem. Int., 61, (2012). 123) Villa RF, Ferrari F, Gorini A. ATP-ases of synaptic plasma membranes in striatum: enzymatic systems for synapses functionality by in vivo administration of L- acetylcarnitine in relation to Parkinson s disease. Neuroscience, 248, (2013). 124) Villa RF, Ferrari F, Gorini A, Hoyer, S. Energy metabolism of cerebral during ageing, ischemia and post-ischemic recovery assessed by functional proteomics of enzymes. Neurochem. Int., 63: (2013) 125) Villa RF, Ferrari F, Gorini A. Functional proteomics related to energy metabolism of synaptosomes from different neuronal systems of rat hippocampus during aging. J. Proteome Res., 12: (2013) 126) Moretti A., Ferrari, F.,Villa RF. Neuroprotection for ischaemic stroke: current status and challenges. Pharmacology and Therapeutics, 146, (2015); on-line ) Ferrari F, Gorini A., Villa RF. Energy metabolism of synaptosomes from different neuronal systems of rat cerebellum during aging: a functional proteomic characterization. Neurochem. Res., 40, (2015); on-line ) Villa RF, Ferrari F, Gorini A. Functional proteomics of synaptic plasma membrane ATP-ases of rat hippocampus: effect of L-Acetylcarnitine in vivo administration and relationships with Dementia and Depression pathophysiology. Eur. J. Neuropharm., 756, (2015). 129) Moretti, A., Ferrari F, Villa RF. Pharmacological therapy of acute ischaemic stroke: achievements and problems. Pharmacology and Therapeutics, 153, (2015). 130) Villa, R.F., Ferrari, F. Functional Proteomics as Marker for neurological and psychiatric disorders: the first application to dementia for an immediate future. J. Neurol. Neurosci. 7, 1-4 (2016). 131) Villa RF, Ferrari F, Gorini A, Brunello, N, Tascedda, F. Effect of Desipramine and Fluoxetine on energy metanolism of cerebral mitochondria. Neuroscience, 330, (2016). 132) Ferrari, F., Villa, R.F. (2016). The neurobiology of depression: an integrated overview from the biological theories to clinical evidence. Mol. Neurobiol., 000, (2016). Doi: /s y 133) Villa R.F., Ferrari F., Moretti, A. (2016). Effects of neuroprotectants before and after stroke: statins and anti-hypertensives. In: Lapchak, P., Zhang, J. (Eds.), Neuroprotective Therapy for Stroke and Ischemic Disease. Springer. In press. PARTE II. PUBBLICAZIONI SPERIMENTALI EDITE SU ATTI DI CONGRESSI E SU RIVISTE SPECIALIZZATE A CARATTERE DIVULGATIVO O SU LIBRI 1) Benzi G, Arrigoni E, Pastoris O, Villa RF. Effect of pharmacological treatment by vasodilators on muscle metabolism. Atti I Congresso della Società di Microangiologia e Microcircolazione, Cagliari, ) Arrigoni E, Fanfani A, Montani A, Scelsi R, Villa RF. Effetti del veleno di Phoneyusa lesserti (Araneae): rilievi biochimici, istologici ed enzimo istochimici a livello della muscolatura striata di ratto. Pubbl. Ist. Entom. Argr. Univ. Pavia & C.N.R., 4, 3-11 (1976). 3) Villa RF, Arrigoni E, Pastoris O, Benzi G. Studio sulla eventuale interferenza della caffeina e della papaverina su alcune vie cvicarie della metabolizzazione del piruvato attivate dall allenamento di durata. Medicina dello Sport, 29, (1976) 4) Villa RF, Arrigoni E, Arcelli, E., Benzi G. Allenamento ed attività enzimatiche mitocondriali del muscolo scheletrico di ratto. Medicina dello Sport, 29, (1976)

9 5) Benzi G, Arrigoni E, Villa RF, Agnoli A. Effect of acute hyperammonemia on metabolism and cerebral energy state. In "Transmethylation and the Central Nervous System" (V.M. Andreoli, A. Agnoli and C. Fazio, eds.), pp , Springer- Verlag, Berlin (1978). 6) Benzi G, Arrigoni E, Villa RF, Agnoli A. Influence of phenobarbital on cerebral metabolic pathways related to energy transduction. In "Cerebral Vascular Disease" (J.S. Meyer, H. Lechner and R. Reivich, eds.), pp , Excerpta Medica, Amsterdam-Oxford (1978). 7) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa RF. Role of cerebral enzymatic activities in the relationships between energy metabolism and amino acid acting as neurotrasmitters. In "Cerebral Circulation" (A. Bes and G. Géraud, eds.), pp , Excerpta Medica, Amsterdam-Oxford (1979) 8) Benzi G, Villa RF, Arrigoni E, Actividades enzimaticas cerebrales en relaciòn con la transferencia de energia en el cerebro de rata adulta: efecto del tratamiento con algunos fàrmacos. In "Transtornos Cerebrovasculares", pp , Excerpta Medica, Amsterdam-Oxford (1979). 9) Agnoli A, Palesse N, Bocola V, Ruggieri S, Leonardis, G, Varassi G, Ciamitti B, Benzi G, Villa RF. Protezione del SNC dall'ipossia ipossica ed ischemica. Studio comparativo sull'azione dei barbiturici e dell'alfaxolone-alfadolone. Acta Anaesth. Ital., 30, (1979). 10) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF. Drug interference on the age-dependent modification of the cerebral enzymatic activities related to energy transduction. In "Aging of the Brain and Dementia" (L. Amaducci, A.N. Davison and P. Antuono, eds.), Vol. 13, pp , Raven Press, New York (1980). 11) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF. Aging.and brain enzymes. In "The Aging Brain. Neurological and Mental Disturbances" (G. Barbagallo-Sangiorgi and A.N. Exton-Smith, eds.), pp. 1-13, Plenum Press, New York (1981). 12) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF. Les modifications enzymatiques du cerveau age chez le rat. In "Souffrance Cérébrale et Précurseurs des Phospholipides", Paris (1981). 13) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF, Agnoli A. Differential pharmacological action as a function of age on cerebral enzymatic activities related to energy transduction. In "Les Alpha-Bloquants: Pharmacologie Expérimentale et Clinique", pp , Masson, Paris (1981). 14) Villa RF, Curti D, Dagani F, Polgatti M, Marzatico F, Benzi G, Rat brain cortex subfractions: action of an alpha-bloking agent on some enzymatic activities. In "Pharmacologie Expérimentale et Clinique", pp , Masson, Paris (1981). 15) Villa RF, Curti D, Marzatico F, Polgatti M, Dagani F. Changements de certaines activities enzymatiques dans l'ischemie cérébrale totale chez le rat. In "Souffrance Cérébrale et.précurseurs des Phospholipides", pp , Paris (1981). 16) Marzatico F, Arrigoni E, Curti D, Villa RF, Benzi G, Modifications produced by ischemia on some cerebral enzyme.activities related to energy transduction. It. J. Biochem., 31, (1982). 17) Villa RF, Gorini A. Experimentacao farmacologica com CDP-colina. Acta International Congress, Lisboa (1982). 18) Benzi G, Arrigoni E, Pastoris O, Dossena M, Gorini A.Villa RF. Effects of ergot derivatives on the metabolic changes induced by acute hypoxia on the synaptosomes from dog brain. In "Aging Brain and Ergot Alkaloids" (A. Agnoli, G. Crepaldi, P.F., Spano and M. Trabucchi, eds.), Vol. 23, pp , Raven Press, New York (1983). 19) Villa RF, Benzi G, Synaptosomes from dog cerebral cortex: action of CDP-choline and pentobarbital during hypoxia on energy metabolism. In "Cerebral Pathology in Old Age", pp , Emiras, Pavia (1983).

10 20) Benzi G, Villa RF, Gorini A. Interferenza della diidroergocristina sul metabolismo energetico cerebrale. Giornale di Neuropsicofarmacologia, 5, (1983). 21) Benzi G, Pastoris O, Villa RF. Pharmacobiological interventions of CDP-choline in hypoxia and aging of the brain. In "Novel Biochemical, Pharmacological and Clinical Aspects of Cytidine Diphosphocoline" (V. Zappia, B. Nilsson, E.P. Kennedy and P. Galletti, eds.), pp , Elsevier, New York (1985). 22) Villa RF, Gorini A, Zanada F, Benzi G. Changes of acetylcholinesterase and (Na+K+)ATPase activities of synaptic plasma membranes from cerebral cortex of 4 and 8 month-old rats. It. J. Biochem., 35, A120 (1986). 23) Villa RF, Gorini A, Zanada, F, Benzi G. Enzyme activities in perikaryal and synaptic mitochondrial fractions from rat hippocampus. In "Neuroendocrine System and Aging" (P. Vezzadini, A. Facchini and G. Labò, eds.) Vol. 8, pp , Eurage (Rijswijk) (1986). 24) Benzi G, Pastoris O, Villa RF. Metabolic changes by severe hypoglycemia during brain aging. In "Modulation of Central and Pheripheral Transmitter Function" (G. Biggio, P.F. Spano, G. Toffano and G.L. Gessa, eds.), Vol. 3, pp , Springer-Verlag, Padova (1986). 25) Benzi G, Villa RF, Pastoris O, Tentoni, S, Dossena M, Giuffrida, AM. Influence of aging on the derangement of brain bioenergetic by hypoxic insult. In "Pharmacology of Cerebral Ischemia" (J. Krieglstein, ed.), pp , Elsevier (1986). 26) Benzi G, Pastoris O, Tentoni, S, Dossena M, Marzatico F, Villa RF. Modificazioni indotte dall'invecchiamento sul metabolismo dei lipidi cerebrali durante grave carenza di glucosio. In "Lipidi ed Invecchiamento", pp. 5-18, Abano Terme (1986). 27) Benzi G, Marzatico F, Pastoris O, Villa RF, Giuffrida, AM. Modifications des métabolismes énérgetique, lipidique et protéique et leurs roles au cours du veillissement cérébral. In "Investigations Cliniques et Paracliniques dans le Vieillissement Cérébral", pp , Paris (1987). 28) Giuffrida-Stella, AM, Alberghina M, Avola, R, Condorelli, DF, Ragusa N, Turpeenoja L, Vanella A, Villa RF, Benzi G, Effetto della somministrazione cronica di CDPcolina sul metabolismo degli acidi nucleici delle proteine in diverse aree cerebrali durante l'invecchiamento.gior. Geront., XXXVI, (1988). 29) Avola, R, Villa RF, Condorelli, DF, Turpeenoja L, L., Magrì G, Ragusa N, Giuffrida- Stella, AM. Changes of brain metabolism during aging induced by drug treatment. Advances in Miochemistry, 2, (1989). 30) Gorini A, Arnaboldi R, Villa RF. Age-related changes in acetylcholinesterase activity od synaptic plasma membranes from rat cerebral cortex frontal area. It. J. Biochem., 38, 112A-115A (1989). 31) Battino M, Bertoli E, Formiggini G, Gorini A, Villa RF, Lenaz G. Comparative investigations on animal mitochondria ubiquinone content. A qualitative and quantitative study. In "Highlights in Ubiquinone Research" (G. Lenaz, O. Barnabei, A. Rabbi and M. Battino, eds.), pp , Taylor and Francis Ltd., London, (1989). 32) Avola, R, Condorelli, DF, Ragusa N, Turpeenoja L, L., Magrì G, Villa RF, Giuffrida- Stella, AM. Age dependent changes of gene expression in different brain regions. In "Role et évolution de l'animal de laboratoire dans la recherche biomédicale", pp , Collection Fondation M. Merieux, Lyon, France, (1989). 33) Benzi G, Pastoris O, Marzatico F, Villa RF. Effect induced by oxidative stress on the cerebral glutathione system during aging. In "Role et évolution de l'animal de laboratoire dans la recherche biomédicale", pp ,, Collection Fondation M. Merieux, Lyon, France, (1989). 34) Turpeenoja, L., Villa, R.F., Lahdesmaki, P., Giuffrida-Stella, A.M.. Age-related modifications of synaptosomal plasma membranes proteins in various brain regions. Acta Neurol. Scand., 79, (1989)

11 35) Benzi G, Marzatico F, Pastoris O, Villa RF. Age-related modifications of the cerebral enzyme antioxidant system in different brain regions. In "50th Anniversary of Phospholipid Research" (K.J. Gundermann and R. Schumacher, eds.),pp , wbn-verlag - Bingen/Rhein (1990). 36) Villa RF., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Age-related changes of enzyme activity of motochondrial populations from hippocampus and striatum. Minerva Biotech., 2, 381 (1990). 37) Villa RF, Arnaboldi R, Ghigini, B., Geroldi D, Gorini A. Effect of CDP-choline on agerelated changes of non-synaptic mitochondrial enzyme systems of cerebral cortex. Pharmacol. Res., 22, 496 (1990). 38) Villa RF, Gorini A. Effect of drug treatment on age-related changes of brain enzyme activity in different mitochondrial populations Arch. Geront. Geriatr., 12(2), (1991). 39) Benzi G, Marzatico F, Pastoris O, Villa RF. Influenza degli stress ossidativi sulle alterazioni età-dipendenti del sistema glutationico cerebrale. In I radicali liberi in Fisiologia e Patologia. Atti XXII Congresso Nazionale della Società Italiana per lo studio del metabolismo normale e patologico, pp. 1-19, Mattioli (1991). 40) Gazzaruso C, Villa RF, Priori F, Falcone C, Geroldi D, Fratino P. Lipoproteina (a), inibitore-1 dell attivatore del plasminogeno e trigliceridi nella cardiopatia ischemica. Giorn. It. Chim. Clin., 17, (1992). 41) Villa RF, Gorini A.Benzi G, Tecnologie preparativa ed analitica delle popolazioni nonsinaptiche ed intra-sinaptiche (due tipologie) dei mitocondri di corteccia cerebrale di ratto. In Metodi di Neurobiologia : metodi per lo studio del metabolismo cerebrale, pp. 1-7, Il Pensiero Scientifico Editore (1993). 42) Villa RF, Arnaboldi R, Ghigini B, Gorini A. Synaptic non-mitochondrial ATPase activities as a pharmacological model for the evaluation of drugs s action on cerebral energy metabolism during ageing British Journal of Pharmacology. Proceeding Supplement, 210P, (1993) 43) Ingrao, F., Turpeenoja, L., Villa RF, Magrì, G., Gorini, A., Reale, S., Costa, A., Ragusa, N., Avola, A., Giuffrida-Stella, A.M. Age dependent changes of mitochondrial and synaptosomal membrane protein composition in different brain regions. It. J. Biochem., 42, 148A-149A (1993). 44) Garzaniti A, Bonetti G, Buscaglia P, Villa RF, Giudici A, Gazzaruso C, Pozzi M, Geroldi D, Finardi G. Evidences for a non genetic nature of high Lp(a) levels in hemodialysis patients. It. J. Biochem., 43, 302A-303A (1994). 45) Nicoletti, V.G., Tendi, E.A., Lalicata, G., Reale, S., Costa, A., Villa RF, Guerrieri, F., Ragusa, N., Giuffrida-Stella, A.M. Modifications of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits content in rat cerebral cortex during aging. It. J. Biochem., 44, (1995). 46) Benzi G, Villa RF, Dagani F. Modificazioni bioenergetiche da ipossia cerebrale. Ruolo della ATPasi nel turnover del glutamato. In Il cervello senile ; pp , Pythagora Press (Milano) (1995). 47) Villa RF, Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. I sistemi enzimatici ATPasici sinaptosomiali: un modello per la valutazione del metabolismo energetico cerebrale. In Saggi di Neuropsicologia Infantile, Psicopedagogica e Riabilitazione, Vol. I, pp. 1-7, Masson (1995). 48) Genova ML, Gorini A. Villa RF, Tietz, C., Pallotti F, Pugnaloni, A., Biagini G, Viticchi C, Brighetti, B., Bovina C, Lenaz G. Changes in different mitochondrial populations from cerebral cortex of aged rats. It. J. Biochem., 45, (1996). 49) Villa RF, Ghigini B, Maggi AM, D Angelo A, Gorini A. Synaptic plasma membranes from striatum during ageing: changes of ATPases enzymatic activities. Fundamental & Clinical Pharmacology, 223 (1996) 50) Villa RF, Maggi AM, D Angelo A, Canosi U, Geroldi D, Gorini A. ATPases of synaptosomes, synaptic plasma membranes and synaptic vesicles during ageing and chronic hypoxia. J. Neural Transm, 103, LIII (1996)

12 51) Genova ML, Bovina C, Pallotti F, Carraro S, Sgarbi G, Castaldini C, Biagini G, Viticchi C, Gorini A.Villa RF, Lenaz G. Age-related changes in nonsynaptic and synaptic mitochondria from rat cerebral cortex. It. J. Biochem., 46, (1997) 52) Battino M, Svegliati Baroni S, Littarru GP., Bompadre S, Leone L, Gorini A, Villa RF. Coenzyme Q homologs and vitamin E in synaptic and non-synaptic occipital cerebral cortex mitochondria in the aging rat. In "Molec. Aspects Med." (G.P. Littarru, R. Alleva, M. Battino, K. Folkers, eds.), Vol. 18, pp , Pergamon Press (1997). 53) Canosi U, Gorini A, Villa RF, Geroldi D. Analysis of apolipoproteins(a) isoforms and lipoprotein(a) levels in a family.atti della Associazione Genetica Italiana, XLIII, (1997). 54) Villa RF, D Angelo A, Canosi U, Geroldi D, Gorini A. Le variazioni indotte dall'invecchiamento cerebrale sulle attività catalitiche delle ATP-asi delle membrane plasmatiche sinaptiche della corteccia cerebrale frontale di ratto. Giornale di Gerontologia, XLVI, 239 (1998) 55) Villa RF, D Angelo A, Canosi U, Geroldi D, Gorini A. Le variazioni indotte dall'invecchiamento cerebrale sulle attività catalitiche delle ATP-asi in differenti popolazioni sinaptosomiali di ippocampo. Giornale di Gerontologia, XLVI, 240 (1998) 56) Villa RF, D Angelo A, Gorini A. Catalytic properties of ATP-ases of selected synaptosomes from hippocampus during aging. Neurosci. Lett., S52, (1999) 57) Villa RF, D Angelo A, Gorini A. Attività catalitiche delle ATP-asi di differenti tipi di membrane plasmatiche sinaptiche e somatiche della xcorteccia cerebrale frontale durante l'invecchiamento. Giornale di Gerontologia, XLVII, (1999) 58) Villa RF, D Angelo A, Devecchi E, Rancati A, Geroldi D, Gorini A. Modificazioni indotte dall'invecchiamento sulle attività delle ATP-asi delle membrane plasmatiche sinaptiche e somatiche della corteccia cerebrale. Giornale di Gerontologia, XLVII, 319(2000) 59) Battino M, Ferreiro S, Littarru GP, Quiles JL, Huertas JR, Mataix JF, Villa RF, Gorini A. Biochemical heterogeneity of brain mitochondria. Atti della "Second Conference of the International Coenzyme Q Association" Frankfurt (2000). 60) Villa RF, Gorini A. Neuronal signaling during hypoxia and pharmacological treatment. Atti del First Colloquia of the National Academy of Sciences Neuronal Signaling National Academy of Sciences, Washington USA (2001). 61) Gorini A, Devecchi E, Villa RF. Effect of clonidine on ATP-ases Activities of synaptic plasma membranes from cerebral cortex. Pharm. Res., 43, Suppl. A (2001). 62) Villa RF, Devecchi E, Gorini A. Effect of naloxone treatment on ATPases activities of synaptic plasma membranes from rat hippocampus. Eur. Neuropsychopharm., 11, (2001) 63) Villa RF, Devecchi E, Brera F, Degiuli A, D Agostino A, D Agostino M, Cambiè G, Gorini A. Mitochondrial energy-linked enzymes in lymphocytes during ageing as biochemical markers for drug s action. J. Clinical Pharmac., 44, 1197 (2004) 64) Villa RF, Devecchi E, Brera F, Degiuli A, D Agostino A, D Agostino M, Cambiè G, Faggi L, Colturani G, Gorini A. Energy-linked enzymes in lymphocytes of patients with a diagnosis of dementia. J. Clinical Pharmac., 45, 1071 (2005) 65) Villa RF, Gorini A, Brera F, Geroldi D. Functional proteomics of lymphocytes is related to energy failure in acute stroke. Acta Pharmac. Sinica, 27, (2006) 66) Villa, R.F., A. Gorini, D. Geroldi, G. Pero, F. Brera Energy metabolism of lymphocytes from acute stroke patients J. Cereb. Blood Flow and Metabol., 27, BP56-09M (2007) 67) Villa RF, Gorini A. Parkinson-like disease by 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine (MPTP) toxicity on energy-linked non-synaptic and intrasynaptic mitochondrial enzyme systems from Macaca fascicularis brain. In

13 «Mitochondria: Structure, Functions and Dysfunctions», Oliver L. Svensson Ed., Nova Publisher, Hauppauge New York, U.S.A., (2010) 68) Villa, R.F. Handling Editor for Sensory stimulation based complete protection from ischemic stroke remains stable at 4 months post-occlusion of MCA by Hancock, A.M., Lay, C.C., Davis, M.F. and Frostig, R.D. In Drugs for Stroke, Roberto F. Villa, Ed., Special Issue Journal of Neurological Disorders, OMICS Publishing Group, U.S.A. (2013) 69) Ferrari, F., Geroldi D., Gorini A., Pero, G., Hoyer, S., Villa, R.F. Mitochondrial energy metabolism of brain and lymphocytes after ischemia and recovery during aging. Cerebrov. Dis, 39, S140, (2015) 70) Ferrari, F., Devecchi, E., Pero, G., Gorini, A, Villa, R.F. Bioenergetic characterization of lymphocytes from stroke patients. Cerebrov. Dis, 41, S44, (2016) 71) Villa, R.F., Ferrari, F., Moretti, A. Effects of neuroprotectants before and after stroke: statints and anti-hypertensives. In Journal of Neurology & Neurophysiology, Paul A. Lapchak, Editor J. Neurol. Neurophys. and Associate Editor of Translational Stroke Research, Edition 2016, U.S.A. in corso di stampa. Parte III. RELAZIONI, COMUNICAZIONI e POSTERS PRESENTATI A CONGRESSI NAZIONALI ED INTERNAZIONALI 1) Congresso Internazionale: "La Terapia Medica della Ischemia Cerebrale". Azione della (-)eburnamonina, papaverina ed UDP-glucoso sul metabolismo energetico cerebrale in condizioni di ipossia ed ischemia sperimentale. Milano, (1977). 2) II Rencontre Franco-Italienne de Geriatrie et de Gerontologie-Psychiatrie. Effets d'un traitement expérimental au long cours sur quelques activitatés enzymatiques cérébrales. Martigues, Francia (1978). 3) Satellite Sympsosium of 7th International Congress of Pharmacology. Phenobarbital interference on cerebral metabolism related to energy transduction. Rheims, Francia (1978). 4) 9th International Salzburg Conference on Cerebral Vascular Disease. Influence of phenobarbital on cerebral metabolic pathways related to energy transduction. Salzburg, Austria (1978). (1)*5) IInd European Neuroscience Meeting. Villa, R.F., Benzi, G. Pharmacological action on energy-related enzyme activities of rat brain subfractions. Firenze (1978). 6) Congresso Internazionale: "Omeostasi e Senescenza". Influenza del trattamento cronico con vari farmaci su alcune attività enzimatiche cerebrali correlate con la liberazione di energia. Parma (1978). 7) Congresso Nazionale: "L'Ischemia Cerebrale". Azioni farmacologiche sul metabolismo energetico in condizioni di ipossia ed ischemia cerebrale sperimentale. Roma (1978). (2)*8) IIIrd European Neuroscience Meeting. Villa, R.F., Curti, D., Dagani, F., F. Marzatico A study on enzymatic activities of glycolisis, TCA cycle, electron transfer chain and cholinergic transmission in purified mitochondria and crude synaptosomes from different rat brain areas. Roma (1979).

14 (3)*9) IIIrd European Neuroscience Meeting. Villa, R.F., Dagani, F., Curti, D., F. Marzatico Behaviour of some enzymatic activities related to energy transduction during experimetal ischemia in rat brain. Roma (1979). 10) Symposium International les "Alpha-boquants". Villa, R.F., Dagani, F., Curti, D., F. Marzatico Rat brain cortex subfractions: action on an alpha bloking agent on some enzymatic activities. Paris, Francia (1979). 11) Symposium International les "Alpha-boquants". Villa, R.F., Dagani, F., Curti, D., F. Marzatico Differentiated pharmacological action as a function of age on cerebral enzymatic activities related to energy transduction. Paris, Francia (1979). (4)*12) XX Congresso della Società Italiana di Farmacologia. Curti, D., Dagani, F., Villa, R.F., G. Benzi Stimolazione beta adrenergica ed enzimi mitocondriali e sinaptosomiali di corteccia cerebrale di ratto. Verona (1980). (5)*13) XX Congresso della Società Italiana di Farmacologia. Dagani, F., Villa, R.F., G. Benzi Barbiturici e metabolismo cerebrale: effetto su intermedi ed enzimi. Verona (1980). (6)*14) XX Congresso della Società Italiana di Farmacologia. Marzatico, F., Villa, R.F., G. Benzi Curve dose/azione e tempo/azione di alcune molecole biologiche valutate in vivo mediante lo studio delle attività enzimatiche sul cervello di ratto. Verona (1980). 15) Congresso Internazionale: "Deoxyglucose Uptake and Oxigen Consumption: a Metabolic Approach to Cerebral Function". Villa, R.F., G. Benzi Effect of eburnamonine on brain energy metabolism. Paris, Francia (1980). 16) Convegno Nazionale: "Cerebropatie Senili". Risposte biochimiche cerebrali differenziate in funzione dell'età. Parma (1980). 17) Congresso Internazionale: "Souffrance Cérébrale et Précurseurs des Phospholipides". Villa, R.F., G. Benzi Les modofications enzymatiques du cerveau chez le rat. Paris, Francia (1980). 18) Congresso Internazionale: "Souffrance Cérébrale et Précurseurs des Phospholipides". Villa, R.F., G. Benzi Changements de certaines activities enzymatiques dans l'ischemie cerebrale totale chez le rat. Paris, Francia (1980). 19) Congresso Internazionale: "Le Cerebropatie Croniche, Vascolari e Cellulari". Aspetti biochimici della azione dei farmaci. Stresa (1981). (7)*20) International Symposium on "Nervous System Regeneration". Rapisarda, A., Villa, R.F., Fulle, D., Benzi, G., Giuffrida, A.M. Enzymatic activities related to energy transduction during hypoglossal nerve regeneration. Catania (1981). 21) 12 World Congress of Neurology.

15 Villa, R.F., G. Benzi Drug action on cerebral metabolic changes induced by acute hypoxia in dog brain synaptosomes. Kyoto, Giappone (1981). 22) 27 Congresso Nazionale Società Italiana di Biochimica: "Gruppo di Neurochimica Dagani, F., Gorini, A., Polgatti, M., Villa, R.F., Benzi, G. Metaboliti ed attività enzimatiche cerebrali correlate con la trasduzione energetica valutate nei sinaptosomi e nei mitocondri; trattamento farmacologico. Parma (1981). (8)*23) 27 Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Dagani, F., Gorini, A., Polgatti, M., Villa, R.F., Benzi, G. Attività enzimatiche correlate con la trasduzione di energia valutate nei mitocondri liberi ed intrasinaptosomiali di corteccia cerebrale di ratto. Parma (1981). (9)*24) 27 Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Marzatico, F., Curti, D., Villa, R.F., Benzi, G. Effetto della ischemia totale sulle attività enzimatiche connesse con la trasduzione energetica in varie frazioni subcellulari di cervello di ratto. Parma (1981). (10)*25) 27 Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Curti, D., Polgatti, M., Dagani, F., Marzatico, F., Gorini, A., Villa, R.F., Benzi, G. Caratterizzazione enzimatica di varie frazioni subcellulari in diverse zone cerebrali di ratto. Parma (1981). (11)*26) 27 Congresso Nazionale della Società Italiana di Biochimica. Ibidem Rapisarda, A, Villa, R.F., Gorini, A., Giuffrida, A.M. Attività enzimatiche correlate con la trasduzione energetica durante i processi rigenerativi del nervo ipoglosso di coniglio. Parma (1981). (12)*27) 27 Congresso Nazionale della Società Italiana di Biochimica. Ibidem Villa, R.F., Pastoris, O., Arrigoni, E., Benzi, G. Modificazioni età-dipendenti dello stato metabolico sinaptosomiale dell'area corticale motoria di cane. Parma (1981). (13)*28) XXI Congresso Società Italiana di Farmacologia e Joint Meeting con la British Pharmacological Society. Villa, R.F., Gorini, A., Arrigoni, E., Benzi, G. Metabolic changes induced by hypoxia on synaptosomes from dog brain. Effect of dihydroergocristine. Napoli (1981). 29) International Seminary at "Max Plank Institut fur Biophysikalische Chemie, Abteilung Neurochemie". Villa, R.F.. Cerebral energy metabolism. Gottingen, Germania Ovest (1982). 30) Convegno di Aggiornamento della Società Italiana di Farmacologia. Interferenza della diidroergocristina sul metabolismo energetico cerebrale. Torino (1982). 31) Symposium International Startonyl. CDP-choline: experimental pharmacology. Lisboa, Portogallo (1982). 32) Meeting of Neuropharmacology. Modificazioni delle attività enzimatiche cerebrali indotte dalla somministrazione ripetuta di farmaci potenzialmente attivi sul metabolismo energetico cerebrale. Urbino (1982).