N. lesioni trattate e rapporto B/M

N. lesioni trattate e rapporto B/M Benigno, N=256 Maligno, N=1436 Altro, N=8 Ignoto, N=140 N=405 N=161 N=179 N=223 N=87 N=171 N=353 N=99 N=162 1 2 3 4 5 6 7 8 9 B/M 0.18 B/M 0.16 B/M 0.12 B/M 0.17 B/M 0.05 B/M 0.15 B/M 0.24 B/M 0.19 B/M 0.28 2015

1. Cancri con diagnosi preoperatoria (B5/C5) 9 59.4 59.3 69.2 67.1 72.3 71.9 77 77.3 78.9 82.1 83.4 85.7 84.8 87.6 87.6 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=524 N=546 N=601 N=779 N=858 N=860 N=900 N=999 N=1187 N=1078 N=1251 N=1243 N=1335 N=1347 N=1337 N=14845 Trend temporale 2001 2015

1. Cancri con diagnosi preoperatoria (B5/C5) 94.4% 92.3% 91.5% 91.3% 90.4% 87.7% 85.7% 80% 76.1% N=107 N=117 N=177 N=264 N=75 N=81 N=232 N=150 N=134 Dip. 9 Dip. 2 Dip. 4 Dip. 1 Dip. 5 Dip. 8 Dip. 7 Dip. 3 Dip. 6 Miss. 0.4% Miss. 2.7% Miss. 0.9% Risultato 87.6%, 9 dipartimenti, N=1337, 0.4% missing 87.6%

2a. Invasivi con tipo istologico, grading, ER/PgR, stage e dimensioni registrati 9 1.8 1.4 1.4 17.8 13.6 12.8 10.2 6.1 41.2 64.6 67.9 67.5 71.5 76.5 75.2 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=438 N=417 N=503 N=656 N=742 N=735 N=849 N=842 N=1011 N=922 N=1067 N=1075 N=1133 N=1143 N=1161 N=12694 Trend temporale 2001 2015

2a. Invasivi con tipo istologico, grading, ER/PgR, stage e dimensioni registrati N=117 N=95 N=159 N=222 N=99 N=133 N=66 N=74 N=196 Dip. 6 Dip. 9 Dip. 4 Dip. 1 Dip. 2 Dip. 3 Dip. 5 Dip. 8 Dip. 7 75.2% 96.6% 93.7% 91.2% 80.2% 79.8% 73.7% 69.7% 48.6% 45.4% Risultato 75.2%, 9 dipartimenti, N=1161, 0% missing

2b. Non invasivi con grado e tipo istologico registrati 9 54.3 51.5 59.3 64.2 62.9 61.6 69.9 70.7 85.5 95.1 94 93.1 91.7 98.1 93.2 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=86 N=129 N=99 N=123 N=116 N=125 N=136 N=157 N=179 N=156 N=184 N=168 N=202 N=204 N=176 N=2240 Trend temporale 2001 2015

2b. Non invasivi con grado e tipo istologico registrati N=36 N=18 N=17 N=17 N=12 N=7 N=42 N=9 N=18 Dip. 7 Dip. 4 Dip. 3 Dip. 6 Dip. 9 Dip. 8 Dip. 1 Dip. 5 Dip. 2 93.2% 100% 100% 100% 100% 100% 100% 88.1% 77.8% 72.2% Risultato 93.2%, 9 dipartimenti, N=176, 0% missing

4. Rx pezzo in 2 proiez. perpend. nei casi con sole microcalcificazioni 8 81.2 88.7 84.2 83.5 93.6 87.5 84.6 93.9 93.5 86.2 84.4 85.2 87.8 84.6 89.9 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=53 N=75 N=80 N=109 N=130 N=95 N=128 N=103 N=183 N=147 N=190 N=198 N=202 N=228 N=217 N=2138 Trend temporale 2001 2015

4. Rx pezzo in 2 proiez. perpend. nei casi con sole microcalcificazioni 100% 95.8% 90.9% 90.6% 83.9% 79.2% 65.4% N=1 N=26 N=11 N=57 N=64 N=24 N=34 Dip. 9 Dip. 4 Dip. 8 Dip. 1 Dip. 7 Dip. 3 Dip. 6 Miss. 7.7% Miss. 7% Miss. 3.1% Miss. 23.5% Risultato 84.6%, 7 dipartimenti, N=217, 7.4% missing 84.6%

5a. Trattamento entro 30 giorni dalla indicazione terapeutica 9 35.6 49.6 48 52.1 52.9 45.7 45.3 44.6 34.4 34.1 33.3 33.2 34 35.8 33.4 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=572 N=611 N=593 N=841 N=871 N=868 N=871 N=903 N=1126 N=1209 N=1395 N=1227 N=1318 N=1467 N=1455 N=15327 Trend temporale 2001 2015

5a. Trattamento entro 30 giorni dalla indicazione terapeutica 75.4% 46.4% 46.3% 46% 33.2% 25.3% 25.1% 23.2% 11.7% N=74 N=151 N=114 N=147 N=291 N=196 N=263 N=125 N=94 Dip. 5 Dip. 6 Dip. 2 Dip. 3 Dip. 1 Dip. 4 Dip. 7 Dip. 9 Dip. 8 Miss. 23% Miss. 8.6% Miss. 28.1% Miss. 5.4% Miss. 16.2% Miss. 7.1% Miss. 1.5% Risultato 33.4%, 9 dipartimenti, N=1455, 9.3% missing 33.4%

5b. Trattamento entro 42 giorni dal primo esame di approfondimento diagnostico 9 33.3 33.6 34.3 31 26.9 28.9 37.1 37.1 28.4 31.1 29.6 30.5 28.8 21.8 21.8 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=572 N=611 N=593 N=841 N=871 N=868 N=871 N=903 N=1126 N=1209 N=1395 N=1324 N=1440 N=1467 N=1455 N=15546 Trend temporale 2001 2015

5b. Trattamento entro 42 giorni dal primo esame di approfondimento diagnostico 46% 45.8% 32% 28.7% 28.3% 25.4% 11.3% 11.1% 2.8% N=151 N=74 N=125 N=94 N=114 N=263 N=196 N=147 N=291 Dip. 6 Dip. 5 Dip. 9 Dip. 8 Dip. 2 Dip. 7 Dip. 4 Dip. 3 Dip. 1 Miss. 0.7% Miss. 2.7% Miss. 0.9% Miss. 1.1% Miss. 5.1% Miss. 2% Miss. 1.7% Risultato 21.8%, 9 dipartimenti, N=1455, 1.7% missing 21.8%

5c. Trattamento entro 60 giorni dalla mammografia di screening 9 51.7 46.6 44.9 56.2 50 49.4 48.8 44.8 43 42.5 39.7 37 35.5 28.2 27.7 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=540 N=592 N=571 N=833 N=841 N=823 N=841 N=865 N=1071 N=1131 N=1334 N=1282 N=1417 N=1463 N=1449 N=15053 Trend temporale 2001 2015

5c. Trattamento entro 60 giorni dalla mammografia di screening 71% 45.3% 38.2% 34.9% 30.6% 26.5% 21.3% 13.8% 7.7% N=71 N=151 N=147 N=196 N=124 N=114 N=261 N=94 N=291 Dip. 5 Dip. 6 Dip. 3 Dip. 4 Dip. 9 Dip. 2 Dip. 7 Dip. 8 Dip. 1 Miss. 2.8% Miss. 0.7% Miss. 2% Miss. 5.1% Miss. 0.9% Miss. 1.1% Miss. 1.4% Risultato 27.7%, 9 dipartimenti, N=1449, 1.7% missing 27.7%

6a. Unico intervento chirurgico per il trattamento del carcinoma invasivo 9 88.9 89.8 90.5 87.5 90 90.4 89.5 91.5 91.3 95.4 93.9 94 90.4 94 94.9 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=434 N=412 N=495 N=649 N=733 N=727 N=839 N=835 N=993 N=918 N=1060 N=1067 N=1123 N=1134 N=1138 N=12557 Trend temporale 2001 2015

6a. Unico intervento chirurgico per il trattamento del carcinoma invasivo 98.2% 98.1% 97.7% 95.8% 93.2% 93% 92.3% 90.9% 90.6% N=222 N=159 N=88 N=95 N=74 N=114 N=189 N=132 N=65 Dip. 1 Dip. 4 Dip. 2 Dip. 9 Dip. 8 Dip. 6 Dip. 7 Dip. 3 Dip. 5 Miss. 3.2% Miss. 1.5% Risultato 94.9%, 9 dipartimenti, N=1138, 0.6% missing 94.9%

6b. Unico intervento chirurgico per il trattamento del carcinoma non invasivo 9 88.2 89.1 89.4 82 81 88 89 89.8 89.1 88.5 88.1 86 91.4 91.6 87.8 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=85 N=128 N=94 N=122 N=116 N=125 N=136 N=157 N=176 N=156 N=182 N=168 N=198 N=202 N=173 N=2218 Trend temporale 2001 2015

6b. Unico intervento chirurgico per il trattamento del carcinoma non invasivo 100% 97.5% 88.2% 88.2% 88.2% 83.3% 82.9% 77.8% 77.8% N=7 N=40 N=17 N=17 N=17 N=12 N=36 N=18 N=9 Dip. 8 Dip. 1 Dip. 2 Dip. 3 Dip. 6 Dip. 9 Dip. 7 Dip. 4 Dip. 5 Miss. 2.8% Risultato 87.8%, 9 dipartimenti, N=173, 0.6% missing 87.8%

7. Almeno 10 linfonodi asportati nella dissezione ascellare (escluso sampling) 9 87.4 84.4 81.8 79.6 77.6 74.1 80.9 88.8 83.7 77.6 75.4 72.1 65.3 80.6 80.4 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=253 N=187 N=234 N=323 N=354 N=280 N=302 N=301 N=366 N=380 N=368 N=329 N=264 N=262 N=248 N=4451 Trend temporale 2001 2015

7. Almeno 10 linfonodi asportati nella dissezione ascellare (escluso sampling) 100% 93.1% 92.9% 91.3% 83.3% 80% 76.9% 75.6% 41.9% N=15 N=29 N=42 N=23 N=17 N=36 N=14 N=41 N=31 Dip. 8 Dip. 4 Dip. 3 Dip. 6 Dip. 2 Dip. 1 Dip. 5 Dip. 7 Dip. 9 Miss. 6.7% Miss. 29.4% Miss. 16.7% Miss. 7.1% Risultato 80.4%, 9 dipartimenti, N=248, 5.2% missing 80.4%

8. Esame solo del linfonodo/i sentinella nei casi che poi risulteranno pn0 9 47.7 64.1 64 62.8 90.2 91 87.8 87.8 84.2 82.9 78.7 76.9 70.4 93.9 92.8 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=239 N=262 N=303 N=398 N=443 N=450 N=480 N=493 N=605 N=588 N=620 N=611 N=656 N=672 N=670 N=7490 Trend temporale 2001 2015

8. Esame solo del linfonodo/i sentinella nei casi che poi risulteranno pn0 100% 98.9% 98% 97.7% 93.2% 93.2% 83.5% 77.9% N=51 N=92 N=54 N=132 N=75 N=74 N=124 N=68 Dip. 8 Dip. 4 Dip. 2 Dip. 1 Dip. 3 Dip. 6 Dip. 7 Dip. 9 Miss. 9.3% Miss. 1.3% Miss. 1.4% Miss. 21.8% Risultato 92.8%, 8 dipartimenti, N=670, 5.1% missing 92.8%

9. No dissezione ascellare (di qualsiasi livello, sampling incluso) nei carcinomi non invasivi 8 97.6 93.6 94.8 92.2 89.8 85.7 96.1 96.6 87.8 82 94.9 96.1 95.1 97.3 95.7 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=78 N=127 N=95 N=121 N=109 N=118 N=131 N=149 N=166 N=152 N=158 N=158 N=155 N=194 N=145 N=2056 Trend temporale 2001 2015

9. No dissezione ascellare (di qualsiasi livello, sampling incluso) nei carcinomi non invasivi 100% 100% 100% 100% 94.1% 91.2% 83.3% N=18 N=17 N=7 N=38 N=17 N=36 N=12 Dip. 4 Dip. 6 Dip. 8 Dip. 1 Dip. 3 Dip. 7 Dip. 9 Miss. 10.5% Miss. 5.6% Risultato 95.7%, 7 dipartimenti, N=145, 4.1% missing 95.7%

10. Asportazione di max 3 linfonodi nell'esame dell'ascella con linfonodo sentinella 5 94.1 91.2 94.2 95.8 97 94.8 96.1 92.2 95.9 96.6 95.3 96.2 95.9 97.1 97.1 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=208 N=295 N=339 N=504 N=596 N=661 N=651 N=644 N=870 N=891 N=969 N=1020 N=1052 N=1050 N=1057 N=10807 Trend temporale 2001 2015

10. Asportazione di max 3 linfonodi nell'esame dell'ascella con linfonodo sentinella 100% 100% 98.9% 98.6% 98.3% 98.2% 98.1% 93.1% 91.2% N=67 N=91 N=184 N=144 N=125 N=117 N=58 N=178 N=93 Dip. 8 Dip. 2 Dip. 1 Dip. 4 Dip. 3 Dip. 6 Dip. 5 Dip. 7 Dip. 9 Miss. 19.8% Miss. 2.7% Miss. 4.2% Miss. 4% Miss. 2.6% Miss. 8.6% Miss. 2.8% Miss. 2.2% Risultato 97.1%, 9 dipartimenti, N=1057, 4.6% missing 97.1%

11. Int. conservativo in carcinomi invasivi fino a 3 cm (inclusa componente non invasiva) 9 84.3 88.4 87.2 87.1 86.8 88.2 86.7 86.3 84.9 86.4 85 85.2 85.2 83.1 86 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=400 N=378 N=455 N=549 N=652 N=674 N=793 N=749 N=904 N=853 N=965 N=967 N=1006 N=921 N=1049 N=11315 Trend temporale 2001 2015

11. Int. conservativo in carcinomi invasivi fino a 3 cm (inclusa componente non invasiva) 95.4% 88.3% 87.4% 87.4% 84.4% 83.9% 81% 80.3% 79.4% N=109 N=164 N=95 N=208 N=149 N=78 N=63 N=118 N=65 Dip. 6 Dip. 7 Dip. 9 Dip. 1 Dip. 4 Dip. 2 Dip. 5 Dip. 3 Dip. 8 Miss. 11.6% Miss. 4.3% Miss. 1.3% Miss. 20.5% Miss. 7.9% Miss. 0.8% Miss. 3.1% Risultato 86%, 9 dipartimenti, N=1049, 5.1% missing 86%

12. Intervento conservativo in carcinomi in situ fino a 2 cm 9 95.7 98.2 96.2 84.6 84.8 96.9 94 92.6 92.9 92.9 89 88.8 90 86.4 100 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 N=46 N=57 N=53 N=52 N=46 N=68 N=64 N=83 N=83 N=80 N=95 N=88 N=99 N=100 N=99 N=1113 Trend temporale 2001 2015

12. Intervento conservativo in carcinomi in situ fino a 2 cm 100% 100% 100% 100% 94.4% 92.6% 80% 50% 0% N=14 N=13 N=8 N=8 N=19 N=27 N=5 N=4 N=1 Dip. 6 Dip. 3 Dip. 2 Dip. 4 Dip. 7 Dip. 1 Dip. 9 Dip. 8 Dip. 5 Miss. 5.3% Risultato 92.9%, 9 dipartimenti, N=99, 1% missing 92.9%

Indicatori di diagnosi e terapia 12 92.9% 1 87.6% 2a 75.2% 11 86% 2b 93.2% 10 97.1% 9 95.7% 8 92.8% 4 84.6% 5a 33.4% 5b 21.8% 7 80.4% 6b 87.8% 6a 94.9% 5c 27.7%